STRINGSTRING
hpt hpt folB folB purU-3 purU-3 folD-3 folD-3 CEW89_13060 CEW89_13060 CEW89_13030 CEW89_13030 dnaQ dnaQ coaE coaE aroE aroE CEW89_12920 CEW89_12920 rho rho CEW89_12885 CEW89_12885 hemH hemH nusA nusA CEW89_12645 CEW89_12645 CEW89_12565 CEW89_12565 nrdF nrdF rfbC rfbC rfbD rfbD queG queG CEW89_12465 CEW89_12465 dxs dxs amn amn aroC aroC CEW89_13475 CEW89_13475 pncB pncB CEW89_13450 CEW89_13450 CEW89_13325 CEW89_13325 acs-2 acs-2 CEW89_10270 CEW89_10270 CEW89_10545 CEW89_10545 ackA ackA hemN hemN hemC hemC hemE hemE CEW89_10645 CEW89_10645 CEW89_10705 CEW89_10705 dnaX dnaX accA accA CEW89_11085 CEW89_11085 pyrB pyrB CEW89_11135 CEW89_11135 CEW89_11425 CEW89_11425 fcl fcl GCA_001550095_03605 GCA_001550095_03605 GCA_001550095_03597 GCA_001550095_03597 GCA_001550095_03583 GCA_001550095_03583 GCA_001550095_03548 GCA_001550095_03548 GCA_001550095_03547 GCA_001550095_03547 GCA_001550095_03542 GCA_001550095_03542 ctaB-2 ctaB-2 accC accC hydA hydA acs acs CEW89_09760 CEW89_09760 dut dut CEW89_09875 CEW89_09875 CEW89_09885 CEW89_09885 CEW89_09890 CEW89_09890 CEW89_06310 CEW89_06310 pdhA pdhA purC purC purS purS purQ purQ CEW89_05995 CEW89_05995 CEW89_05990 CEW89_05990 GCA_001550095_03150 GCA_001550095_03150 carB carB tdk tdk purE purE purK purK murA murA CEW89_17975 CEW89_17975 pabB pabB mtnP mtnP apt apt ctaB ctaB CEW89_03445 CEW89_03445 gmk gmk CEW89_03645 CEW89_03645 CEW89_03690 CEW89_03690 CEW89_03730 CEW89_03730 pyrH pyrH aroB aroB aroK aroK hemA hemA CEW89_04660 CEW89_04660 CEW89_04460 CEW89_04460 CEW89_04380 CEW89_04380 CEW89_04360 CEW89_04360 CEW89_04350 CEW89_04350 thiG thiG thiS thiS thiC thiC nadA nadA CEW89_04315 CEW89_04315 CEW89_04310 CEW89_04310 serS serS CEW89_06620 CEW89_06620 GCA_001550095_02556 GCA_001550095_02556 CEW89_18975 CEW89_18975 CEW89_18920 CEW89_18920 pyrD-2 pyrD-2 upp upp CEW89_18460 CEW89_18460 prpE prpE CEW89_18415 CEW89_18415 CEW89_15990 CEW89_15990 bluB bluB atpB-2 atpB-2 atpE-2 atpE-2 atpF-3 atpF-3 atpF-2 atpF-2 polA polA CEW89_16330 CEW89_16330 nadE nadE purM purM purN purN CEW89_03185 CEW89_03185 cobB cobB cobA cobA cbiD cbiD CEW89_03320 CEW89_03320 pdxJ pdxJ rpoZ rpoZ folK folK cobM cobM cobJ cobJ cobI cobI CEW89_14700 CEW89_14700 CEW89_14695 CEW89_14695 CEW89_14690 CEW89_14690 CEW89_14665 CEW89_14665 cobD cobD CEW89_14640 CEW89_14640 cobW cobW CEW89_14630 CEW89_14630 cobO cobO CEW89_14475 CEW89_14475 CEW89_14430 CEW89_14430 accD accD CEW89_14380 CEW89_14380 CEW89_14190 CEW89_14190 atpA-2 atpA-2 atpF atpF atpE atpE atpB atpB atpC-2 atpC-2 atpD-2 atpD-2 CEW89_14090 CEW89_14090 GCA_001550095_01862 GCA_001550095_01862 CEW89_13620 CEW89_13620 CEW89_13595 CEW89_13595 CEW89_14925 CEW89_14925 nusG nusG rpoB rpoB rpoC rpoC ndk ndk CEW89_02835 CEW89_02835 pdxA pdxA CEW89_01755 CEW89_01755 ctaA ctaA CEW89_01710 CEW89_01710 tgt tgt GCA_001550095_01554 GCA_001550095_01554 rpoA rpoA adk adk CEW89_15195 CEW89_15195 GCA_001550095_01407 GCA_001550095_01407 CEW89_08205 CEW89_08205 cobQ cobQ CEW89_16670 CEW89_16670 nadD nadD CEW89_08835 CEW89_08835 trpE trpE gpt gpt pdxH pdxH queF queF aroA aroA cmk cmk trpF trpF trpB trpB CEW89_16940 CEW89_16940 trpA trpA CEW89_16990 CEW89_16990 CEW89_17010 CEW89_17010 CEW89_17015 CEW89_17015 folD-2 folD-2 purU-2 purU-2 priA priA aroQ aroQ CEW89_17525 CEW89_17525 folD folD CEW89_05920 CEW89_05920 CEW89_05930 CEW89_05930 CEW89_19105 CEW89_19105 CEW89_19215 CEW89_19215 CEW89_19365 CEW89_19365 dnaG dnaG rpoD rpoD nusB nusB rpoH rpoH cobS-2 cobS-2 cobT-2 cobT-2 cobT cobT CEW89_00225 CEW89_00225 carA carA CEW89_00475 CEW89_00475 tmk tmk CEW89_01630 CEW89_01630 GCA_001550095_00680 GCA_001550095_00680 GCA_001550095_00665 GCA_001550095_00665 CEW89_09310 CEW89_09310 atpH atpH atpA atpA atpG atpG atpD atpD atpC atpC prs prs ribF ribF CEW89_04980 CEW89_04980 CEW89_05090 CEW89_05090 guaA guaA guaB guaB CEW89_05440 CEW89_05440 CEW89_05535 CEW89_05535 pyrD pyrD pyrE-2 pyrE-2 CEW89_05570 CEW89_05570 CEW89_12255 CEW89_12255 CEW89_12090 CEW89_12090 purH purH dinB dinB pyrF pyrF thyA thyA CEW89_08125 CEW89_08125 pyrG pyrG purA purA GCA_001550095_00235 GCA_001550095_00235 purU purU purD purD folE2 folE2 folP folP glmU glmU coaX coaX purF purF CEW89_07290 CEW89_07290 pyrE pyrE pyrC pyrC CEW89_07150 CEW89_07150 coaD coaD CEW89_07020 CEW89_07020 purL purL trpC trpC trpD trpD queA queA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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hptUnannotated protein; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (185 aa)
folBUnannotated protein; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (120 aa)
purU-3Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (285 aa)
folD-3Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
CEW89_13060Unannotated protein; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (227 aa)
CEW89_13030Unannotated protein. (196 aa)
dnaQUnannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (246 aa)
coaEUnannotated protein; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (199 aa)
aroEUnannotated protein; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (276 aa)
CEW89_12920Unannotated protein. (150 aa)
rhoUnannotated protein; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (423 aa)
CEW89_12885Unannotated protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (385 aa)
hemHUnannotated protein; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (361 aa)
nusAUnannotated protein; Participates in both transcription termination and antitermination. (536 aa)
CEW89_12645Unannotated protein. (266 aa)
CEW89_12565Unannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (707 aa)
nrdFUnannotated protein; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (323 aa)
rfbCUnannotated protein; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (186 aa)
rfbDUnannotated protein; Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose; Belongs to the dTDP-4-dehydrorhamnose reductase family. (283 aa)
queGUnannotated protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (346 aa)
CEW89_12465Unannotated protein; Belongs to the FPP/GGPP synthase family. (288 aa)
dxsUnannotated protein; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (642 aa)
amnUnannotated protein; Catalyzes the hydrolysis of the N-glycosidic bond of AMP to form adenine and ribose 5-phosphate. Involved in regulation of AMP concentrations. (494 aa)
aroCUnannotated protein; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (366 aa)
CEW89_13475Unannotated protein; Involved in the import of queuosine (Q) precursors, required for Q precursor salvage; Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily. (213 aa)
pncBUnannotated protein; Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP; Belongs to the NAPRTase family. (430 aa)
CEW89_13450Unannotated protein. (203 aa)
CEW89_13325Unannotated protein; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication [...] (372 aa)
acs-2Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (617 aa)
CEW89_10270Unannotated protein. (701 aa)
CEW89_10545Unannotated protein. (461 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (387 aa)
hemNUnannotated protein; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (451 aa)
hemCUnannotated protein; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (314 aa)
hemEUnannotated protein; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (344 aa)
CEW89_10645Unannotated protein. (297 aa)
CEW89_10705Unannotated protein. (276 aa)
dnaXUnannotated protein; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (592 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa)
CEW89_11085Unannotated protein; Belongs to the UPF0301 (AlgH) family. (189 aa)
pyrBUnannotated protein; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (319 aa)
CEW89_11135Unannotated protein. (421 aa)
CEW89_11425Unannotated protein. (145 aa)
fclUnannotated protein; Catalyzes the two-step NADP-dependent conversion of GDP-4- dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. (326 aa)
GCA_001550095_03605Unannotated protein. (624 aa)
GCA_001550095_03597Unannotated protein. (85 aa)
GCA_001550095_03583Unannotated protein. (389 aa)
GCA_001550095_03548Unannotated protein. (386 aa)
GCA_001550095_03547Unannotated protein. (203 aa)
GCA_001550095_03542Unannotated protein. (497 aa)
ctaB-2Unannotated protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. (318 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
hydAUnannotated protein. (483 aa)
acsUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (617 aa)
CEW89_09760Unannotated protein. (1151 aa)
dutUnannotated protein; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (155 aa)
CEW89_09875Unannotated protein; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (399 aa)
CEW89_09885Unannotated protein; Belongs to the sigma-70 factor family. (293 aa)
CEW89_09890Unannotated protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (182 aa)
CEW89_06310Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (455 aa)
pdhAUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (341 aa)
purCUnannotated protein; Belongs to the SAICAR synthetase family. (255 aa)
purSUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (76 aa)
purQUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (222 aa)
CEW89_05995Unannotated protein. (433 aa)
CEW89_05990Unannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (435 aa)
GCA_001550095_03150Unannotated protein. (236 aa)
carBUnannotated protein; Belongs to the CarB family. (1129 aa)
tdkUnannotated protein. (193 aa)
purEUnannotated protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (161 aa)
purKUnannotated protein; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (363 aa)
murAUnannotated protein; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (422 aa)
CEW89_17975Unannotated protein. (137 aa)
pabBUnannotated protein. (372 aa)
mtnPUnannotated protein; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (293 aa)
aptUnannotated protein; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (176 aa)
ctaBUnannotated protein; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group; Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily. (316 aa)
CEW89_03445Unannotated protein; Belongs to the ALAD family. (332 aa)
gmkUnannotated protein; Essential for recycling GMP and indirectly, cGMP. (219 aa)
CEW89_03645Unannotated protein. (456 aa)
CEW89_03690Unannotated protein. (195 aa)
CEW89_03730Unannotated protein. (95 aa)
pyrHUnannotated protein; Catalyzes the reversible phosphorylation of UMP to UDP. (253 aa)
aroBUnannotated protein; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (369 aa)
aroKUnannotated protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (181 aa)
hemAUnannotated protein. (409 aa)
CEW89_04660Unannotated protein. (330 aa)
CEW89_04460Unannotated protein. (254 aa)
CEW89_04380Unannotated protein. (145 aa)
CEW89_04360Unannotated protein. (248 aa)
CEW89_04350Unannotated protein; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). (202 aa)
thiGUnannotated protein; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (253 aa)
thiSUnannotated protein. (65 aa)
thiCUnannotated protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (595 aa)
nadAUnannotated protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (322 aa)
CEW89_04315Unannotated protein; Catalyzes the oxidation of L-aspartate to iminoaspartate. (530 aa)
CEW89_04310Unannotated protein; Belongs to the NadC/ModD family. (296 aa)
serSUnannotated protein; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa)
CEW89_06620Unannotated protein; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (434 aa)
GCA_001550095_02556Unannotated protein. (382 aa)
CEW89_18975Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa)
CEW89_18920Unannotated protein. (158 aa)
pyrD-2Unannotated protein; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (357 aa)
uppUnannotated protein; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (210 aa)
CEW89_18460Unannotated protein. (330 aa)
prpEUnannotated protein. (630 aa)
CEW89_18415Unannotated protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (252 aa)
CEW89_15990Unannotated protein. (317 aa)
bluBUnannotated protein. (215 aa)
atpB-2Unannotated protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (258 aa)
atpE-2Unannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (78 aa)
atpF-3Unannotated protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (181 aa)
atpF-2Unannotated protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (190 aa)
polAUnannotated protein; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (934 aa)
CEW89_16330Unannotated protein. (343 aa)
nadEUnannotated protein; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (555 aa)
purMUnannotated protein. (348 aa)
purNUnannotated protein; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (197 aa)
CEW89_03185Unannotated protein. (141 aa)
cobBUnannotated protein; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (422 aa)
cobAUnannotated protein; Belongs to the precorrin methyltransferase family. (286 aa)
cbiDUnannotated protein; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (320 aa)
CEW89_03320Unannotated protein. (245 aa)
pdxJUnannotated protein; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (248 aa)
rpoZUnannotated protein; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (117 aa)
folKUnannotated protein. (202 aa)
cobMUnannotated protein. (255 aa)
cobJUnannotated protein. (606 aa)
cobIUnannotated protein; Belongs to the precorrin methyltransferase family. (238 aa)
CEW89_14700Unannotated protein. (398 aa)
CEW89_14695Unannotated protein. (212 aa)
CEW89_14690Unannotated protein. (429 aa)
CEW89_14665Unannotated protein. (319 aa)
cobDUnannotated protein; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (300 aa)
CEW89_14640Unannotated protein. (224 aa)
cobWUnannotated protein. (355 aa)
CEW89_14630Unannotated protein. (1225 aa)
cobOUnannotated protein; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (204 aa)
CEW89_14475Unannotated protein. (100 aa)
CEW89_14430Unannotated protein. (245 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (321 aa)
CEW89_14380Unannotated protein; Belongs to the folylpolyglutamate synthase family. (424 aa)
CEW89_14190Unannotated protein. (279 aa)
atpA-2Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (504 aa)
atpFUnannotated protein; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (244 aa)
atpEUnannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (82 aa)
atpBUnannotated protein; Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (230 aa)
atpC-2Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (151 aa)
atpD-2Unannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (477 aa)
CEW89_14090Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (202 aa)
GCA_001550095_01862Unannotated protein. (296 aa)
CEW89_13620Unannotated protein. (141 aa)
CEW89_13595Unannotated protein. (401 aa)
CEW89_14925Unannotated protein; Belongs to the Cob(I)alamin adenosyltransferase family. (192 aa)
nusGUnannotated protein; Participates in transcription elongation, termination and antitermination. (177 aa)
rpoBUnannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1378 aa)
rpoCUnannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1415 aa)
ndkUnannotated protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
CEW89_02835Unannotated protein. (152 aa)
pdxAUnannotated protein; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (334 aa)
CEW89_01755Unannotated protein. (392 aa)
ctaAUnannotated protein; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (380 aa)
CEW89_01710Unannotated protein. (208 aa)
tgtUnannotated protein; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. [...] (381 aa)
GCA_001550095_01554Unannotated protein. (203 aa)
rpoAUnannotated protein; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (338 aa)
adkUnannotated protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (191 aa)
CEW89_15195Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (169 aa)
GCA_001550095_01407Unannotated protein. (288 aa)
CEW89_08205Unannotated protein. (279 aa)
cobQUnannotated protein; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (483 aa)
CEW89_16670Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (193 aa)
nadDUnannotated protein; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (209 aa)
CEW89_08835Unannotated protein. (133 aa)
trpEUnannotated protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (504 aa)
gptUnannotated protein; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. (167 aa)
pdxHUnannotated protein; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (205 aa)
queFUnannotated protein; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (154 aa)
aroAUnannotated protein; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (449 aa)
cmkUnannotated protein. (202 aa)
trpFUnannotated protein; Belongs to the TrpF family. (213 aa)
trpBUnannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (416 aa)
CEW89_16940Unannotated protein. (554 aa)
trpAUnannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa)
CEW89_16990Unannotated protein. (322 aa)
CEW89_17010Unannotated protein. (388 aa)
CEW89_17015Unannotated protein. (336 aa)
folD-2Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (305 aa)
purU-2Unannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
priAUnannotated protein; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (755 aa)
aroQUnannotated protein; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (145 aa)
CEW89_17525Unannotated protein. (105 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa)
CEW89_05920Unannotated protein. (265 aa)
CEW89_05930Unannotated protein. (733 aa)
CEW89_19105Unannotated protein; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (188 aa)
CEW89_19215Unannotated protein. (411 aa)
CEW89_19365Unannotated protein; Belongs to the sigma-70 factor family. ECF subfamily. (209 aa)
dnaGUnannotated protein; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (701 aa)
rpoDUnannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (665 aa)
nusBUnannotated protein; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (161 aa)
rpoHUnannotated protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (298 aa)
cobS-2Unannotated protein; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (250 aa)
cobT-2Unannotated protein; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (334 aa)
cobTUnannotated protein. (624 aa)
CEW89_00225Unannotated protein; Belongs to the BolA/IbaG family. (85 aa)
carAUnannotated protein; Belongs to the CarA family. (389 aa)
CEW89_00475Unannotated protein. (386 aa)
tmkUnannotated protein; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (203 aa)
CEW89_01630Unannotated protein. (497 aa)
GCA_001550095_00680Unannotated protein. (403 aa)
GCA_001550095_00665Unannotated protein. (675 aa)
CEW89_09310Unannotated protein. (315 aa)
atpHUnannotated protein; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (186 aa)
atpAUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (512 aa)
atpGUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (290 aa)
atpDUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (476 aa)
atpCUnannotated protein; Produces ATP from ADP in the presence of a proton gradient across the membrane. (135 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (338 aa)
ribFUnannotated protein; Belongs to the ribF family. (308 aa)
CEW89_04980Unannotated protein. (400 aa)
CEW89_05090Unannotated protein; Belongs to the CinA family. (166 aa)
guaAUnannotated protein; Catalyzes the synthesis of GMP from XMP. (523 aa)
guaBUnannotated protein; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (483 aa)
CEW89_05440Unannotated protein. (356 aa)
CEW89_05535Unannotated protein. (279 aa)
pyrDUnannotated protein; Catalyzes the conversion of dihydroorotate to orotate. (312 aa)
pyrE-2Unannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (240 aa)
CEW89_05570Unannotated protein. (348 aa)
CEW89_12255Unannotated protein. (188 aa)
CEW89_12090Unannotated protein. (209 aa)
purHUnannotated protein. (529 aa)
dinBUnannotated protein; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (422 aa)
pyrFUnannotated protein; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa)
thyAUnannotated protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
CEW89_08125Unannotated protein; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (157 aa)
pyrGUnannotated protein; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (547 aa)
purAUnannotated protein; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (431 aa)
GCA_001550095_00235Unannotated protein. (246 aa)
purUUnannotated protein; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (294 aa)
purDUnannotated protein; Belongs to the GARS family. (421 aa)
folE2Unannotated protein; Converts GTP to 7,8-dihydroneopterin triphosphate. (367 aa)
folPUnannotated protein. (342 aa)
glmUUnannotated protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (450 aa)
coaXUnannotated protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (258 aa)
purFUnannotated protein; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (490 aa)
CEW89_07290Unannotated protein; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (510 aa)
pyrEUnannotated protein; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (226 aa)
pyrCUnannotated protein; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (346 aa)
CEW89_07150Unannotated protein. (170 aa)
coaDUnannotated protein; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (164 aa)
CEW89_07020Unannotated protein; Belongs to the BolA/IbaG family. (76 aa)
purLUnannotated protein; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the amm [...] (719 aa)
trpCUnannotated protein; Belongs to the TrpC family. (266 aa)
trpDUnannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa)
queAUnannotated protein; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (353 aa)
Your Current Organism:
Celeribacter ethanolicus
NCBI taxonomy Id: 1758178
Other names: C. ethanolicus, CGMCC 1.15406, Celeribacter ethanolicus Jian et al. 2016, Celeribacter sp. NH195, JCM 31095, strain NH195
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