STRINGSTRING
CEW89_15650 CEW89_15650 trpD trpD trpC trpC argC argC alr alr ilvC ilvC CEW89_11615 CEW89_11615 dapB dapB CEW89_05450 CEW89_05450 metAA metAA CEW89_09310 CEW89_09310 carA carA CEW89_19430 CEW89_19430 CEW89_19305 CEW89_19305 folD folD folD-2 folD-2 CEW89_17260 CEW89_17260 CEW89_17255 CEW89_17255 trpA trpA trpB trpB trpF trpF CEW89_01310 CEW89_01310 trpE trpE CEW89_01175 CEW89_01175 CEW89_08790 CEW89_08790 metF metF argB argB proB proB proA proA CEW89_13530 CEW89_13530 CEW89_13535 CEW89_13535 serB serB dapD dapD dapE dapE leuC leuC leuD leuD leuB leuB ilvD ilvD asd asd dapA dapA CEW89_03140 CEW89_03140 leuA leuA CEW89_15990 CEW89_15990 glyA glyA CEW89_18610 CEW89_18610 GCA_001550095_02550 GCA_001550095_02550 GCA_001550095_02602 GCA_001550095_02602 CEW89_06685 CEW89_06685 serS serS CEW89_04745 CEW89_04745 CEW89_03730 CEW89_03730 CEW89_03425 CEW89_03425 CEW89_03415 CEW89_03415 GCA_001550095_02991 GCA_001550095_02991 CEW89_15610 CEW89_15610 CEW89_15555 CEW89_15555 CEW89_17695 CEW89_17695 mtnP mtnP pabB pabB CEW89_17775 CEW89_17775 proC proC carB carB CEW89_18175 CEW89_18175 argD argD argF argF CEW89_06050 CEW89_06050 cysE cysE CEW89_00990 CEW89_00990 GCA_001550095_03583 GCA_001550095_03583 dmpG dmpG argH argH lysA lysA CEW89_10705 CEW89_10705 dapF dapF ilvE ilvE CEW89_12515 CEW89_12515 CEW89_12520 CEW89_12520 argJ argJ argG argG folD-3 folD-3 glyA-2 glyA-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CEW89_15650Unannotated protein. (113 aa)
trpDUnannotated protein; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (338 aa)
trpCUnannotated protein; Belongs to the TrpC family. (266 aa)
argCUnannotated protein; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (342 aa)
alrUnannotated protein; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (346 aa)
ilvCUnannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (340 aa)
CEW89_11615Unannotated protein; Belongs to the glutamate synthase family. (510 aa)
dapBUnannotated protein; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (269 aa)
CEW89_05450Unannotated protein; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1135 aa)
metAAUnannotated protein; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine; Belongs to the MetA family. (307 aa)
CEW89_09310Unannotated protein. (315 aa)
carAUnannotated protein; Belongs to the CarA family. (389 aa)
CEW89_19430Unannotated protein. (436 aa)
CEW89_19305Unannotated protein. (290 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa)
folD-2Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (305 aa)
CEW89_17260Unannotated protein; Belongs to the glutamate synthase family. (441 aa)
CEW89_17255Unannotated protein. (228 aa)
trpAUnannotated protein; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (263 aa)
trpBUnannotated protein; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (416 aa)
trpFUnannotated protein; Belongs to the TrpF family. (213 aa)
CEW89_01310Unannotated protein. (188 aa)
trpEUnannotated protein; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia. (504 aa)
CEW89_01175Unannotated protein. (555 aa)
CEW89_08790Unannotated protein; Belongs to the UbiA prenyltransferase family. (478 aa)
metFUnannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (277 aa)
argBUnannotated protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (296 aa)
proBUnannotated protein; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa)
proAUnannotated protein; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (421 aa)
CEW89_13530Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa)
CEW89_13535Unannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (380 aa)
serBUnannotated protein. (292 aa)
dapDUnannotated protein; Belongs to the transferase hexapeptide repeat family. (275 aa)
dapEUnannotated protein; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (381 aa)
leuCUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (475 aa)
leuDUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (201 aa)
leuBUnannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (367 aa)
ilvDUnannotated protein; Belongs to the IlvD/Edd family. (614 aa)
asdUnannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa)
dapAUnannotated protein; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (290 aa)
CEW89_03140Unannotated protein; Belongs to the alpha-IPM synthase/homocitrate synthase family. (542 aa)
leuAUnannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (525 aa)
CEW89_15990Unannotated protein. (317 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
CEW89_18610Unannotated protein. (367 aa)
GCA_001550095_02550Unannotated protein. (342 aa)
GCA_001550095_02602Unannotated protein. (667 aa)
CEW89_06685Unannotated protein. (425 aa)
serSUnannotated protein; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (430 aa)
CEW89_04745Unannotated protein. (237 aa)
CEW89_03730Unannotated protein. (95 aa)
CEW89_03425Unannotated protein. (329 aa)
CEW89_03415Unannotated protein. (678 aa)
GCA_001550095_02991Unannotated protein. (189 aa)
CEW89_15610Unannotated protein. (466 aa)
CEW89_15555Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (347 aa)
CEW89_17695Unannotated protein. (460 aa)
mtnPUnannotated protein; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (293 aa)
pabBUnannotated protein. (372 aa)
CEW89_17775Unannotated protein; Belongs to the aspartokinase family. (411 aa)
proCUnannotated protein; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (268 aa)
carBUnannotated protein; Belongs to the CarB family. (1129 aa)
CEW89_18175Unannotated protein. (233 aa)
argDUnannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (388 aa)
argFUnannotated protein; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (309 aa)
CEW89_06050Unannotated protein. (348 aa)
cysEUnannotated protein. (273 aa)
CEW89_00990Unannotated protein. (445 aa)
GCA_001550095_03583Unannotated protein. (389 aa)
dmpGUnannotated protein; Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta- cleavage pathway for the degradation of aromatic compounds. Belongs to the 4-hydroxy-2-oxovalerate aldolase family. (339 aa)
argHUnannotated protein. (463 aa)
lysAUnannotated protein; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (421 aa)
CEW89_10705Unannotated protein. (276 aa)
dapFUnannotated protein; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (278 aa)
ilvEUnannotated protein; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (289 aa)
CEW89_12515Unannotated protein. (1511 aa)
CEW89_12520Unannotated protein. (477 aa)
argJUnannotated protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (415 aa)
argGUnannotated protein; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (407 aa)
folD-3Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
glyA-2Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
Your Current Organism:
Celeribacter ethanolicus
NCBI taxonomy Id: 1758178
Other names: C. ethanolicus, CGMCC 1.15406, Celeribacter ethanolicus Jian et al. 2016, Celeribacter sp. NH195, JCM 31095, strain NH195
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