STRINGSTRING
lpdA lpdA CEW89_06920 CEW89_06920 tkt tkt gap gap gap-2 gap-2 mmsA mmsA CEW89_07165 CEW89_07165 glcB glcB CEW89_07755 CEW89_07755 rpiA rpiA rpiB rpiB CEW89_05640 CEW89_05640 CEW89_05630 CEW89_05630 CEW89_05380 CEW89_05380 CEW89_05250 CEW89_05250 CEW89_09200 CEW89_09200 prs prs glpX glpX CEW89_19225 CEW89_19225 CEW89_19210 CEW89_19210 CEW89_19180 CEW89_19180 CEW89_05925 CEW89_05925 lpdA-2 lpdA-2 folD folD fsa fsa CEW89_17315 CEW89_17315 folD-2 folD-2 CEW89_17230 CEW89_17230 CEW89_17225 CEW89_17225 CEW89_17215 CEW89_17215 CEW89_17210 CEW89_17210 CEW89_17085 CEW89_17085 CEW89_16705 CEW89_16705 CEW89_01135 CEW89_01135 CEW89_08800 CEW89_08800 CEW89_05660 CEW89_05660 CEW89_08275 CEW89_08275 metF metF CEW89_01445 CEW89_01445 edd edd tpiA tpiA CEW89_01570 CEW89_01570 CEW89_13525 CEW89_13525 CEW89_13530 CEW89_13530 CEW89_13535 CEW89_13535 serB serB gpmI gpmI CEW89_14145 CEW89_14145 accD accD CEW89_14850 CEW89_14850 pckA pckA CEW89_14905 CEW89_14905 pgi pgi pgl pgl zwf zwf fumC fumC gcvP gcvP gcvH gcvH gcvT gcvT CEW89_16590 CEW89_16590 CEW89_16320 CEW89_16320 glyA glyA CEW89_18440 CEW89_18440 CEW89_18490 CEW89_18490 CEW89_18495 CEW89_18495 gap-3 gap-3 CEW89_18855 CEW89_18855 CEW89_06645 CEW89_06645 acnA acnA CEW89_03545 CEW89_03545 CEW89_15555 CEW89_15555 CEW89_15550 CEW89_15550 CEW89_18025 CEW89_18025 mce mce CEW89_18305 CEW89_18305 CEW89_06050 CEW89_06050 eno eno pgk pgk CEW89_06290 CEW89_06290 pdhA pdhA CEW89_06310 CEW89_06310 CEW89_06315 CEW89_06315 cysE cysE lpdA-3 lpdA-3 CEW89_10150 CEW89_10150 CEW89_10145 CEW89_10145 sucD sucD sucC sucC mdh mdh CEW89_10100 CEW89_10100 CEW89_10085 CEW89_10085 sdhC sdhC sdhD sdhD CEW89_10070 CEW89_10070 CEW89_10065 CEW89_10065 CEW89_10030 CEW89_10030 ccrA ccrA acs acs accB accB accC accC nifJ nifJ CEW89_10995 CEW89_10995 CEW89_10990 CEW89_10990 accA accA CEW89_10920 CEW89_10920 pyk pyk ackA ackA CEW89_10430 CEW89_10430 CEW89_10425 CEW89_10425 acs-2 acs-2 CEW89_13310 CEW89_13310 fghA fghA ilvA ilvA CEW89_12850 CEW89_12850 folD-3 folD-3 fdhA fdhA CEW89_15805 CEW89_15805 glyA-2 glyA-2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lpdAUnannotated protein. (464 aa)
CEW89_06920Unannotated protein; Belongs to the citrate synthase family. (432 aa)
tktUnannotated protein; Belongs to the transketolase family. (673 aa)
gapUnannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (331 aa)
gap-2Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (333 aa)
mmsAUnannotated protein. (499 aa)
CEW89_07165Unannotated protein. (416 aa)
glcBUnannotated protein; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (713 aa)
CEW89_07755Unannotated protein. (848 aa)
rpiAUnannotated protein; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (261 aa)
rpiBUnannotated protein. (149 aa)
CEW89_05640Unannotated protein. (751 aa)
CEW89_05630Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
CEW89_05380Unannotated protein; Belongs to the bacterial glucokinase family. (324 aa)
CEW89_05250Unannotated protein; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (404 aa)
CEW89_09200Unannotated protein. (147 aa)
prsUnannotated protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (338 aa)
glpXUnannotated protein. (324 aa)
CEW89_19225Unannotated protein. (707 aa)
CEW89_19210Unannotated protein. (665 aa)
CEW89_19180Unannotated protein. (510 aa)
CEW89_05925Unannotated protein. (410 aa)
lpdA-2Unannotated protein. (466 aa)
folDUnannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (300 aa)
fsaUnannotated protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (217 aa)
CEW89_17315Unannotated protein; Belongs to the GcvT family. (377 aa)
folD-2Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (305 aa)
CEW89_17230Unannotated protein; Belongs to the GcvT family. (790 aa)
CEW89_17225Unannotated protein. (67 aa)
CEW89_17215Unannotated protein. (974 aa)
CEW89_17210Unannotated protein. (508 aa)
CEW89_17085Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
CEW89_16705Unannotated protein. (504 aa)
CEW89_01135Unannotated protein. (726 aa)
CEW89_08800Unannotated protein. (467 aa)
CEW89_05660Unannotated protein. (294 aa)
CEW89_08275Unannotated protein. (399 aa)
metFUnannotated protein; Belongs to the methylenetetrahydrofolate reductase family. (277 aa)
CEW89_01445Unannotated protein. (213 aa)
eddUnannotated protein; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (609 aa)
tpiAUnannotated protein; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
CEW89_01570Unannotated protein; Belongs to the pyruvate kinase family. (501 aa)
CEW89_13525Unannotated protein; Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. (376 aa)
CEW89_13530Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (530 aa)
CEW89_13535Unannotated protein; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (380 aa)
serBUnannotated protein. (292 aa)
gpmIUnannotated protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (508 aa)
CEW89_14145Unannotated protein; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (805 aa)
accDUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (321 aa)
CEW89_14850Unannotated protein. (557 aa)
pckAUnannotated protein; Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA. (532 aa)
CEW89_14905Unannotated protein. (291 aa)
pgiUnannotated protein; Belongs to the GPI family. (540 aa)
pglUnannotated protein; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (223 aa)
zwfUnannotated protein; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (484 aa)
fumCUnannotated protein; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
gcvPUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (948 aa)
gcvHUnannotated protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (123 aa)
gcvTUnannotated protein. (379 aa)
CEW89_16590Unannotated protein; Belongs to the carbohydrate kinase PfkB family. (317 aa)
CEW89_16320Unannotated protein; Belongs to the ribulose-phosphate 3-epimerase family. (232 aa)
glyAUnannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (431 aa)
CEW89_18440Unannotated protein. (760 aa)
CEW89_18490Unannotated protein. (735 aa)
CEW89_18495Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
gap-3Unannotated protein; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (344 aa)
CEW89_18855Unannotated protein. (728 aa)
CEW89_06645Unannotated protein. (929 aa)
acnAUnannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (915 aa)
CEW89_03545Unannotated protein; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (468 aa)
CEW89_15555Unannotated protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (347 aa)
CEW89_15550Unannotated protein. (162 aa)
CEW89_18025Unannotated protein. (338 aa)
mceUnannotated protein. (134 aa)
CEW89_18305Unannotated protein; Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH. (473 aa)
CEW89_06050Unannotated protein. (348 aa)
enoUnannotated protein; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa)
pgkUnannotated protein; Belongs to the phosphoglycerate kinase family. (395 aa)
CEW89_06290Unannotated protein. (297 aa)
pdhAUnannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (341 aa)
CEW89_06310Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (455 aa)
CEW89_06315Unannotated protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (435 aa)
cysEUnannotated protein. (273 aa)
lpdA-3Unannotated protein. (464 aa)
CEW89_10150Unannotated protein; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (501 aa)
CEW89_10145Unannotated protein. (986 aa)
sucDUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
sucCUnannotated protein; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (397 aa)
mdhUnannotated protein; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (320 aa)
CEW89_10100Unannotated protein; Belongs to the HpcH/HpaI aldolase family. (320 aa)
CEW89_10085Unannotated protein. (343 aa)
sdhCUnannotated protein. (129 aa)
sdhDUnannotated protein. (123 aa)
CEW89_10070Unannotated protein; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (602 aa)
CEW89_10065Unannotated protein; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (259 aa)
CEW89_10030Unannotated protein. (664 aa)
ccrAUnannotated protein. (426 aa)
acsUnannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (617 aa)
accBUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (162 aa)
accCUnannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa)
nifJUnannotated protein. (1211 aa)
CEW89_10995Unannotated protein. (240 aa)
CEW89_10990Unannotated protein; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
accAUnannotated protein; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (320 aa)
CEW89_10920Unannotated protein; Belongs to the HpcH/HpaI aldolase family. (319 aa)
pykUnannotated protein; Belongs to the pyruvate kinase family. (482 aa)
ackAUnannotated protein; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (387 aa)
CEW89_10430Unannotated protein. (458 aa)
CEW89_10425Unannotated protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (77 aa)
acs-2Unannotated protein; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (617 aa)
CEW89_13310Unannotated protein; Belongs to the enoyl-CoA hydratase/isomerase family. (258 aa)
fghAUnannotated protein; Serine hydrolase involved in the detoxification of formaldehyde. (279 aa)
ilvAUnannotated protein; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (416 aa)
CEW89_12850Unannotated protein. (754 aa)
folD-3Unannotated protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
fdhAUnannotated protein. (395 aa)
CEW89_15805Unannotated protein; Belongs to the iron-sulfur dependent L-serine dehydratase family. (468 aa)
glyA-2Unannotated protein; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (422 aa)
Your Current Organism:
Celeribacter ethanolicus
NCBI taxonomy Id: 1758178
Other names: C. ethanolicus, CGMCC 1.15406, Celeribacter ethanolicus Jian et al. 2016, Celeribacter sp. NH195, JCM 31095, strain NH195
Server load: low (32%) [HD]