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| | SGUI_1279 | Signal peptidase protein. (123 aa) |
| | SGUI_0075 | Alkylated DNA repair protein AlkB. (239 aa) |
| | recO | DNA recombination and repair protein RecO; Involved in DNA repair and RecF pathway recombination. (243 aa) |
| | SGUI_0102 | ATP-dependent DNA ligase. (320 aa) |
| | SGUI_0122 | Hypothetical protein. (297 aa) |
| | SGUI_0137 | Hypothetical protein. (118 aa) |
| | SGUI_0158 | DNA-3-methyladenine glycosylase II; Belongs to the DNA glycosylase MPG family. (209 aa) |
| | SGUI_0165 | DNA repair protein RecN. (629 aa) |
| | SGUI_0172 | ADP-ribose pyrophosphatase. (201 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (898 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (702 aa) |
| | uvrA | Excinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (988 aa) |
| | uvrC | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (639 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (479 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (385 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (202 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (223 aa) |
| | SGUI_0514 | ATP-dependent DNA ligase LigC. (359 aa) |
| | SGUI_0516 | ATP-dependent DNA ligase. (358 aa) |
| | SGUI_0742 | Photolyase protein family. (489 aa) |
| | dinB-2 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (388 aa) |
| | SGUI_0800 | DNA polymerase III alpha subunit; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1352 aa) |
| | lexA | SOS-response repressor and protease LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (242 aa) |
| | SGUI_0974 | Competence protein ComEA helix-hairpin-helix repeat protein. (310 aa) |
| | SGUI_1014 | Hypothetical protein. (405 aa) |
| | SGUI_1035 | Hypothetical protein. (313 aa) |
| | SGUI_1075 | Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (278 aa) |
| | SGUI_1116 | DNA polymerase-like protein. (347 aa) |
| | ligA | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (716 aa) |
| | SGUI_1327 | Uracil-DNA glycosylase, family 5. (275 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1215 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (413 aa) |
| | disA | DNA integrity scanning protein DisA; Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. (360 aa) |
| | SGUI_1442 | A/G-specific adenine glycosylase. (304 aa) |
| | ku | Ku domain protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (305 aa) |
| | SGUI_1449 | ATP-dependent DNA ligase clustered with Ku protein, LigD. (307 aa) |
| | SGUI_1450 | ATP-dependent DNA ligase clustered with Ku protein, LigD. (282 aa) |
| | SGUI_1454 | Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. (168 aa) |
| | SGUI_1455 | Methylated-DNA--protein-cysteine methyltransferase. (516 aa) |
| | SGUI_1491 | Putative helicase. (737 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (247 aa) |
| | recR | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (200 aa) |
| | SGUI_1533 | Hypothetical protein. (343 aa) |
| | SGUI_1549 | Endonuclease IV. (353 aa) |
| | SGUI_1552 | Exodeoxyribonuclease III. (265 aa) |
| | SGUI_1554 | Hypothetical protein. (193 aa) |
| | SGUI_1602 | Excinuclease ABC subunit A. (810 aa) |
| | SGUI_1713 | Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (286 aa) |
| | SGUI_1762 | Formamidopyrimidine-DNA glycosylase. (283 aa) |
| | SGUI_1778 | ATP-dependent DNA ligase LigC; Belongs to the ATP-dependent DNA ligase family. (560 aa) |
| | SGUI_1807 | Exodeoxyribonuclease III. (306 aa) |
| | SGUI_1810 | Excinuclease ABC subunit A. (785 aa) |
| | recF | DNA recombination and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. (414 aa) |
| | SGUI_2073 | Putative cytoplasmic protein clustered with trehalase. (379 aa) |
| | SGUI_2150 | Putative RecF protein. (407 aa) |
| | SGUI_2233 | Insertion element IS1415 transposase. (189 aa) |
| | recD | Exodeoxyribonuclease V alpha chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (673 aa) |
| | recB | Exodeoxyribonuclease V beta chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repai [...] (1139 aa) |
| | recC | Exodeoxyribonuclease V gamma chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (1169 aa) |
| | SGUI_2561 | DNA-dependent DNA polymerase beta chain. (358 aa) |
| | SGUI_2592 | Putative hydrolase mutT1. (316 aa) |
| | SGUI_2596 | Hypothetical protein; May play a role in the intracellular transport of hydrophobic ligands. (164 aa) |
| | ung | Uracil-DNA glycosylase, family 1; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (225 aa) |
| | SGUI_2988 | Putative mutT-like protein; Belongs to the Nudix hydrolase family. (134 aa) |
| | SGUI_2998 | DNA-3-methyladenine glycosylase. (218 aa) |
| | SGUI_3020 | ATP-dependent DNA helicase. (1066 aa) |
| | SGUI_3021 | ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. (1096 aa) |
| | SGUI_3141 | Formamidopyrimidine-DNA glycosylase. (279 aa) |
| | recA | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (364 aa) |
| | mutM | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (297 aa) |
| | SGUI_3266 | G:T/U mismatch-specific uracil/thymine DNA-glycosylase. (203 aa) |
