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| | SGUI_2489 | Serine acetyltransferase. (207 aa) |
| | SGUI_0033 | D-3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (396 aa) |
| | serC | Phosphoserine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (359 aa) |
| | proB | Glutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (374 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (427 aa) |
| | SGUI_0091 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (424 aa) |
| | SGUI_0113 | 3-oxoacyl-[acyl-carrier-protein] synthase, KASII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (418 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family. (82 aa) |
| | fabH | 3-oxoacyl-[acyl-carrier-protein] synthase, KASIII; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (343 aa) |
| | SGUI_0116 | Malonyl CoA-acyl carrier protein transacylase. (309 aa) |
| | SGUI_0138 | Glutamine synthetase type I. (442 aa) |
| | SGUI_0140 | Hypothetical protein. (213 aa) |
| | SGUI_0141 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Acting phosphoribosylanthranilate isomerase; Belongs to the HisA/HisF family. (235 aa) |
| | argR | Arginine pathway regulatory protein ArgR, repressor of arg regulon; Regulates arginine biosynthesis genes. (200 aa) |
| | argH | Argininosuccinate lyase. (473 aa) |
| | SGUI_0181 | Shikimate 5-dehydrogenase I alpha; Belongs to the shikimate dehydrogenase family. (279 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (420 aa) |
| | aroK | Shikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (170 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (372 aa) |
| | carA | Carbamoyl-phosphate synthase small chain; Belongs to the CarA family. (385 aa) |
| | carB | Carbamoyl-phosphate synthase large chain; Belongs to the CarB family. (1114 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (274 aa) |
| | trpB | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (424 aa) |
| | trpA | Tryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (261 aa) |
| | SGUI_0239 | Glutamate synthase [NADPH] small chain. (461 aa) |
| | SGUI_0240 | Glutamate synthase [NADPH] large chain. (1528 aa) |
| | SGUI_0279 | Enoyl-[acyl-carrier-protein] reductase [NADH]. (251 aa) |
| | SGUI_0317 | Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase. (485 aa) |
| | SGUI_0364 | Oxidoreductase of aldo/keto reductase family, subgroup 1. (274 aa) |
| | SGUI_0375 | Homocysteine S-methyltransferase. (336 aa) |
| | SGUI_0404 | Acetylornithine deacetylase. (399 aa) |
| | hisI | Phosphoribosyl-AMP cyclohydrolase; Phosphoribosyl-ATP pyrophosphatase; In the N-terminal section; belongs to the PRA-CH family. (206 aa) |
| | hisF | Imidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (257 aa) |
| | hisA | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (264 aa) |
| | hisH | Imidazole glycerol phosphate synthase amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (200 aa) |
| | hisB | Histidinol-phosphatase; Imidazoleglycerol-phosphate dehydratase; Belongs to the imidazoleglycerol-phosphate dehydratase family. In the N-terminal section; belongs to the histidinol- phosphatase family. (365 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (376 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (435 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (302 aa) |
| | SGUI_0449 | Hypothetical protein. (177 aa) |
| | SGUI_0467 | Aminodeoxychorismate lyase. (311 aa) |
| | SGUI_0471 | Xylitol oxidase. (417 aa) |
| | SGUI_0485 | Conserved hypothetical protein potentially related to ribose or hydroxymethylpyrimidine metabolism. (399 aa) |
| | SGUI_0518 | Pyrroline-5-carboxylate reductase. (273 aa) |
| | SGUI_0529 | Sulfite reductase [NADPH] flavoprotein alpha-component; Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L-cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH -> FAD -> FMN to the hemoprotein component. (603 aa) |
| | SGUI_0603 | N-acetyl-L,L-diaminopimelate deacetylase. (422 aa) |
| | SGUI_0610 | 5'-methylthioadenosine nucleosidase; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (232 aa) |
| | SGUI_0615 | N-acetyl-L,L-diaminopimelate deacetylase. (402 aa) |
| | SGUI_0651 | Homoserine O-acetyltransferase; Belongs to the AB hydrolase superfamily. MetX family. (356 aa) |
| | SGUI_0659 | Putative oxidoreductase, Zn-binding. (322 aa) |
| | SGUI_0709 | TPP-requiring enzyme. (92 aa) |
| | SGUI_0712 | TPP-requiring enzyme; Belongs to the TPP enzyme family. (550 aa) |
| | SGUI_0724 | Tartrate dehydrogenase. (363 aa) |
| | SGUI_0728 | Tartrate dehydrogenase. (355 aa) |
| | SGUI_0736 | Pyruvate oxidase; Belongs to the TPP enzyme family. (576 aa) |
| | SGUI_0737 | Ferredoxin-dependent glutamate synthase; Belongs to the glutamate synthase family. (539 aa) |
| | SGUI_0739 | N-acetyl-L,L-diaminopimelate deacetylase. (411 aa) |
| | SGUI_0740 | Carboxypeptidase G2. (385 aa) |
| | aroQ | 3-dehydroquinate dehydratase II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (158 aa) |
| | SGUI_0810 | 2-keto-3-deoxy-D-arabino-heptulosonate-7- phosphate synthase II; Belongs to the class-II DAHP synthase family. (455 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (360 aa) |
| | SGUI_0828 | Quinone oxidoreductase. (323 aa) |
| | SGUI_0837 | Catalyzes the cleavage of p-aminobenzoyl-glutamate to p-aminobenzoate and glutamate, subunit A. (461 aa) |
| | lipA | Lipoate synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (350 aa) |
| | SGUI_0853 | Glutamine synthetase type I. (474 aa) |
| | SGUI_0859 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa) |
| | SGUI_0915 | Dihydrofolate reductase. (191 aa) |
| | SGUI_1023 | Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (413 aa) |
| | SGUI_1050 | Acetyl-coenzyme A carboxyl transferase beta chain; Propionyl-CoA carboxylase beta chain. (539 aa) |
| | SGUI_1095 | Dihydrofolate synthase. (492 aa) |
| | SGUI_1154 | Chorismate mutase I; Cyclohexadienyl dehydrogenase. (380 aa) |
| | kbl | 2-amino-3-ketobutyrate coenzyme A ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (397 aa) |
| | thrB | Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (317 aa) |
| | SGUI_1168 | Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine. (364 aa) |
| | SGUI_1173 | Membrane protein. (237 aa) |
| | SGUI_1190 | Branched-chain amino acid aminotransferase. (366 aa) |
| | SGUI_1191 | Ketol-acid reductoisomerase. (265 aa) |
| | SGUI_1210 | Methionine synthase, vitamin-B12 independent, putative. (331 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (429 aa) |
| | SGUI_1265 | Homoserine dehydrogenase. (333 aa) |
| | SGUI_1270 | Selenide,water dikinase. (342 aa) |
| | pheA | Prephenate dehydratase. (302 aa) |
| | SGUI_1283 | 3-isopropylmalate dehydrogenase. (374 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (478 aa) |
| | leuD | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (199 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (581 aa) |
| | acpS | Holo-[acyl-carrier protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (125 aa) |
| | SGUI_1316 | CDP-glycerol:poly(glycerophosphate) glycerophosphotransferase. (899 aa) |
| | SGUI_1319 | 3-oxoacyl-[ACP] synthase III in alkane synthesis cluster. (340 aa) |
| | SGUI_1373 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (338 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (267 aa) |
| | SGUI_1464 | Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (300 aa) |
| | SGUI_1465 | Dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (281 aa) |
| | SGUI_1485 | O-succinylhomoserine sulfhydrylase. (401 aa) |
| | SGUI_1568 | Threonine dehydratase, catabolic. (332 aa) |
| | SGUI_1579 | Branched-chain amino acid aminotransferase. (312 aa) |
| | SGUI_1613 | Bifunctional deaminase-reductase domain protein. (189 aa) |
| | SGUI_1616 | Cysteine synthase B; Belongs to the cysteine synthase/cystathionine beta- synthase family. (304 aa) |
| | SGUI_1617 | Hypothetical protein. (313 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | SGUI_1753 | Glutamine synthetase family protein. (454 aa) |
| | SGUI_1846 | Carbamoylphosphate synthase large subunit. (405 aa) |
| | SGUI_1895 | Hypothetical protein. (887 aa) |
| | SGUI_1909 | UDP-glucose dehydrogenase. (388 aa) |
| | SGUI_1977 | Dihydrofolate reductase. (186 aa) |
| | SGUI_1997 | Dihydrofolate reductase. (184 aa) |
| | SGUI_2075 | Betaine--homocysteine S-methyltransferase. (361 aa) |
| | SGUI_2185 | Aminoglycoside phosphotransferase. (332 aa) |
| | SGUI_2200 | Dihydrofolate reductase. (193 aa) |
| | SGUI_2245 | Sulfur carrier protein adenylyltransferase ThiF. (380 aa) |
| | ilvA | Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (425 aa) |
| | SGUI_2292 | Cystathionine gamma-synthase. (365 aa) |
| | SGUI_2307 | Quinone oxidoreductase. (329 aa) |
| | SGUI_2337 | N-formylglutamate deformylase. (417 aa) |
| | SGUI_2371 | Bifunctional protein: zinc-containing alcohol dehydrogenase; Quinone oxidoreductase (NADPH:quinone reductase); Similar to arginate lyase. (310 aa) |
| | SGUI_2374 | Diaminopimelate decarboxylase. (398 aa) |
| | SGUI_2376 | 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Belongs to the transferase hexapeptide repeat family. (281 aa) |
| | dapB | 4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (233 aa) |
| | SGUI_2388 | Glycerol-3-phosphate cytidylyltransferase. (151 aa) |
| | metZ | O-acetylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (383 aa) |
| | SGUI_2444 | Hypothetical protein. (797 aa) |
| | SGUI_2484 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (440 aa) |
| | SGUI_2488 | Cysteine synthase; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa) |
| | SGUI_2516 | Glutamine amidotransferases class-II. (275 aa) |
| | metXA | Homoserine O-acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (390 aa) |
| | SGUI_2552 | Acetolactate synthase large subunit. (601 aa) |
| | SGUI_2553 | Acetolactate synthase small subunit. (146 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (345 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (566 aa) |
| | SGUI_2566 | Oxidoreductase of aldo/keto reductase family, subgroup 1. (274 aa) |
| | SGUI_2588 | 5-methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1230 aa) |
| | SGUI_2842 | Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (406 aa) |
| | SGUI_2853 | Acyl dehydratase. (298 aa) |
| | SGUI_2856 | Hypothetical protein. (129 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 2 subfamily. (497 aa) |
| | SGUI_2933 | Putative dehydrogenase. (324 aa) |
| | SGUI_2973 | Prophage Lp1 protein 5. (232 aa) |
| | SGUI_3035 | Histidinol-phosphatase. (274 aa) |
| | aroA | 5-Enolpyruvylshikimate-3-phosphate synthase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (474 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (NADP+); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (287 aa) |
| | SGUI_3091 | Peptidase M20D, amidohydrolase. (418 aa) |
| | SGUI_3119 | Methylcrotonyl-CoA carboxylase carboxyl transferase subunit. (531 aa) |
| | SGUI_3149 | Acetyl-coenzyme A carboxyl transferase beta chain. (657 aa) |
| | asd | Aspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (377 aa) |
| | SGUI_3155 | Aspartokinase; Belongs to the aspartokinase family. (423 aa) |
| | SGUI_3210 | Dihydrofolate reductase. (125 aa) |
| | SGUI_3211 | Dihydrofolate reductase. (61 aa) |
| | SGUI_3276 | Phosphoserine phosphatase. (291 aa) |
