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| | SGUI_2657 | Mobile element protein. (258 aa) |
| | SGUI_2690 | YoeB toxin protein. (122 aa) |
| | SGUI_2719 | McrBC 5-methylcytosine restriction system component-like. (398 aa) |
| | SGUI_2720 | Endonuclease. (667 aa) |
| | proS | Prolyl-tRNA synthetase, bacterial type; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing [...] (595 aa) |
| | truB | tRNA pseudouridine synthase B; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (297 aa) |
| | SGUI_0035 | Cytoplasmic axial filament protein CafA and Ribonuclease G. (924 aa) |
| | trmB | tRNA (guanine46-N7-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (271 aa) |
| | ybeY | Metal-dependent hydrolase YbeY, involved in rRNA and/or ribosome maturation and assembly; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (172 aa) |
| | glyQS | Glycyl-tRNA synthetase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (456 aa) |
| | SGUI_0088 | tRNA dihydrouridine synthase B. (403 aa) |
| | SGUI_0102 | ATP-dependent DNA ligase. (320 aa) |
| | dnaG | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (644 aa) |
| | SGUI_0124 | Phosphoglycerate mutase family. (391 aa) |
| | SGUI_0127 | 3'-to-5' exoribonuclease RNase R. (486 aa) |
| | SGUI_0150 | tRNA (guanosine(18)-2'-O)-methyltransferase; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (271 aa) |
| | pheS | Phenylalanyl-tRNA synthetase alpha chain; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (386 aa) |
| | pheT | Phenylalanyl-tRNA synthetase beta chain; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (845 aa) |
| | SGUI_0158 | DNA-3-methyladenine glycosylase II; Belongs to the DNA glycosylase MPG family. (209 aa) |
| | tyrS | Tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily. (420 aa) |
| | aspS | Aspartyl-tRNA synthetase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (600 aa) |
| | alaS | Alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (896 aa) |
| | rpoZ | DNA-directed RNA polymerase omega subunit; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (89 aa) |
| | priA | Helicase PriA essential for oriC/DnaA-independent DNA replication; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (708 aa) |
| | fmt | Methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (313 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (898 aa) |
| | uvrB | Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (702 aa) |
| | uvrC | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (639 aa) |
| | SGUI_0287 | rRNA methyltransferase. (284 aa) |
| | SGUI_0290 | YbaK/prolyl-tRNA synthetase associated region. (184 aa) |
| | dinB | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (479 aa) |
| | SGUI_0329 | Protein-L-isoaspartate methyltransferase; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (332 aa) |
| | SGUI_0345 | Putative helicase. (974 aa) |
| | SGUI_0348 | DNA polymerase I. (322 aa) |
| | SGUI_0351 | Cys-tRNA(Pro) deacylase YbaK; Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. (164 aa) |
| | SGUI_0377 | 23S rRNA (Uracil-5-) -methyltransferase rumB; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (378 aa) |
| | SGUI_0419 | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. (313 aa) |
| | xerD | Site-specific recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (325 aa) |
| | hisS | Histidyl-tRNA synthetase. (466 aa) |
| | ruvB | Holliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (385 aa) |
| | ruvA | Holliday junction DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (202 aa) |
| | ruvC | Crossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (223 aa) |
| | thrS | Threonyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family. (661 aa) |
| | SGUI_0504 | dolichol-P-glucose synthetase. (300 aa) |
| | SGUI_0514 | ATP-dependent DNA ligase LigC. (359 aa) |
| | SGUI_0516 | ATP-dependent DNA ligase. (358 aa) |
| | SGUI_0523 | Ribonuclease D. (416 aa) |
| | SGUI_0542 | Hypothetical protein. (142 aa) |
| | SGUI_0586 | 23S rRNA (Uracil-5-) -methyltransferase RumA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (453 aa) |
| | SGUI_0613 | Topoisomerase IV subunit A. (826 aa) |
| | SGUI_0668 | Hypothetical protein. (52 aa) |
| | SGUI_0673 | Hypothetical protein. (60 aa) |
| | SGUI_0674 | Hypothetical protein. (48 aa) |
| | SGUI_0675 | Putative helicase. (1128 aa) |
| | SGUI_0682 | Superfamily II DNA/RNA helicase, SNF2 family. (879 aa) |
| | SGUI_0689 | Putative rRNA methylase. (281 aa) |
| | vapC-2 | Hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (128 aa) |
| | SGUI_0758 | Putative helicase. (1102 aa) |
| | SGUI_0760 | ATP-dependent RNA helicase. (505 aa) |
| | SGUI_0789 | ATP-dependent RNA helicase. (766 aa) |
| | SGUI_0790 | Topoisomerase IV subunit B. (702 aa) |
| | dinB-2 | DNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (388 aa) |
| | SGUI_0800 | DNA polymerase III alpha subunit; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1352 aa) |
| | SGUI_0803 | Mobile element protein. (361 aa) |
| | SGUI_0819 | DNA polymerase III epsilon subunit. (598 aa) |
| | SGUI_0835 | Tryptophanyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (379 aa) |
| | SGUI_0856 | Superfamily I DNA and RNA helicase. (1158 aa) |
| | SGUI_0865 | DNA polymerase III alpha subunit. (1370 aa) |
| | SGUI_0867 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (309 aa) |
| | rsmH | rRNA small subunit methyltransferase H; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (336 aa) |
| | vapC-3 | Hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (127 aa) |
| | SGUI_0910 | ATP-dependent helicase hrpA. (1346 aa) |
| | SGUI_0946 | DNA/RNA helicase of DEAD/DEAH box family. (1012 aa) |
| | SGUI_0960 | ATP-dependent DNA helicase RecQ. (734 aa) |
| | leuS | Leucyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (975 aa) |
| | SGUI_0983 | DinG family ATP-dependent helicase YoaA. (733 aa) |
| | miaA | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (311 aa) |
| | SGUI_1014 | Hypothetical protein. (405 aa) |
| | SGUI_1035 | Hypothetical protein. (313 aa) |
| | SGUI_1073 | Hypothetical protein. (331 aa) |
| | SGUI_1075 | Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (278 aa) |
| | ileS | Isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (1141 aa) |
| | SGUI_1100 | Hypothetical protein. (283 aa) |
| | valS | Valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner. (897 aa) |
| | SGUI_1116 | DNA polymerase-like protein. (347 aa) |
| | SGUI_1149 | Ribosomal large subunit pseudouridine synthase A. (288 aa) |
| | orn | 3'-to-5' oligoribonuclease (orn); 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family. (203 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (264 aa) |
| | vapC-4 | PIN domain protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (125 aa) |
| | SGUI_1185 | Toxin 1, PIN domain. (106 aa) |
| | gatB | Aspartyl-tRNA(Asn) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (519 aa) |
| | gatA | Aspartyl-tRNA(Asn) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). (512 aa) |
| | gatC | Aspartyl-tRNA(Asn) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family. (98 aa) |
| | ligA | DNA ligase; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (716 aa) |
| | nucS | Hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (234 aa) |
| | rho | Transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (666 aa) |
| | argS | Arginyl-tRNA synthetase. (555 aa) |
| | selA | L-seryl-tRNA(Sec) selenium transferase; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (472 aa) |
| | SGUI_1327 | Uracil-DNA glycosylase, family 5. (275 aa) |
| | mfd | Transcription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1215 aa) |
| | pth | Peptidyl-tRNA hydrolase; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. Belongs to the PTH family. (199 aa) |
| | rsmA | SSU rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (423 aa) |
| | SGUI_1355 | Methionyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (565 aa) |
| | rsmI | rRNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (281 aa) |
| | SGUI_1384 | Superfamily I DNA and RNA helicase. (1185 aa) |
| | hemA | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (465 aa) |
| | radA | DNA repair protein RadA; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (413 aa) |
| | SGUI_1442 | A/G-specific adenine glycosylase. (304 aa) |
| | SGUI_1449 | ATP-dependent DNA ligase clustered with Ku protein, LigD. (307 aa) |
| | SGUI_1450 | ATP-dependent DNA ligase clustered with Ku protein, LigD. (282 aa) |
| | lysS | Lysyl-tRNA synthetase (class II); Belongs to the class-II aminoacyl-tRNA synthetase family. (500 aa) |
| | SGUI_1455 | Methylated-DNA--protein-cysteine methyltransferase. (516 aa) |
| | SGUI_1477 | DNA polymerase III delta prime subunit. (387 aa) |
| | topA | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (900 aa) |
| | SGUI_1491 | Putative helicase. (737 aa) |
| | nth | Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (247 aa) |
| | dnaX | DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (770 aa) |
| | SGUI_1523 | Putative helicase protein. (748 aa) |
| | SGUI_1533 | Hypothetical protein. (343 aa) |
| | SGUI_1544 | SpoU rRNA methylase family protein. (214 aa) |
| | SGUI_1549 | Endonuclease IV. (353 aa) |
| | SGUI_1552 | Exodeoxyribonuclease III. (265 aa) |
| | vapC-5 | Toxin 1, PIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (144 aa) |
| | SGUI_1651 | Putative ribonuclease. (194 aa) |
| | vapC-6 | Toxin 1, PIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (142 aa) |
| | SGUI_1661 | 23S rRNA (guanosine-2'-O-) -methyltransferase rlmB. (267 aa) |
| | serS | Seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (426 aa) |
| | SGUI_1713 | Formamidopyrimidine-DNA glycosylase; Belongs to the FPG family. (286 aa) |
| | SGUI_1762 | Formamidopyrimidine-DNA glycosylase. (283 aa) |
| | SGUI_1778 | ATP-dependent DNA ligase LigC; Belongs to the ATP-dependent DNA ligase family. (560 aa) |
| | SGUI_1807 | Exodeoxyribonuclease III. (306 aa) |
| | SGUI_1849 | Hypothetical protein. (185 aa) |
| | gyrA | DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (900 aa) |
| | gyrB | DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (732 aa) |
| | SGUI_1871 | DNA polymerase III beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (377 aa) |
| | rnpA | Ribonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (111 aa) |
| | rsmG | rRNA small subunit 7-methylguanosine (m7G) methyltransferase GidB; Specifically methylates the N7 position of a guanine in 16S rRNA; Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family. (243 aa) |
| | SGUI_1927 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (885 aa) |
| | SGUI_1929 | DNA polymerase III epsilon subunit. (281 aa) |
| | SGUI_1949 | Mobile element protein. (71 aa) |
| | SGUI_1950 | Mobile element protein. (115 aa) |
| | vapC-7 | PilT protein, N-terminal; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (131 aa) |
| | vapC-8 | Toxin 1, PIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (131 aa) |
| | vapC-9 | Hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (129 aa) |
| | vapC-10 | Toxin 1, PIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (130 aa) |
| | SGUI_2040 | Methyltransferase. (244 aa) |
| | SGUI_2062 | Toxin 1, PIN domain. (126 aa) |
| | SGUI_2073 | Putative cytoplasmic protein clustered with trehalase. (379 aa) |
| | SGUI_2210 | Mobile element protein. (107 aa) |
| | SGUI_2211 | Mobile element protein. (258 aa) |
| | SGUI_2233 | Insertion element IS1415 transposase. (189 aa) |
| | SGUI_2286 | Death on curing protein, Doc toxin. (137 aa) |
| | SGUI_2301 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (190 aa) |
| | vapC-11 | Hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (132 aa) |
| | SGUI_2324 | Protein RtcB. (390 aa) |
| | SGUI_2336 | YbaK/prolyl-tRNA synthetase associated region. (163 aa) |
| | SGUI_2340 | Mobile element protein. (294 aa) |
| | SGUI_2342 | Mobile element protein. (294 aa) |
| | recD | Exodeoxyribonuclease V alpha chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (673 aa) |
| | recB | Exodeoxyribonuclease V beta chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repai [...] (1139 aa) |
| | recC | Exodeoxyribonuclease V gamma chain; A helicase/nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repa [...] (1169 aa) |
| | vapC-12 | Hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (130 aa) |
| | vapC-13 | Toxin 1, PIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (129 aa) |
| | SGUI_2457 | Hypothetical protein. (104 aa) |
| | SGUI_2473 | Hypothetical protein. (110 aa) |
| | vapC-14 | Hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (129 aa) |
| | SGUI_2561 | DNA-dependent DNA polymerase beta chain. (358 aa) |
| | SGUI_2582 | Putative helicase. (870 aa) |
| | dtd | D-tyrosyl-tRNA(Tyr) deacylase; An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA- based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D- aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl- tRNA entities in vivo and helps enforce protein L-homochirality. Belongs to the DTD family. (141 aa) |
| | cysS | Cysteinyl-tRNA synthetase; Belongs to the class-I aminoacyl-tRNA synthetase family. (488 aa) |
| | SGUI_2628 | 23S rRNA (guanosine-2'-O-) -methyltransferase rlmB; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. (317 aa) |
| | SGUI_2647 | Mobile element protein. (363 aa) |
| | SGUI_2653 | Phage-related integrase/recombinase. (371 aa) |
| | SGUI_2655 | Mobile element protein. (221 aa) |
| | SGUI_2656 | Mobile element protein. (79 aa) |
| | ung | Uracil-DNA glycosylase, family 1; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (225 aa) |
| | SGUI_2747 | Putative ATP/GTP-binding protein. (683 aa) |
| | SGUI_2758 | DNA repair helicase. (556 aa) |
| | SGUI_2772 | Putative DNA-binding protein. (751 aa) |
| | vapC-15 | Toxin 1, PIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (145 aa) |
| | SGUI_2875 | Type I restriction-modification system, DNA-methyltransferase subunit M. (541 aa) |
| | SGUI_2877 | Type I restriction-modification system, restriction subunit R; Subunit R is required for both nuclease and ATPase activities, but not for modification. (1064 aa) |
| | SGUI_2878 | Hypothetical protein. (323 aa) |
| | rpoB | DNA-directed RNA polymerase beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1147 aa) |
| | rpoC | DNA-directed RNA polymerase beta' subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1308 aa) |
| | rpoA | DNA-directed RNA polymerase alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (340 aa) |
| | SGUI_2931 | tRNA pseudouridine synthase A; Belongs to the tRNA pseudouridine synthase TruA family. (90 aa) |
| | truA | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (287 aa) |
| | xseB | Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (90 aa) |
| | xseA | Exodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (411 aa) |
| | SGUI_2998 | DNA-3-methyladenine glycosylase. (218 aa) |
| | SGUI_3016 | Putative ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (496 aa) |
| | SGUI_3020 | ATP-dependent DNA helicase. (1066 aa) |
| | SGUI_3021 | ATP-dependent DNA helicase; Belongs to the helicase family. UvrD subfamily. (1096 aa) |
| | SGUI_3024 | ATP-dependent DNA helicase UvrD/PcrA. (707 aa) |
| | SGUI_3067 | Hypothetical protein. (358 aa) |
| | SGUI_3070 | ATP-dependent DNA helicase UvrD/PcrA. (845 aa) |
| | rnj | Ribonuclease J2 (endoribonuclease in RNA processing); An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (561 aa) |
| | SGUI_3141 | Formamidopyrimidine-DNA glycosylase. (279 aa) |
| | SGUI_3145 | Putative ATP-dependent helicase lhr. (1699 aa) |
| | SGUI_3156 | Maebl. (366 aa) |
| | recA | RecA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (364 aa) |
| | SGUI_3201 | Site-specific recombinase XerD; Belongs to the 'phage' integrase family. (309 aa) |
| | gltX | Glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (510 aa) |
| | SGUI_3232 | Transposon Tn21 resolvase. (202 aa) |
| | SGUI_3245 | ATP-dependent DNA helicase RecG. (771 aa) |
| | rnc | Ribonuclease III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (250 aa) |
| | mutM | Formamidopyrimidine-DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (297 aa) |
| | SGUI_3259 | Putative ABC transporter. (245 aa) |
| | vapC-16 | Toxin 1, PIN domain; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (146 aa) |
| | SGUI_3266 | G:T/U mismatch-specific uracil/thymine DNA-glycosylase. (203 aa) |
| | trmD | tRNA (Guanine37-N1) -methyltransferase; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (244 aa) |
| | SGUI_3279 | Ribonuclease HII; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (242 aa) |
| | xerC | Tyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (307 aa) |
| | rlmN | Ribosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (389 aa) |
