STRINGSTRING
KTE30048.1 KTE30048.1 KTE30062.1 KTE30062.1 KTE28603.1 KTE28603.1 pyrB pyrB KTE27756.1 KTE27756.1 KTE26950.1 KTE26950.1 KTE24654.1 KTE24654.1 rutB rutB KTE46432.1 KTE46432.1 KTE46559.1 KTE46559.1 KTE46567.1 KTE46567.1 KTE46579.1 KTE46579.1 KTE44191.1 KTE44191.1 tdk tdk KTE43659.1 KTE43659.1 KTE43010.1 KTE43010.1 KTE43020.1 KTE43020.1 KTE43021.1 KTE43021.1 cmk cmk KTE42395.1 KTE42395.1 KTE42407.1 KTE42407.1 KTE41928.1 KTE41928.1 pyrC pyrC surE surE pyrD pyrD KTE40055.1 KTE40055.1 pyrH pyrH carB carB carA carA dut dut KTE38580.1 KTE38580.1 KTE38380.1 KTE38380.1 KTE37932.1 KTE37932.1 KTE37407.1 KTE37407.1 KTE37439.1 KTE37439.1 pyrE pyrE ATE62_14715 ATE62_14715 dcd dcd KTE36458.1 KTE36458.1 KTE36465.1 KTE36465.1 KTE35892.1 KTE35892.1 KTE35327.1 KTE35327.1 ATE62_15485 ATE62_15485 pyrG pyrG nrdR nrdR KTE34619.1 KTE34619.1 groS groS KTE33471.1 KTE33471.1 KTE33484.1 KTE33484.1 thyA thyA ndk ndk pyrF pyrF tgt tgt tmk tmk mazG mazG KTE30414.1 KTE30414.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KTE30048.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (498 aa)
KTE30062.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
KTE28603.1Lysine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; Catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (331 aa)
KTE27756.1Dihydroorotase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
KTE26950.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
KTE24654.1Nuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
rutBPyrimidine utilization protein B; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. (241 aa)
KTE46432.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
KTE46559.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (188 aa)
KTE46567.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (486 aa)
KTE46579.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
KTE44191.1Phosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
tdkThymidine kinase; Catalyzes the formation of thymidine 5'-phosphate from thymidine; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
KTE43659.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
KTE43010.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (412 aa)
KTE43020.1Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (650 aa)
KTE43021.1Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (353 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
KTE42395.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (143 aa)
KTE42407.1Sugar transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
KTE41928.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (188 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (339 aa)
surEStationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (257 aa)
pyrDDihydroorotate dehydrogenase 2; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (356 aa)
KTE40055.1Malonic semialdehyde reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (197 aa)
pyrHUridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1106 aa)
carACarbamoyl-phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (398 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (190 aa)
KTE38580.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (452 aa)
KTE38380.1Sodium:melibiose symporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
KTE37932.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
KTE37407.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
KTE37439.1SAM-dependent methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methyltransferase superfamily. (292 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (193 aa)
ATE62_14715Uncharacterized protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (455 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (184 aa)
KTE36458.1Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (149 aa)
KTE36465.1Enamine deaminase RidA; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
KTE35892.1Enamine deaminase RidA; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
KTE35327.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
ATE62_15485Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (440 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (543 aa)
nrdRNrdR family transcriptional regulator; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (154 aa)
KTE34619.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
groSMolecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa)
KTE33471.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
KTE33484.1Decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (193 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (319 aa)
ndkPhosphodiesterase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (224 aa)
tgtQueuine tRNA-ribosyltransferase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form t [...] (377 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (207 aa)
mazGNucleoside triphosphate hydrolase; Functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
KTE30414.1Pyrimidine utilization protein C; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the RutC family. (127 aa)
Your Current Organism:
Sphingopyxis sp. HIX
NCBI taxonomy Id: 1759074
Other names: S. sp. HIX
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