STRINGSTRING
AKQ99789.1 AKQ99789.1 purA purA AKQ99954.1 AKQ99954.1 AKR00076.1 AKR00076.1 AKR00157.1 AKR00157.1 adk adk purD purD AKR00391.1 AKR00391.1 purC purC purS purS purQ purQ purL purL cpdA cpdA AKR00424.1 AKR00424.1 purM purM purN purN AKR00598.1 AKR00598.1 prs prs AKR00671.1 AKR00671.1 AKR00676.1 AKR00676.1 AKR00953.1 AKR00953.1 cysD cysD cysN cysN AKR01018.1 AKR01018.1 AKR01019.1 AKR01019.1 AKR01020.1 AKR01020.1 AKR01041.1 AKR01041.1 gmk gmk AKR01332.1 AKR01332.1 AKR01340.1 AKR01340.1 AKR01590.1 AKR01590.1 ureA ureA ureB ureB AKR01597.1 AKR01597.1 AKR01980.1 AKR01980.1 AKR02147.1 AKR02147.1 ndk ndk AKR02416.1 AKR02416.1 apt apt AKR02448.1 AKR02448.1 AKR02915.1 AKR02915.1 AKR02918.1 AKR02918.1 AKR02939.1 AKR02939.1 AKR03177.1 AKR03177.1 purK purK AKR03210.1 AKR03210.1 AKR03218.1 AKR03218.1 AKR03308.1 AKR03308.1 guaA guaA AKR03326.1 AKR03326.1 AKR03327.1 AKR03327.1 AKR03544.1 AKR03544.1 AKR03568.1 AKR03568.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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AKQ99789.1Ribonucleotide-diphosphate reductase subunit beta. (314 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (432 aa)
AKQ99954.1Phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family. (419 aa)
AKR00076.1Hypothetical protein. (344 aa)
AKR00157.1Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (710 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (181 aa)
purDPhosphoribosylamine--glycine ligase; Belongs to the GARS family. (422 aa)
AKR00391.1Adenylosuccinate lyase. (472 aa)
purCPhosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (297 aa)
purSPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (79 aa)
purQPhosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (224 aa)
purLPhosphoribosylformylglycinamidine synthase subunit PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought [...] (754 aa)
cpdA3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (318 aa)
AKR00424.1Amidophosphoribosyltransferase. (527 aa)
purMPhosphoribosylaminoimidazole synthetase. (364 aa)
purNPhosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (215 aa)
AKR00598.1Bifunctional purine biosynthesis protein PurH. (523 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (326 aa)
AKR00671.1Nucleoside triphosphate pyrophosphohydrolase. (325 aa)
AKR00676.1Hypothetical protein. (319 aa)
AKR00953.1Adenylyl cyclase. (397 aa)
cysDSulfate adenylyltransferase. (332 aa)
cysNBifunctional enzyme CysN/CysC; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (614 aa)
AKR01018.1Adenylate cyclase. (541 aa)
AKR01019.1Adenylate cyclase. (535 aa)
AKR01020.1Adenylate cyclase. (567 aa)
AKR01041.1Nucleoside-triphosphate diphosphatase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (201 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (208 aa)
AKR01332.1Pyruvate kinase; Belongs to the pyruvate kinase family. (472 aa)
AKR01340.1Adenylate cyclase; Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. (443 aa)
AKR01590.1Inosine-5'-monophosphate dehydrogenase. (479 aa)
ureAUrease subunit gamma; Belongs to the urease gamma subunit family. (100 aa)
ureBUrease subunit beta; Belongs to the urease beta subunit family. (104 aa)
AKR01597.1Urease subunit alpha. (577 aa)
AKR01980.1Adenosine kinase. (324 aa)
AKR02147.1Deoxyguanosinetriphosphate triphosphohydrolase-like protein; Belongs to the dGTPase family. Type 2 subfamily. (431 aa)
ndkNucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (136 aa)
AKR02416.1GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. (790 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (171 aa)
AKR02448.1AP-4-A phosphorylase. (195 aa)
AKR02915.1Ribonucleoside-diphosphate reductase subunit beta nrdF2; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (324 aa)
AKR02918.1Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (693 aa)
AKR02939.1Phosphoglucomutase. (547 aa)
AKR03177.1N5-carboxyaminoimidazole ribonucleotide mutase. (174 aa)
purKN5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (429 aa)
AKR03210.1Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (268 aa)
AKR03218.1Adenosine deaminase. (365 aa)
AKR03308.1Nucleoside hydrolase. (308 aa)
guaAGMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP. (525 aa)
AKR03326.1Oxidoreductase. (375 aa)
AKR03327.1Inosine-5'-monophosphate dehydrogenase. (529 aa)
AKR03544.1Hypoxanthine-guanine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (202 aa)
AKR03568.1Transmembrane protein. (549 aa)
Your Current Organism:
Mycobacterium tuberculosis variant bovis
NCBI taxonomy Id: 1765
Other names: ATCC 19210, CIP 105234, M. tuberculosis variant bovis, Mycobacterium bovis, Mycobacterium bovis subsp. bovis, Mycobacterium tuberculosis typus bovinus, Mycobacterium tuberculosis var. bovis, NCTC 10772
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