STRINGSTRING
APZ41854.1 APZ41854.1 rbsK rbsK APZ41713.1 APZ41713.1 proB proB BW247_00270 BW247_00270 thrB thrB gmk gmk APZ41749.1 APZ41749.1 ackA ackA ppk ppk APZ41780.1 APZ41780.1 APZ41781.1 APZ41781.1 BW247_01145 BW247_01145 APZ41878.1 APZ41878.1 APZ41890.1 APZ41890.1 APZ41901.1 APZ41901.1 APZ44475.1 APZ44475.1 APZ41923.1 APZ41923.1 ubiB ubiB APZ41935.1 APZ41935.1 APZ41951.1 APZ41951.1 APZ42073.1 APZ42073.1 APZ44501.1 APZ44501.1 APZ44502.1 APZ44502.1 APZ42120.1 APZ42120.1 APZ42163.1 APZ42163.1 APZ42164.1 APZ42164.1 APZ42186.1 APZ42186.1 pfp pfp APZ42214.1 APZ42214.1 APZ42215.1 APZ42215.1 APZ42221.1 APZ42221.1 nadK nadK APZ42242.1 APZ42242.1 APZ42288.1 APZ42288.1 APZ42303.1 APZ42303.1 APZ42323.1 APZ42323.1 APZ42372.1 APZ42372.1 APZ42405.1 APZ42405.1 APZ42406.1 APZ42406.1 APZ42430.1 APZ42430.1 APZ42489.1 APZ42489.1 APZ42519.1 APZ42519.1 lpxK lpxK APZ42657.1 APZ42657.1 APZ42733.1 APZ42733.1 APZ42749.1 APZ42749.1 hldE hldE APZ44582.1 APZ44582.1 cmk cmk APZ42845.1 APZ42845.1 pfkA pfkA APZ42894.1 APZ42894.1 ispE ispE prs prs APZ42978.1 APZ42978.1 APZ43000.1 APZ43000.1 APZ43012.1 APZ43012.1 BW247_07985 BW247_07985 ndk ndk APZ43198.1 APZ43198.1 pyrH pyrH xylB xylB APZ43284.1 APZ43284.1 ompR ompR APZ43414.1 APZ43414.1 APZ43452.1 APZ43452.1 APZ43495.1 APZ43495.1 glpK glpK cysC cysC APZ43596.1 APZ43596.1 tmk tmk APZ43660.1 APZ43660.1 APZ44690.1 APZ44690.1 argB argB APZ43685.1 APZ43685.1 APZ43690.1 APZ43690.1 coaE coaE coaX coaX APZ43766.1 APZ43766.1 APZ43830.1 APZ43830.1 APZ43938.1 APZ43938.1 APZ43940.1 APZ43940.1 APZ43946.1 APZ43946.1 APZ43956.1 APZ43956.1 APZ44051.1 APZ44051.1 adk adk APZ44125.1 APZ44125.1 anmK anmK APZ44177.1 APZ44177.1 thiL thiL APZ44201.1 APZ44201.1 APZ44215.1 APZ44215.1 APZ44242.1 APZ44242.1 BW247_15100 BW247_15100 APZ44253.1 APZ44253.1 APZ44270.1 APZ44270.1 pgk pgk APZ44288.1 APZ44288.1 aroK aroK APZ44330.1 APZ44330.1 APZ44331.1 APZ44331.1 APZ44365.1 APZ44365.1 APZ44373.1 APZ44373.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APZ41854.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (446 aa)
rbsKRibokinase; Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway. (297 aa)
APZ41713.1Riboflavin biosynthesis protein RibF; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribF family. (315 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (369 aa)
BW247_00270Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (821 aa)
thrBHomoserine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudomonas-type ThrB family. (316 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (204 aa)
APZ41749.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
ppkPolyphosphate kinase 1; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (703 aa)
APZ41780.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (872 aa)
APZ41781.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
BW247_01145Hypothetical protein; Incomplete; partial in the middle of a contig; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (389 aa)
APZ41878.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
APZ41890.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)
APZ41901.1Diacylglycerol kinase; Recycling of diacylglycerol produced during the turnover of membrane phospholipid. (124 aa)
APZ44475.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
APZ41923.1Two-component system sensor histidine kinase NtrB; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
ubiBUbiquinone biosynthesis regulatory protein kinase UbiB; Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis. (561 aa)
APZ41935.1Polyphosphate kinase 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
APZ41951.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (272 aa)
APZ42073.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
APZ44501.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
APZ44502.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
APZ42120.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (812 aa)
APZ42163.1Deoxynucleoside kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
APZ42164.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (165 aa)
APZ42186.1Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (428 aa)
APZ42214.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (724 aa)
APZ42215.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (714 aa)
APZ42221.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (885 aa)
nadKNAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (289 aa)
APZ42242.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (415 aa)
APZ42288.1Hrp-dependent type III effector protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
APZ42303.1PrkA family serine protein kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (640 aa)
APZ42323.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (479 aa)
APZ42372.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
APZ42405.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
APZ42406.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (597 aa)
APZ42430.1Polyphosphate kinase 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
APZ42489.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
APZ42519.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (201 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (329 aa)
APZ42657.1Tetraacyldisaccharide 4'-kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0434 family. (61 aa)
APZ42733.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (226 aa)
APZ42749.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (855 aa)
hldEBifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (480 aa)
APZ44582.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
APZ42845.1Ubiquinol-cytochrome C reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (379 aa)
APZ42894.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
ispE4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (281 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa)
APZ42978.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (700 aa)
APZ43000.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
APZ43012.1Chemotaxis protein CheA; Derived by automated computational analysis using gene prediction method: Protein Homology. (653 aa)
BW247_07985Transposase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (143 aa)
APZ43198.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1000 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (244 aa)
xylBAAA family ATPase; Incomplete; partial in the middle of a contig; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (485 aa)
APZ43284.1Carbohydrate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
ompRPart of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
APZ43414.16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (355 aa)
APZ43452.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (514 aa)
APZ43495.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (510 aa)
glpKGlycerol kinase; Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate; Belongs to the FGGY kinase family. (499 aa)
cysCAdenylyltransferase; Catalyzes the synthesis of activated sulfate. (572 aa)
APZ43596.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (214 aa)
APZ43660.1Phosphoenolpyruvate synthase regulatory protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the phosphoenolpyruvate synthase (PEPS) by catalyzing its phosphorylation/dephosphorylation. (274 aa)
APZ44690.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (293 aa)
APZ43685.1Carbohydrate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the carbohydrate kinase PfkB family. (321 aa)
APZ43690.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (841 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (213 aa)
coaXHypothetical protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (240 aa)
APZ43766.1IS1595 family transposase; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
APZ43830.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
APZ43938.1HPr(Ser) kinase/phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HPrK/P family. (314 aa)
APZ43940.1PTS fructose transporter subunit IIA; Derived by automated computational analysis using gene prediction method: Protein Homology. (135 aa)
APZ43946.1Phosphoenolpyruvate--protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). (581 aa)
APZ43956.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (536 aa)
APZ44051.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (68 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (221 aa)
APZ44125.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial glucokinase family. (344 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (378 aa)
APZ44177.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (326 aa)
APZ44201.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (712 aa)
APZ44215.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (1930 aa)
APZ44242.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the fructosamine kinase family. (293 aa)
BW247_15100Hypothetical protein; Incomplete; partial in the middle of a contig; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (901 aa)
APZ44253.1Phosphoribulokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
APZ44270.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (483 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (392 aa)
APZ44288.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (773 aa)
aroKShikimate kinase I; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (189 aa)
APZ44330.1Urea ABC transporter substrate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
APZ44331.1Hybrid sensor histidine kinase/response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (1137 aa)
APZ44365.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (441 aa)
APZ44373.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (738 aa)
Your Current Organism:
Acidihalobacter ferrooxidans
NCBI taxonomy Id: 1765967
Other names: A. ferrooxidans
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