STRINGSTRING
APZ43710.1 APZ43710.1 gyrB gyrB APZ41700.1 APZ41700.1 APZ41733.1 APZ41733.1 APZ41815.1 APZ41815.1 APZ41834.1 APZ41834.1 hemL hemL dapF dapF pgi pgi groL groL gmhA gmhA APZ42189.1 APZ42189.1 APZ42293.1 APZ42293.1 BW247_03660 BW247_03660 APZ42338.1 APZ42338.1 parE parE parC parC APZ42395.1 APZ42395.1 BW247_04445 BW247_04445 gpmA gpmA APZ44549.1 APZ44549.1 APZ44550.1 APZ44550.1 APZ42638.1 APZ42638.1 APZ42661.1 APZ42661.1 BW247_05855 BW247_05855 BW247_06200 BW247_06200 hldD hldD APZ42768.1 APZ42768.1 mtnA mtnA gyrA gyrA APZ44584.1 APZ44584.1 APZ42879.1 APZ42879.1 APZ42900.1 APZ42900.1 APZ42909.1 APZ42909.1 trpF trpF APZ42972.1 APZ42972.1 queA queA APZ44646.1 APZ44646.1 truA truA truD truD APZ43459.1 APZ43459.1 APZ43461.1 APZ43461.1 APZ44665.1 APZ44665.1 APZ43469.1 APZ43469.1 APZ43485.1 APZ43485.1 APZ43522.1 APZ43522.1 APZ43530.1 APZ43530.1 APZ43532.1 APZ43532.1 nnrD nnrD rpiA rpiA BW247_11195 BW247_11195 tig tig fabA fabA gpmI gpmI hisA hisA apaG apaG APZ43742.1 APZ43742.1 APZ43752.1 APZ43752.1 APZ44702.1 APZ44702.1 truB truB tpiA tpiA glmM glmM APZ43881.1 APZ43881.1 APZ43916.1 APZ43916.1 APZ43931.1 APZ43931.1 murI murI surA surA tal tal APZ44235.1 APZ44235.1 APZ44238.1 APZ44238.1 purE purE APZ44354.1 APZ44354.1 topA topA APZ44409.1 APZ44409.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APZ43710.1Peptidylprolyl isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (161 aa)
gyrBDNA topoisomerase (ATP-hydrolyzing) subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP [...] (800 aa)
APZ41700.1Ribose ABC transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (145 aa)
APZ41733.1Aspartate racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
APZ41815.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (262 aa)
APZ41834.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (230 aa)
hemLGlutamate-1-semialdehyde-2,1-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (285 aa)
pgiGlucose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GPI family. (549 aa)
groLChaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (550 aa)
gmhAPhosphoheptose isomerase; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (194 aa)
APZ42189.13-hydroxyacyl-CoA dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (804 aa)
APZ42293.1Isochorismate-pyruvate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (105 aa)
BW247_03660Transposase; Incomplete; partial in the middle of a contig; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (324 aa)
APZ42338.1Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (171 aa)
parEDNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (628 aa)
parCDNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (746 aa)
APZ42395.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
BW247_04445Hypothetical protein; Incomplete; partial in the middle of a contig; missing start; Derived by automated computational analysis using gene prediction method: Protein Homology. (375 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (245 aa)
APZ44549.1NAD-dependent dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
APZ44550.1Squalene--hopene cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (655 aa)
APZ42638.1Thiol:disulfide interchange protein DsbG; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (253 aa)
APZ42661.123S rRNA pseudouridine(955/2504/2580) synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (320 aa)
BW247_05855Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (543 aa)
BW247_06200IS4 family transposase; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
hldDADP-glyceromanno-heptose 6-epimerase; Catalyzes the interconversion between ADP-D-glycero-beta-D- manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose; Belongs to the NAD(P)-dependent epimerase/dehydratase family. HldD subfamily. (312 aa)
APZ42768.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (366 aa)
mtnAS-methyl-5-thioribose-1-phosphate isomerase; Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). (345 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (855 aa)
APZ44584.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
APZ42879.123S rRNA pseudouridylate synthase B; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (277 aa)
APZ42900.123S rRNA pseudouridine(1911/1915/1917) synthase; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (321 aa)
APZ42909.1dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (182 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (208 aa)
APZ42972.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
queAIntegrase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (344 aa)
APZ44646.1UDP-glucose 4-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (320 aa)
truAIS4 family transposase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (258 aa)
truDtRNA pseudouridine(13) synthase TruD; Responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs; Belongs to the pseudouridine synthase TruD family. (339 aa)
APZ43459.1Thiol:disulfide interchange protein DsbG; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
APZ43461.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (351 aa)
APZ44665.1CDP-glucose 4,6-dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
APZ43469.1dTDP-4-dehydrorhamnose 3,5-epimerase; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (179 aa)
APZ43485.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
APZ43522.1UDP-N-acetylglucosamine 2-epimerase (non-hydrolyzing); Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (368 aa)
APZ43530.1Thiol:disulfide interchange protein DsbG; Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process; Belongs to the thioredoxin family. DsbC subfamily. (190 aa)
APZ43532.1Capsular biosynthesis protein CpsI; Derived by automated computational analysis using gene prediction method: Protein Homology. (335 aa)
nnrDBifunctional ADP-dependent (S)-NAD(P)H-hydrate dehydratase/NAD(P)H-hydrate epimerase; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-spec [...] (486 aa)
rpiARibose 5-phosphate isomerase A; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (218 aa)
BW247_11195Hypothetical protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (631 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (433 aa)
fabA3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabA; Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to E- (2)-decenoyl-ACP and then its isomerization to Z-(3)-decenoyl-ACP. Can catalyze the dehydratase reaction for beta-hydroxyacyl-ACPs with saturated chain lengths up to 16:0, being most active on intermediate chain length. (173 aa)
gpmIPhosphoglycerate mutase (2,3-diphosphoglycerate-independent); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (521 aa)
hisA1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
apaGCo2+/Mg2+ efflux protein ApaG; Derived by automated computational analysis using gene prediction method: Protein Homology. (127 aa)
APZ43742.1Asp/Glu/hydantoin racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
APZ43752.1Asp/Glu/hydantoin racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
APZ44702.1Asp/Glu racemase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
truBtRNA pseudouridine(55) synthase TruB; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (306 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (446 aa)
APZ43881.1Phosphomannomutase/phosphoglucomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (459 aa)
APZ43916.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
APZ43931.1D-arabinose 5-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (279 aa)
surAHypothetical protein; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (436 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (374 aa)
APZ44235.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
APZ44238.1Pseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (200 aa)
purE5-(carboxyamino)imidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (166 aa)
APZ44354.1Peptidylprolyl isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (187 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (821 aa)
APZ44409.1N-acylglucosamine 2-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
Your Current Organism:
Acidihalobacter ferrooxidans
NCBI taxonomy Id: 1765967
Other names: A. ferrooxidans
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