STRINGSTRING
APZ44739.1 APZ44739.1 murJ murJ murE murE APZ41842.1 APZ41842.1 APZ41877.1 APZ41877.1 APZ42034.1 APZ42034.1 mrdB mrdB APZ42062.1 APZ42062.1 APZ42109.1 APZ42109.1 APZ42134.1 APZ42134.1 ftsI ftsI murE-2 murE-2 murF murF mraY mraY murD murD ftsW ftsW murC murC murB murB ddl ddl APZ42238.1 APZ42238.1 APZ42269.1 APZ42269.1 APZ42335.1 APZ42335.1 mltF mltF uppP uppP APZ44319.1 APZ44319.1 APZ42408.1 APZ42408.1 murA murA APZ44559.1 APZ44559.1 APZ42705.1 APZ42705.1 uppP-2 uppP-2 APZ42747.1 APZ42747.1 mpl mpl APZ42953.1 APZ42953.1 APZ43119.1 APZ43119.1 uppS uppS nagZ nagZ APZ43451.1 APZ43451.1 APZ43523.1 APZ43523.1 APZ44678.1 APZ44678.1 anmK anmK mltG mltG glmU glmU APZ44008.1 APZ44008.1 murI murI APZ44114.1 APZ44114.1 rlpA rlpA APZ44116.1 APZ44116.1 rlpA-2 rlpA-2 mrdB-2 mrdB-2 mrdA mrdA APZ44127.1 APZ44127.1 APZ44162.1 APZ44162.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APZ44739.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
murJMurein biosynthesis integral membrane protein MurJ; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (517 aa)
murEHypothetical protein; Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. (483 aa)
APZ41842.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (684 aa)
APZ41877.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (337 aa)
APZ42034.1Penicillin-binding protein 2; Derived by automated computational analysis using gene prediction method: Protein Homology. (689 aa)
mrdBRod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa)
APZ42062.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
APZ42109.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
APZ42134.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (639 aa)
ftsIHypothetical protein; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (573 aa)
murE-2UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (484 aa)
murFHypothetical protein; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (456 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (361 aa)
murDUDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (451 aa)
ftsWPutative lipid II flippase FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (417 aa)
murCUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation; Belongs to the MurCDEF family. (473 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (306 aa)
ddlD-alanine--D-alanine ligase; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (314 aa)
APZ42238.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (277 aa)
APZ42269.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (269 aa)
APZ42335.1Penicillin-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (842 aa)
mltFLytic transglycosylase F; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (497 aa)
uppPIS4 family transposase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (267 aa)
APZ44319.1Peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (850 aa)
APZ42408.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
APZ44559.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
APZ42705.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
uppP-2Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (278 aa)
APZ42747.1N-acetylmuramoyl-L-alanine amidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (459 aa)
APZ42953.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
APZ43119.1Glycoside hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (153 aa)
uppSDi-trans,poly-cis-decaprenylcistransferase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (260 aa)
nagZbeta-N-acetylhexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (348 aa)
APZ43451.1Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (785 aa)
APZ43523.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
APZ44678.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
anmKanhydro-N-acetylmuramic acid kinase; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (378 aa)
mltGHypothetical protein; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (339 aa)
glmUUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (461 aa)
APZ44008.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (279 aa)
APZ44114.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. (398 aa)
rlpAHypothetical protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (249 aa)
APZ44116.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. (401 aa)
rlpA-2Hypothetical protein; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (249 aa)
mrdB-2Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (360 aa)
mrdAPenicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (671 aa)
APZ44127.1Peptidase M15; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the peptidase S11 family. (390 aa)
APZ44162.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (750 aa)
Your Current Organism:
Acidihalobacter ferrooxidans
NCBI taxonomy Id: 1765967
Other names: A. ferrooxidans
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