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APZ42444.1 APZ42444.1 APZ42445.1 APZ42445.1 APZ42449.1 APZ42449.1 APZ42664.1 APZ42664.1 APZ42665.1 APZ42665.1 leuA-2 leuA-2 accD accD APZ43075.1 APZ43075.1 APZ44639.1 APZ44639.1 accA accA APZ43373.1 APZ43373.1 APZ43511.1 APZ43511.1 APZ43580.1 APZ43580.1 APZ44690.1 APZ44690.1 APZ43678.1 APZ43678.1 mdh mdh BW247_12480 BW247_12480 APZ43802.1 APZ43802.1 APZ43803.1 APZ43803.1 APZ43918.1 APZ43918.1 APZ43928.1 APZ43928.1 APZ43976.1 APZ43976.1 APZ44042.1 APZ44042.1 APZ44043.1 APZ44043.1 APZ44150.1 APZ44150.1 APZ44206.1 APZ44206.1 APZ44209.1 APZ44209.1 APZ44270.1 APZ44270.1 APZ44342.1 APZ44342.1 APZ44386.1 APZ44386.1 ackA ackA APZ41766.1 APZ41766.1 APZ41767.1 APZ41767.1 APZ41857.1 APZ41857.1 APZ42002.1 APZ42002.1 APZ42011.1 APZ42011.1 leuA leuA ppc ppc APZ42125.1 APZ42125.1 APZ42131.1 APZ42131.1 APZ42173.1 APZ42173.1 APZ42190.1 APZ42190.1 acsA acsA APZ42323.1 APZ42323.1 aspA aspA APZ42424.1 APZ42424.1 APZ42440.1 APZ42440.1 APZ42443.1 APZ42443.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APZ42444.1Alpha-ketoacid dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (332 aa)
APZ42445.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
APZ42449.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
APZ42664.1Oxaloacetate decarboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (606 aa)
APZ42665.1acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (472 aa)
leuA-22-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (564 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (292 aa)
APZ43075.1MBL fold metallo-hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
APZ44639.1Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
APZ43373.1NADP-dependent malic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (780 aa)
APZ43511.1MBL fold hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
APZ43580.1Pyruvate oxidase; Catalyzes the formation of acetate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (571 aa)
APZ44690.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa)
APZ43678.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (307 aa)
BW247_12480Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
APZ43802.1Dihydrolipoyllysine-residue acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (432 aa)
APZ43803.1Pyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (887 aa)
APZ43918.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (91 aa)
APZ43928.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
APZ43976.1Lactoylglutathione lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
APZ44042.1acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (149 aa)
APZ44043.1acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (446 aa)
APZ44150.1Iron permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
APZ44206.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
APZ44209.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (467 aa)
APZ44270.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (483 aa)
APZ44342.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
APZ44386.1Type 1 glutamine amidotransferase domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
APZ41766.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (694 aa)
APZ41767.1GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (896 aa)
APZ41857.1Peroxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
APZ42002.1Glyoxalase/bleomycin resistance/dioxygenase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
APZ42011.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (515 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (940 aa)
APZ42125.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
APZ42131.1FAD-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
APZ42173.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (156 aa)
APZ42190.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (394 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (653 aa)
APZ42323.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pyruvate kinase family. (479 aa)
aspAAspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (468 aa)
APZ42424.1MBL fold metallo-hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
APZ42440.1Phosphate acetyl/butaryl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
APZ42443.1Dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (416 aa)
Your Current Organism:
Acidihalobacter ferrooxidans
NCBI taxonomy Id: 1765967
Other names: A. ferrooxidans
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