STRINGSTRING
APZ41766.1 APZ41766.1 ackA ackA glyA glyA ppc ppc fbp fbp pfp pfp acsA acsA eno eno APZ42351.1 APZ42351.1 APZ42384.1 APZ42384.1 APZ42386.1 APZ42386.1 APZ42438.1 APZ42438.1 APZ42440.1 APZ42440.1 gpmA gpmA serC serC APZ42807.1 APZ42807.1 pfkA pfkA APZ43090.1 APZ43090.1 APZ43091.1 APZ43091.1 gfa gfa APZ43096.1 APZ43096.1 APZ43097.1 APZ43097.1 APZ43098.1 APZ43098.1 APZ43099.1 APZ43099.1 APZ43252.1 APZ43252.1 APZ44639.1 APZ44639.1 eno-2 eno-2 APZ43367.1 APZ43367.1 APZ43368.1 APZ43368.1 APZ43370.1 APZ43370.1 APZ43371.1 APZ43371.1 APZ44651.1 APZ44651.1 APZ43414.1 APZ43414.1 APZ43462.1 APZ43462.1 APZ43579.1 APZ43579.1 APZ43596.1 APZ43596.1 gpmI gpmI APZ44690.1 APZ44690.1 APZ44269.1 APZ44269.1 APZ44411.1 APZ44411.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APZ41766.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (694 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (418 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (940 aa)
fbpFructose-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (336 aa)
pfp6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (428 aa)
acsAacetate--CoA ligase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (653 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (432 aa)
APZ42351.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (133 aa)
APZ42384.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
APZ42386.1Haloacid dehalogenase-like hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (310 aa)
APZ42438.1Aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)
APZ42440.1Phosphate acetyl/butaryl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (245 aa)
serCPhosphoserine transaminase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine; Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. (360 aa)
APZ42807.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (387 aa)
pfkA6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily. (379 aa)
APZ43090.1S-formylglutathione hydrolase; Serine hydrolase involved in the detoxification of formaldehyde. (282 aa)
APZ43091.1S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa)
gfaS-(hydroxymethyl)glutathione synthase; Catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione; Belongs to the Gfa family. (193 aa)
APZ43096.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
APZ43097.1Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
APZ43098.1Formate dehydrogenase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (951 aa)
APZ43099.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (80 aa)
APZ43252.1Alanine--glyoxylate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
APZ44639.1Acetaldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
eno-2Phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (425 aa)
APZ43367.1Disulfide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (303 aa)
APZ43368.1Heterodisulfide reductase subunit C; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
APZ43370.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (349 aa)
APZ43371.1Heterodisulfide reductase subunit B; Derived by automated computational analysis using gene prediction method: Protein Homology. (450 aa)
APZ44651.1Heterodisulfide reductase subunit C; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
APZ43414.16-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. (355 aa)
APZ43462.1Glycerate dehydrogenase; Catalyzes the reduction of hydroxypyruvate to form D-glycerate, using NADH as an electron donor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (318 aa)
APZ43579.1FMN-binding glutamate synthase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (563 aa)
APZ43596.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
gpmIPhosphoglycerate mutase (2,3-diphosphoglycerate-independent); Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (521 aa)
APZ44690.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (792 aa)
APZ44269.1Fructose-1,6-bisphosphate aldolase; Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. (354 aa)
APZ44411.1Aldehyde-activating protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
Your Current Organism:
Acidihalobacter ferrooxidans
NCBI taxonomy Id: 1765967
Other names: A. ferrooxidans
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