(22 nodes) (2019) Integrated transcriptomic and proteomic analysis of pathogenic mycobacteria and their esx-1 mutants reveal secretion-dependent regulation of ESX-1 substrates and WhiB6 as a transcriptional regulator. network (Mycobacterium kansasii)

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Predicted Interactions

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protein homology

Your Input:
	groS	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (100 aa)
	ARG95965.1	Error-prone DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA polymerase type-C family. DnaE2 subfamily. (1100 aa)
	ftsE	Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division. (229 aa)
	ARG95123.1	DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1183 aa)
	cpsY	Sugar phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (532 aa)
	lysA	Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (468 aa)
	ftsW	Putative lipid II flippase FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family. (576 aa)
	ARG90828.1	Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (766 aa)
	lsr2	Lsr2 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
	hflB	Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (746 aa)
	espC	ESX-1 secretion-associated protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
	espA	Secretion protein EspA; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
	espR	Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
	esxB	WXG100 family type VII secretion target; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the WXG100 family. (100 aa)
	esat6	WXG100 family type VII secretion target; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the WXG100 family. (95 aa)
	eccE1	Type VII secretion protein EccE; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
	pckG	Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (607 aa)
	dnaK	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (621 aa)
	grpE	Nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...] (221 aa)
	ARG93579.1	Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
	ahpC	Alkyl hydroperoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
	ahpD	Alkyl hydroperoxide reductase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity. (178 aa)

Your Current Organism:

Mycobacterium kansasii

NCBI taxonomy Id: 1768
Other names: ATCC 12478, CIP 104589, DSM 44162, JCM 6379, M. kansasii, NCTC 13024

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ARG90828.1	ARG93579.1	B1T50_00900	B1T50_18305	Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.919
ARG90828.1	pckG	B1T50_00900	B1T50_16575	Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.	0.579
ARG93579.1	ARG90828.1	B1T50_18305	B1T50_00900	Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.919
ARG93579.1	pckG	B1T50_18305	B1T50_16575	Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Phosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.	0.707
ARG95123.1	ahpD	B1T50_27830	B1T50_00610	DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Alkyl hydroperoxide reductase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.	0.440
ARG95123.1	ftsW	B1T50_27830	B1T50_02575	DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	Putative lipid II flippase FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family.	0.517
ARG95965.1	ahpD	B1T50_20500	B1T50_00610	Error-prone DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA polymerase type-C family. DnaE2 subfamily.	Alkyl hydroperoxide reductase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.	0.442
ahpC	ahpD	B1T50_00615	B1T50_00610	Alkyl hydroperoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Alkyl hydroperoxide reductase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.	0.990
ahpC	dnaK	B1T50_00615	B1T50_17525	Alkyl hydroperoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.494
ahpC	groS	B1T50_00615	B1T50_20235	Alkyl hydroperoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.442
ahpC	grpE	B1T50_00615	B1T50_17530	Alkyl hydroperoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Nucleotide exchange factor GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds [...]	0.548
ahpD	ARG95123.1	B1T50_00610	B1T50_27830	Alkyl hydroperoxide reductase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.	DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.440
ahpD	ARG95965.1	B1T50_00610	B1T50_20500	Alkyl hydroperoxide reductase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.	Error-prone DNA polymerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DNA polymerase type-C family. DnaE2 subfamily.	0.442
ahpD	ahpC	B1T50_00610	B1T50_00615	Alkyl hydroperoxide reductase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.	Alkyl hydroperoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.990
ahpD	groS	B1T50_00610	B1T50_20235	Alkyl hydroperoxide reductase; Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.468
cpsY	ftsE	B1T50_10995	B1T50_22550	Sugar phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cell division ATP-binding protein FtsE; Part of the ABC transporter FtsEX involved in cellular division.	0.531
cpsY	ftsW	B1T50_10995	B1T50_02575	Sugar phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Putative lipid II flippase FtsW; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SEDS family.	0.494
cpsY	hflB	B1T50_10995	B1T50_12500	Sugar phosphotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Cell division protein FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family.	0.537
dnaK	ahpC	B1T50_17525	B1T50_00615	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Alkyl hydroperoxide reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.494
dnaK	groS	B1T50_17525	B1T50_20235	Molecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.	Molecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.953