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cbiC cbiC cbiA1 cbiA1 cbiD cbiD cobU cobU cobQ cobQ cobO cobO cobJ cobJ cbiG cbiG cobM cobM cobL cobL cbiL cbiL cobT1 cobT1 cbiK1 cbiK1 cbiK2 cbiK2 hemA hemA ccmC1 ccmC1 cysG cysG cobT2 cobT2 resB resB ccmC2 ccmC2 hemL hemL hemB hemB hemC hemC hemD hemD cbiA2 cbiA2 ACN17404.1 ACN17404.1 cbiB cbiB ACN17622.1 ACN17622.1 cobS cobS cbiK3 cbiK3
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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experimentally determined
Predicted Interactions
gene neighborhood
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cbiCCbiC; Cobalamin (vitamin B12) biosynthesis protein CbiC (precorrin-8X methylmutase). (204 aa)
cbiA1CbiA1; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (486 aa)
cbiDCbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (368 aa)
cobUCobU; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (176 aa)
cobQCobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (500 aa)
cobOCobO; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (171 aa)
cobJCobJ; precorrin-3B C17-methyltransferase CobJ (Precorrin-3 methyltransferase) (Precorrin-3 methylase). (294 aa)
cbiGCbiG; Cobalamin biosynthesis protein CbiG. (393 aa)
cobMCobM; Precorrin-4 C11-methyltransferase CobM. (260 aa)
cobLCobL; Decarboxylating precorrin-6Y C5,15-methyltransferase CobL (Precorrin-6 methyltransferase) (Precorrin-6Y methylase). (418 aa)
cbiLCbiL; Precorrin-2 C20-methyltransferase CbiL (S-adenosyl-L- methionine--precorrin-2 methyltransferase); Belongs to the precorrin methyltransferase family. (235 aa)
cobT1CobT1; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (353 aa)
cbiK1CbiK1; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. (318 aa)
cbiK2CbiK2; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. (259 aa)
hemAHemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (428 aa)
ccmC1CcmC1; Cytochrome c assembly protein CcmC. (259 aa)
cysGCysG; Siroheme synthase (uroporphyrin-III C-methyltransferase; precorrin-2 dehydrogenase; sirohydrochlorin ferrochelatase). (221 aa)
cobT2CobT2; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (701 aa)
resBResB; Transmembrane cytochrome c biogenesis protein ResB. (459 aa)
ccmC2CcmC2; Cytochrome c assembly protein CcmC. (277 aa)
hemLHemL; Glutamate-1-semialdehyde 2,1-aminomutase HemL. (428 aa)
hemBHemB; Delta-aminolevulinic acid dehydratase HemB (porphobilinogensynthase); Belongs to the ALAD family. (327 aa)
hemCHemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (325 aa)
hemDHemD; Porphyrin biosynthesis protein HemD [includes: uroporphyrin-III C-methyltransferase; uroporphyrinogen-III synthase]. (513 aa)
cbiA2CbiA2; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (481 aa)
ACN17404.1Hypothetical protein. (364 aa)
cbiBCbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (317 aa)
ACN17622.1Putative histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (371 aa)
cobSCobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (253 aa)
cbiK3CbiK3; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. (255 aa)
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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