STRINGSTRING
cbiD cbiD cobQ cobQ cobO cobO cbiK1 cbiK1 cbiK2 cbiK2 ACN13945.1 ACN13945.1 hemA hemA cysG cysG hemE hemE ACN14550.1 ACN14550.1 ACN14644.1 ACN14644.1 cobT2 cobT2 hemL hemL nirD nirD hemB hemB ACN16037.1 ACN16037.1 ACN16064.1 ACN16064.1 hemN2 hemN2 hemC hemC hemD hemD ACN16952.1 ACN16952.1 cbiA2 cbiA2 ACN17354.1 ACN17354.1 ACN17404.1 ACN17404.1 cbiB cbiB ACN17622.1 ACN17622.1 cobS cobS cbiK3 cbiK3 ACN17778.1 ACN17778.1 uroD uroD ACN17994.1 ACN17994.1 cobU cobU cbiG cbiG cobJ cobJ cbiC cbiC cbiA1 cbiA1 cobM cobM cobL cobL cbiL cbiL ACN13631.1 ACN13631.1 cobT1 cobT1 thiC thiC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
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cbiDCbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (368 aa)
cobQCobQ; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (500 aa)
cobOCobO; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (171 aa)
cbiK1CbiK1; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. (318 aa)
cbiK2CbiK2; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. (259 aa)
ACN13945.1Predicted serine/threonine protein kinase PpkA. (727 aa)
hemAHemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (428 aa)
cysGCysG; Siroheme synthase (uroporphyrin-III C-methyltransferase; precorrin-2 dehydrogenase; sirohydrochlorin ferrochelatase). (221 aa)
hemEHemE; Uroporphyrinogen decarboxylase HemE (URO-D); Belongs to the uroporphyrinogen decarboxylase family. (358 aa)
ACN14550.1Hypothetical protein. (165 aa)
ACN14644.1Hypothetical protein. (181 aa)
cobT2CobT2; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (701 aa)
hemLHemL; Glutamate-1-semialdehyde 2,1-aminomutase HemL. (428 aa)
nirDNirD; Heme d1 biosynthesis protein NirD [precursor]. (151 aa)
hemBHemB; Delta-aminolevulinic acid dehydratase HemB (porphobilinogensynthase); Belongs to the ALAD family. (327 aa)
ACN16037.1Conserved hypothetical protein. (332 aa)
ACN16064.1Putative flavin-containing amine oxidoreductase family protein. (464 aa)
hemN2HemN2; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (382 aa)
hemCHemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (325 aa)
hemDHemD; Porphyrin biosynthesis protein HemD [includes: uroporphyrin-III C-methyltransferase; uroporphyrinogen-III synthase]. (513 aa)
ACN16952.1Putative uroporphyrinogen-III decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. (314 aa)
cbiA2CbiA2; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (481 aa)
ACN17354.1Putative ABC-type transport system, hydrolase component. (372 aa)
ACN17404.1Hypothetical protein. (364 aa)
cbiBCbiB; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (317 aa)
ACN17622.1Putative histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase. (371 aa)
cobSCobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (253 aa)
cbiK3CbiK3; Catalyzes the insertion of Co(2+) into sirohydrochlorin. Belongs to the CbiK family. (255 aa)
ACN17778.1Conserved hypothetical protein. (225 aa)
uroDUroD; Uroporphyrinogen decarboxylase UroD; Belongs to the uroporphyrinogen decarboxylase family. (452 aa)
ACN17994.1Conserved hypothetical protein. (140 aa)
cobUCobU; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (176 aa)
cbiGCbiG; Cobalamin biosynthesis protein CbiG. (393 aa)
cobJCobJ; precorrin-3B C17-methyltransferase CobJ (Precorrin-3 methyltransferase) (Precorrin-3 methylase). (294 aa)
cbiCCbiC; Cobalamin (vitamin B12) biosynthesis protein CbiC (precorrin-8X methylmutase). (204 aa)
cbiA1CbiA1; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (486 aa)
cobMCobM; Precorrin-4 C11-methyltransferase CobM. (260 aa)
cobLCobL; Decarboxylating precorrin-6Y C5,15-methyltransferase CobL (Precorrin-6 methyltransferase) (Precorrin-6Y methylase). (418 aa)
cbiLCbiL; Precorrin-2 C20-methyltransferase CbiL (S-adenosyl-L- methionine--precorrin-2 methyltransferase); Belongs to the precorrin methyltransferase family. (235 aa)
ACN13631.1Putative HTH-type transcriptional regulator. (155 aa)
cobT1CobT1; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (353 aa)
thiCThiC; Catalyzes the conversion of aminoimidazole ribotide (AIR) to 5-hydroxybenzimidazole (5-HBI) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Is thus involved in the anaerobic biosynthesis of the benzimidazole lower axial ligand of the cobamide produced by D.autotrophicum; Belongs to the ThiC family. 5-hydroxybenzimidazole synthase subfamily. (439 aa)
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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