STRINGSTRING
fur fur ACN13135.1 ACN13135.1 metH1 metH1 ACN13176.1 ACN13176.1 fdx1 fdx1 ACN13246.1 ACN13246.1 speB speB ACN13267.1 ACN13267.1 bioB1 bioB1 ACN13288.1 ACN13288.1 dksA1 dksA1 hisD1 hisD1 fdhE1 fdhE1 ACN13468.1 ACN13468.1 ACN13487.1 ACN13487.1 ACN13512.1 ACN13512.1 clpX1 clpX1 ACN13572.1 ACN13572.1 ACN13600.1 ACN13600.1 ftsH ftsH priA priA rbr1 rbr1 ACN13734.1 ACN13734.1 mop1 mop1 dksA2 dksA2 metH2 metH2 ACN13897.1 ACN13897.1 fba2 fba2 ACN13979.1 ACN13979.1 galT galT hisI hisI dksA3 dksA3 ACN14269.1 ACN14269.1 hypC hypC hypF hypF hysA hysA mvhA mvhA gloB gloB ACN14327.1 ACN14327.1 ispG ispG ACN14395.1 ACN14395.1 appA appA tsaD tsaD fucA fucA ACN14530.1 ACN14530.1 ACN14531.1 ACN14531.1 ACN14564.1 ACN14564.1 fdx6 fdx6 bioB2 bioB2 metH3 metH3 cdhE cdhE ACN14782.1 ACN14782.1 rnj rnj tadA tadA ACN14862.1 ACN14862.1 ACN14895.1 ACN14895.1 ACN14903.1 ACN14903.1 pdxA pdxA cysS1 cysS1 dnaJ3 dnaJ3 dppA2 dppA2 ACN15259.1 ACN15259.1 htpX htpX hynA hynA cysS2 cysS2 pepN pepN ileS ileS hydA2 hydA2 ACN15798.1 ACN15798.1 alaS1 alaS1 ACN15828.1 ACN15828.1 pepT pepT pyrC pyrC clpX2 clpX2 ribB ribB ACN15942.1 ACN15942.1 dppE dppE ACN15973.1 ACN15973.1 rbr3 rbr3 dnaG9 dnaG9 ACN16115.1 ACN16115.1 ftn ftn rnhB rnhB nrdR nrdR ACN16212.1 ACN16212.1 gltX gltX hypB hypB hypA hypA ACN16243.1 ACN16243.1 gpmA2 gpmA2 dksA4 dksA4 fbiC1 fbiC1 fbiC2 fbiC2 ACN16408.1 ACN16408.1 ACN16468.1 ACN16468.1 nfo nfo ACN16539.1 ACN16539.1 metE metE alkA alkA ACN16634.1 ACN16634.1 ybeY ybeY gmhA gmhA rpsN rpsN rpoC rpoC ACN16829.1 ACN16829.1 ACN16838.1 ACN16838.1 coxL coxL mop2 mop2 hyfG hyfG hyfI hyfI ACN17015.1 ACN17015.1 ligB ligB pepA pepA alaS2 alaS2 ACN17126.1 ACN17126.1 hbr1 hbr1 hbr2 hbr2 ACN17169.1 ACN17169.1 pckG pckG ACN17252.1 ACN17252.1 hbr3 hbr3 dfx dfx rbr4 rbr4 ACN17317.1 ACN17317.1 feoA feoA ACN17330.1 ACN17330.1 ecaB ecaB hutI hutI ACN17444.1 ACN17444.1 dppA3 dppA3 hisD2 hisD2 metH4 metH4 ACN17669.1 ACN17669.1 ACN17676.1 ACN17676.1 ACN17727.1 ACN17727.1 ACN17740.1 ACN17740.1 ACN17758.1 ACN17758.1 fdhE2 fdhE2 nudC nudC ACN17912.1 ACN17912.1 ACN17914.1 ACN17914.1 argE argE dppA4 dppA4 porA4 porA4 ACN14238.1 ACN14238.1 ACN14239.1 ACN14239.1 dnaJ2 dnaJ2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
furFur; Ferric uptake regulation protein; Belongs to the Fur family. (328 aa)
ACN13135.1SWI/SNF helicase family protein. (1392 aa)
metH1MetH1; vitamin-B12 dependent methionine synthase MetH (5-methyltetrahydrofolate--homocysteine methyltransferase). (266 aa)
ACN13176.1Conserved hypothetical protein. (55 aa)
fdx1Fdx1; 4Fe-4S ferredoxin, iron-sulfur binding family protein Fdx1. (71 aa)
ACN13246.1Putative methionine synthase I metH2. (99 aa)
speBSpeB; Agmatinase SpeB (agmatine ureohydrolase) (AUH); Belongs to the arginase family. (289 aa)
ACN13267.1Predicted Zn-dependent protease HtpX-like protein. (295 aa)
bioB1BioB1; Biothin synthethase BioB. (348 aa)
ACN13288.1Hypothetical protein. (364 aa)
dksA1DksA1; DnaK suppressor protein DksA. (177 aa)
hisD1HisD1; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (436 aa)
fdhE1FdhE1; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (303 aa)
ACN13468.1Formylmethanofuran dehydrogenase/molybdopterin biosynthesis fusion protein. (563 aa)
ACN13487.1Hypothetical protein. (196 aa)
ACN13512.1Conserved hypothetical protein. (162 aa)
clpX1ClpX1; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (418 aa)
ACN13572.1Putative cytidine/deoxycytidylate deaminase. (181 aa)
ACN13600.1Hypothetical protein. (189 aa)
ftsHFtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (670 aa)
priAPriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (815 aa)
rbr1Rbr1; Rubrerythrin (RR). (191 aa)
ACN13734.1Hypothetical ferredoxin-like protein. (64 aa)
mop1Mop1; Aldehyde oxidoreductase Mop. (905 aa)
dksA2DksA2; DnaK suppressor protein DksA. (114 aa)
metH2MetH2; vitamin-B12 dependent methionine synthase MetH (5-methyltetrahydrofolate--homocysteine methyltransferase). (266 aa)
ACN13897.1NADPH-dependent FMN reductase. (495 aa)
fba2Fba2; Fructose-bisphosphate aldolase Fba. (326 aa)
ACN13979.1Zn-dependent dehydrogenase. (578 aa)
galTGalT; Galactose-1-phosphate uridylyltransferase (Gal-1-P uridylyltransferase) (UDP-glucose--hexose-1-phosphate uridylyltransferase). (357 aa)
hisIHisI; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (125 aa)
dksA3DksA3; DnaK suppressor protein DksA. (120 aa)
ACN14269.1HesB-like domain protein. (103 aa)
hypCHypC; Hydrogenase expression/formation protein HypC. (78 aa)
hypFHypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (733 aa)
hysAHysA; Periplasmic [NiFeSe] hydrogenase, large subunit precursor HysA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (504 aa)
mvhAMvhA; F420-non-reducing hydrogenase, iron-sulfur subunit mvhA. (449 aa)
gloBGloB; Zn-dependent hydroxyacylglutathione hydrolase GloB; Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. (233 aa)
ACN14327.1Peptidase family protein (putative zinc metallopeptidase). (368 aa)
ispGIspG; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (386 aa)
ACN14395.1Conserved hypothetical protein. (341 aa)
appAAppA; ABC-type oligopeptide transport system, substrate binding protein AppA. (514 aa)
tsaDMetalloendopeptidase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (333 aa)
fucAFucA; L-fuculose phosphate aldolase. (226 aa)
ACN14530.1Hypothetical protein. (215 aa)
ACN14531.1Zinc-containing dehydrogenase family protein. (344 aa)
ACN14564.1Hypothetical protein. (248 aa)
fdx6Fdx6; 4Fe-4S ferredoxin, iron-sulfur binding family protein Fdx6. (71 aa)
bioB2BioB2; Biotin synthetase (Biotin synthetase). (355 aa)
metH3MetH3; vitamin-B12 dependent methionine synthase MetH (5-methyltetrahydrofolate--homocysteine methyltransferase). (301 aa)
cdhECdhE; Bifunctional acetyl-CoA synthetase/carbon monoxide dehydrogenase, gamma subunit CdhE. (446 aa)
ACN14782.1Predicted iron-sulfur cluster assembly protein (NifU like protein). (149 aa)
rnjHydrolase (metallo-beta-lactamase superfamily); An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (549 aa)
tadAPutative riboflavin biosynthesis protein ribD; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (150 aa)
ACN14862.1Putative nitrogen fixation protein NifU (NifU-like protein). (151 aa)
ACN14895.1Hypothetical protein. (433 aa)
ACN14903.1Hypothetical protein. (66 aa)
pdxAPdxA; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (340 aa)
cysS1CysS1; Bifunctional cysteinyl-tRNA synthetase CysS1 (Cysteine--tRNA ligase) (CysRS); Belongs to the class-I aminoacyl-tRNA synthetase family. (668 aa)
dnaJ3DnaJ3; Chaperone protein DnaJ. (261 aa)
dppA2DppA2; ABC-type oliopeptide/dipeptide transporter, periplasmic binding protein DppA. (506 aa)
ACN15259.1Putative nitrogen fixation protein NifU (NifU-like protein). (139 aa)
htpXPeptidase (M48 family protein); Belongs to the peptidase M48B family. (309 aa)
hynAHynA; Periplasmic [NiFe] hydrogenase, large subunit HynA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (545 aa)
cysS2CysS2; cysteinyl-tRNA synthetase CysS2 (Cysteine--tRNA ligase) (CysRS); Belongs to the class-I aminoacyl-tRNA synthetase family. (477 aa)
pepNPepN; Aminopeptidase PepN (Alpha-aminoacylpeptide hydrolase). (874 aa)
ileSIleS; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (936 aa)
hydA2HydA2; Fe-only fusion hydrogenase HydA2 (fusion protein consisting of small subunit HydA, large subunit HydB and 4Fe-4S domain). (599 aa)
ACN15798.1Conserved hypothetical protein. (213 aa)
alaS1AlaS1; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (872 aa)
ACN15828.1Conserved hypothetical protein; Belongs to the LarC family. (400 aa)
pepTPeptidase T, tripeptide aminopeptidase PepT (Aminotripeptidase) (Tripeptidase). (379 aa)
pyrCPyrC; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (426 aa)
clpX2ClpX2; ATP-dependent Clp protease, ATP-binding subunit ClpX; Belongs to the ClpX chaperone family. (580 aa)
ribBRibB; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate. (217 aa)
ACN15942.1Conserved hypothetical protein. (272 aa)
dppEDppE; ABC-type dipeptide/oligopeptide/nickel transport system, periplasmic binding protein DppE. (628 aa)
ACN15973.1Putative CO dehydrogenase/acetyl-CoA synthase (Fe-S cluster family protein). (270 aa)
rbr3Rbr3; Rubrerythrin (Rubredoxin-type Fe(Cys)4 protein). (166 aa)
dnaG9DnaG9; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (602 aa)
ACN16115.1Putative peptidase M18 family protein. (475 aa)
ftnFtn; Iron-storage protein. (212 aa)
rnhBRnhB; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. (197 aa)
nrdRConserved hypothetical protein; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (165 aa)
ACN16212.1Conserved hypothetical protein. (167 aa)
gltXGltX; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (463 aa)
hypBHypB; Hydrogenase isoenzymes nickel incorporation protein HypB. (220 aa)
hypAHypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (115 aa)
ACN16243.1Putative aspartyl aminopeptidase. (454 aa)
gpmA2GpmA2; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (511 aa)
dksA4DksA4; DnaK suppressor protein DksA. (88 aa)
fbiC1FbiC1; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (376 aa)
fbiC2FbiC2; FO synthase FbiC (7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase). (85 aa)
ACN16408.1Putative Fe-S oxidoreductase family protein. (565 aa)
ACN16468.1Putative reprotein translocase SecA. (312 aa)
nfoNfo; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (279 aa)
ACN16539.1Hypothetical protein. (210 aa)
metEMetE; 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase MetE (Cobalamin-independent methionine synthase). (368 aa)
alkAAlkA; 3-methyladenine DNA glycosylase AlkA (3-methyladenine-DNA glycosidase). (353 aa)
ACN16634.1Putative ketose-bisphosphate aldolase family protein. (430 aa)
ybeYConserved hypothetical protein; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (155 aa)
gmhAGmhA; Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate. (189 aa)
rpsNRpsN; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (77 aa)
rpoCRpoC; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1385 aa)
ACN16829.1Hypothetical protein. (386 aa)
ACN16838.1Conserved hypothetical protein. (354 aa)
coxLCoxL; Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL. (769 aa)
mop2Mop2; Aldehyde oxidoreductase Mop. (918 aa)
hyfGHyfG; Hydrogenase HyfG homolog, large subunit. (503 aa)
hyfIHyfI; Hydrogenase HyfI homolog, small subunit. (258 aa)
ACN17015.1Ferredoxin (Fe-4S iron-sulfur cluster binding protein). (82 aa)
ligBLigB; Aromatic ring-opening dioxygenase, catalytic subunit LigB. (267 aa)
pepAPepA; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides. (515 aa)
alaS2AlaS2; alanyl-tRNA synthetase AlaS (Alanine--tRNA ligase) (AlaRS). (145 aa)
ACN17126.1Ferredoxin (4Fe-4S iron-sulfur cluster binding protein). (85 aa)
hbr1Hbr1; High molecular weight rubredoxin (Rubredoxin-type Fe(Cys)4 protein. (53 aa)
hbr2Hbr2; High molecular weight rubredoxin (Rubredoxin-type Fe(Cys)4 protein. (198 aa)
ACN17169.1Predicted iron-sulfur cluster assembly protein (NifU like protein). (187 aa)
pckGPckG; Phosphoenolpyruvate carboxykinase PckG (PEP carboxykinase). (638 aa)
ACN17252.1Hypothetical protein. (71 aa)
hbr3Hbr3; High molecular weight rubredoxin (Rubredoxin-type Fe(Cys)4 protein. (52 aa)
dfxDfx; Non-heme iron protein Dfx (desulfoferrodoxin) (Superoxide dismutase). (124 aa)
rbr4Rbr4; Rubrerythrin family protein. (192 aa)
ACN17317.1Conserved hypothetical protein. (539 aa)
feoAFeoA; Ferrous iron (Fe2+) transport protein FeoA. (77 aa)
ACN17330.1TroR; Iron-dependent transcription repressor protein TroR. (138 aa)
ecaBEcaB; Carbonic anhydrase EcaB (Carbonate dehydratase). (318 aa)
hutIHutI; Imidazolonepropionase HutI. (416 aa)
ACN17444.1Homocysteine S-methyltransferase. (303 aa)
dppA3DppA3; Periplasmic dipeptide transport protein DppA. (533 aa)
hisD2HisD2; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (432 aa)
metH4MetH4; vitamin-B12 dependent methionine synthase MetH (5-methyltetrahydrofolate--homocysteine methyltransferase). (209 aa)
ACN17669.1Putative formylmethanofuran dehydrogenase, subunit E. (179 aa)
ACN17676.1Putative uridylate kinase. (282 aa)
ACN17727.1Putative Fe-S cluster. (272 aa)
ACN17740.1Putative Zinc metalloprotease. (160 aa)
ACN17758.1Putative helicase. (942 aa)
fdhE2FdhE2; Necessary for formate dehydrogenase activity. Belongs to the FdhE family. (309 aa)
nudCNudC; NADH pyrophosphatase NudC; Belongs to the Nudix hydrolase family. NudC subfamily. (267 aa)
ACN17912.1Hypothetical protein. (89 aa)
ACN17914.1Putative galactose-1-phosphate uridylyltransferase. (345 aa)
argEArgE; Predicted acetylornithine deacetylase ArgE. (376 aa)
dppA4DppA4; ABC-type peptide transporter, periplasmic peptide-binding protein DppA. (517 aa)
porA4PorA4; Pyruvate:ferredoxin oxidoreductase, subunit PorA4. (1167 aa)
ACN14238.1Conserved hypothetical protein. (354 aa)
ACN14239.1SNF2-related helicase. (903 aa)
dnaJ2DnaJ2; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are [...] (366 aa)
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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