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cbiA1 cbiA1 carB2 carB2 cobS cobS leuC2 leuC2 cbiA2 cbiA2 selA selA hypA hypA hypB hypB sufC sufC guaB guaB zupT zupT comF comF leuC1 leuC1 cdhC cdhC mvhG mvhG hypD hypD hypF hypF hemA hemA leuB leuB fdhD fdhD cbiL cbiL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
cbiA1CbiA1; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (486 aa)
carB2CarB2; Carbamoyl-phosphate synthase, large subunit CarB2; Belongs to the CarB family. (1074 aa)
cobSCobS; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (253 aa)
leuC2LeuC2; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (469 aa)
cbiA2CbiA2; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (481 aa)
selASelA; Converts seryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis. (470 aa)
hypAHypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. (115 aa)
hypBHypB; Hydrogenase isoenzymes nickel incorporation protein HypB. (220 aa)
sufCSufC; FeS assembly ATPase SufC. (251 aa)
guaBGuaB; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (491 aa)
zupTZupT; Heavy-metal cation transporter ZupT. (271 aa)
comFComF; Competence protein F (Phosphoribosyltransferase family protein). (291 aa)
leuC1LeuC1; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (437 aa)
cdhCCdhC; Bifunctional acetyl-CoA synthetase/carbon monoxide dehydrogenase, beta subunit CdhC. (737 aa)
mvhGMvhG; F420-non-reducing hydrogenase, iron-sulfur subunit mvhG. (313 aa)
hypDHypD; Hydrogenase expression/formation protein HypD; Belongs to the HypD family. (362 aa)
hypFHypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (733 aa)
hemAHemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (428 aa)
leuBLeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (358 aa)
fdhDFdhD; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (274 aa)
cbiLCbiL; Precorrin-2 C20-methyltransferase CbiL (S-adenosyl-L- methionine--precorrin-2 methyltransferase); Belongs to the precorrin methyltransferase family. (235 aa)
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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