STRINGSTRING
rndA rndA rndB rndB narI narI narJ narJ narH narH narG narG ACN13249.1 ACN13249.1 pstS1 pstS1 phoA phoA ACN13363.1 ACN13363.1 ACN13364.1 ACN13364.1 pstS3 pstS3 ACN13407.1 ACN13407.1 dctQ1 dctQ1 ACN13480.1 ACN13480.1 ACN13690.1 ACN13690.1 ACN13694.1 ACN13694.1 ACN13731.1 ACN13731.1 glnA1 glnA1 glnB1 glnB1 glnD glnD atoB1 atoB1 mcpA1 mcpA1 gltL1 gltL1 gltK1 gltK1 gltJ1 gltJ1 dctQ2 dctQ2 dcuA dcuA ACN14027.1 ACN14027.1 ACN14102.1 ACN14102.1 atoB2 atoB2 mcpA2 mcpA2 ACN14159.1 ACN14159.1 ACN14172.1 ACN14172.1 ACN14210.1 ACN14210.1 ACN14229.1 ACN14229.1 hysA hysA hysB hysB ACN14294.1 ACN14294.1 ACN14408.1 ACN14408.1 ACN14437.1 ACN14437.1 ACN14481.1 ACN14481.1 mae mae ACN14554.1 ACN14554.1 cydB1 cydB1 cydA1 cydA1 ACN14613.1 ACN14613.1 fixO fixO fixN fixN ACN14679.1 ACN14679.1 pstS4 pstS4 ACN14687.1 ACN14687.1 ACN14733.1 ACN14733.1 motA1 motA1 mcpA3 mcpA3 dnaA dnaA degP degP ACN15071.1 ACN15071.1 ACN15145.1 ACN15145.1 ACN15154.1 ACN15154.1 ACN15189.1 ACN15189.1 dctM4 dctM4 ACN15332.1 ACN15332.1 wecB wecB crp crp ACN15516.1 ACN15516.1 ACN15603.1 ACN15603.1 gumA gumA ACN15676.1 ACN15676.1 ACN15860.1 ACN15860.1 ACN15866.1 ACN15866.1 rpoN rpoN pstS5 pstS5 motA2 motA2 phoR phoR hmeC hmeC ACN16278.1 ACN16278.1 sdhB sdhB sdhA sdhA sdhC sdhC ACN16349.1 ACN16349.1 ACN16403.1 ACN16403.1 ACN16416.1 ACN16416.1 mdtQ mdtQ mcpB2 mcpB2 cheW1 cheW1 cheT cheT cheA1 cheA1 ACN16519.1 ACN16519.1 cheB1 cheB1 cheR1 cheR1 ACN16572.1 ACN16572.1 ACN16597.1 ACN16597.1 flgM flgM cheA2 cheA2 cheW2 cheW2 cheB2 cheB2 cheR2 cheR2 atoB3 atoB3 motA3 motA3 ACN16746.1 ACN16746.1 csrA csrA fliA fliA ACN16791.1 ACN16791.1 cheY cheY ACN16842.1 ACN16842.1 ACN16872.1 ACN16872.1 ACN16876.1 ACN16876.1 dctM8 dctM8 dctQ8 dctQ8 ACN16946.1 ACN16946.1 ACN16951.1 ACN16951.1 ACN16972.1 ACN16972.1 mcp mcp ACN17082.1 ACN17082.1 ACN17096.1 ACN17096.1 cydA2 cydA2 cydB2 cydB2 ACN17216.1 ACN17216.1 ACN17230.1 ACN17230.1 ACN17239.1 ACN17239.1 ACN17240.1 ACN17240.1 ACN17241.1 ACN17241.1 ACN17244.1 ACN17244.1 dctQ9 dctQ9 ACN17346.1 ACN17346.1 ACN17347.1 ACN17347.1 atoE atoE ACN17419.1 ACN17419.1 gltI gltI gltJ2 gltJ2 gltK2 gltK2 gltL2 gltL2 ACN17440.1 ACN17440.1 atoB5 atoB5 ACN17592.1 ACN17592.1 dctM10 dctM10 glnB4 glnB4 glnA2 glnA2 ACN17638.1 ACN17638.1 ACN17722.1 ACN17722.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rndARndA; Cation efflux system family protein RndA (heavy metal, antibiotica resistance); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. (1163 aa)
rndBRndB; Predicted cation efflux system, transmembrane protein RndB (heavy metal, antibiotica resistance); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (506 aa)
narINarI; Nitrate reductase, gamma subunit. (228 aa)
narJNarJ; Nitrate reductase, delta subunit. (188 aa)
narHNarH; Nitrate reductase, beta subunit. (473 aa)
narGNarG; Respiratory nitrate reductase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1232 aa)
ACN13249.1Sigma-54 dependent DNA-binding response regulator. (459 aa)
pstS1PstS1; Phosphate ABC-type transporter, periplasmic phosphate binding protein, part 1. (277 aa)
phoAPhoA; Alkaline phosphatase PhoA; Belongs to the alkaline phosphatase family. (498 aa)
ACN13363.1Two-component hybrid sensor and response regulator histidine kinase (phoR-like protein). (588 aa)
ACN13364.1Two-component DNA-binding response regulator. (233 aa)
pstS3PstS3; Phosphate ABC-type transporter, substrate-binding protein PstS. (271 aa)
ACN13407.1Predicted nitrogen fixation specific regulatory protein AnfA (transcriptional regulator, nifA-family protein). (507 aa)
dctQ1DctQ1; TRAP-type C4-dicarboxylate permease, small subunit DctQ1. (200 aa)
ACN13480.1Putative aerobic respiration control sensor protein ArcB. (549 aa)
ACN13690.1Sigma-54 dependent DNA-binding response regulator (NtrC-type regulator). (451 aa)
ACN13694.1Outer membrane efflux protein. (452 aa)
ACN13731.1Fatty acid desaturase (acyl-lipid desaturase). (341 aa)
glnA1GlnA1; Type I glutamate-ammonia ligase GlnA1 (glutamine synthetase). (470 aa)
glnB1GlnB1; Nitrogen regulatory protein GlnB1 (P-II; transcriptional regulator of glnA); Belongs to the P(II) protein family. (112 aa)
glnDGlnD; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism. (871 aa)
atoB1AtoB1; acetyl-CoA acetyltransferase AtoB1; Belongs to the thiolase-like superfamily. Thiolase family. (416 aa)
mcpA1McpA1; Methyl-accepting chemotaxis protein McpA. (666 aa)
gltL1GltL1; Glutamate/aspartate transport system, ATP-binding protein GltL. (241 aa)
gltK1GltK1; Glutamate/aspartate transport system, permease protein GltK. (218 aa)
gltJ1GltJ1; Glutamate/aspartate transport system, permease protein GltJ. (242 aa)
dctQ2DctQ2; TRAP-type C4-dicarboxylate permease, small subunit DctQ2. (159 aa)
dcuADcuA; Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane; Belongs to the DcuA/DcuB transporter (TC 2.A.13.1) family. (443 aa)
ACN14027.1Methyl-accepting chemotaxis protein. (595 aa)
ACN14102.1Sigma-54 dependent transcriptional regulator. (464 aa)
atoB2AtoB2; acetyl-CoA acetyltransferase AtoB2; Belongs to the thiolase-like superfamily. Thiolase family. (391 aa)
mcpA2McpA2; Methyl-accepting chemotaxis protein McpA. (663 aa)
ACN14159.1Sigma-54 dependent two component DNA-binding response regulator (Fis family protein). (482 aa)
ACN14172.1Hypothetical protein. (59 aa)
ACN14210.1Two-component hybrid sensor and response regulator histidine kinase (Ntr family). (473 aa)
ACN14229.1Putative nitrogen regulation protein (PAS/PAC domain protein). (742 aa)
hysAHysA; Periplasmic [NiFeSe] hydrogenase, large subunit precursor HysA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. (504 aa)
hysBHysB; Periplasmic [NiFeSe] hydrogenase, small subunit precursor HysB. (337 aa)
ACN14294.1Sensory histidine kinase. (229 aa)
ACN14408.1Putative lysylphosphatidylglycerol synthetase (LPG synthetase) (Multiple peptide resistance factor). (849 aa)
ACN14437.1Sigma-54 dependent transcriptional regulator. (475 aa)
ACN14481.1Two component transcriptional regulator (LuxR family protein). (212 aa)
maeMae; NAD/NADP-dependent malate dehydrogenase (malic enzyme) (NAD-ME). (576 aa)
ACN14554.1Sensory box histidine kinase/response regulator. (763 aa)
cydB1CydB1; Cytochrome bd-type ubiquinol oxidase, subunit II (CydB). (339 aa)
cydA1CydA1; Cytochrome bd-type ubiquinol oxidase, subunit I (CydA). (468 aa)
ACN14613.1Two component protein (response regulator/sensory box histidine kinase). (995 aa)
fixOFixO; Cytochrome C oxidase, mono-heme subunit FixO. (310 aa)
fixNFixN; Cytochrome C oxidase, polypeptide subunit FixN (cytochrome cbb3, subunit 1). (430 aa)
ACN14679.1Sensory box histidine kinase/response regulator. (716 aa)
pstS4PstS4; ABC-type phosphate transport system, periplasmic component PstS. (282 aa)
ACN14687.1Conserved hypothetical protein. (491 aa)
ACN14733.1Conserved hypothetical protein. (119 aa)
motA1MotA1; Sodium-driven polar flagellar protein MotA (PomA homolog). (253 aa)
mcpA3McpA3; Methyl-accepting chemotaxis protein McpA. (574 aa)
dnaADnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (469 aa)
degPDegP; Serine protease do-like peptidase DegP; Belongs to the peptidase S1C family. (477 aa)
ACN15071.1Periplasmic polysaccharide export protein. (194 aa)
ACN15145.1Two component protein (cAMP receptor domain/SAM dependent regulatory domain). (495 aa)
ACN15154.1Sigma-54 dependent two component DNA-binding response regulator (Fis family protein). (452 aa)
ACN15189.1Signal transduction family protein (GGDEF domain protein). (305 aa)
dctM4DctM4; TRAP-type C4-dicarboxylate permease, large subunit DctM4. (434 aa)
ACN15332.1Putative pilS, sensory histidne kinase. (437 aa)
wecBWecB; UDP-N-acetylglucosamine 2-epimerase WecB (UDP-GlcNAc-2- epimerase); Belongs to the UDP-N-acetylglucosamine 2-epimerase family. (366 aa)
crpCrp; Transcriptional catabolite gene activator and regulator Crp (cNTP-binding protein). (234 aa)
ACN15516.1TRAP-type C4-dicarboxylate transporter, periplasmic solute-binding protein. (219 aa)
ACN15603.1Sigma-54 dependent two component DNA-binding response regulator (Fis family protein). (349 aa)
gumAGumA; Periplasmic exopolysaccharide export protein GumA. (264 aa)
ACN15676.1Two-component response receiver and regulator protein. (117 aa)
ACN15860.1Putative fimbrial protein PilA precursor. (73 aa)
ACN15866.1Sigma-54 dependent two component DNA-binding response regulator (Fis family protein). (467 aa)
rpoNRpoN; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (479 aa)
pstS5PstS5; ABC-type phosphate transport system, substrate-binding protein PstS. (281 aa)
motA2MotA2; Chemotaxis protein MotA (motility protein A). (256 aa)
phoRPhoR; Alkaline phosphatase synthesis sensor protein PhoR. (505 aa)
hmeCHmeC; Hdr-like menaquinol-oxidizing complex, subunit HmeC. (335 aa)
ACN16278.1Two-component response regulator. (244 aa)
sdhBSdhB; Succinate dehydrogenase/fumarate reductase, iron-sulfur containing subunit SdhB. (244 aa)
sdhASdhA; Succinate dehydrogenase/fumarate reductase, flavoprotein containing subunit SdhA. (656 aa)
sdhCSdhC; Succinate dehydrogenase/fumarate reductase, cytochrome b containing subunit SdhC. (310 aa)
ACN16349.1Sigma-54 dependent DNA-binding response regulator. (457 aa)
ACN16403.1TRAP-type C4-dicarboxylate transport system, large permease component. (425 aa)
ACN16416.1Putative transcriptional response regulator protein. (124 aa)
mdtQMdtQ; Outer membrane multidrug resistance protein MdtQ [precursor]. (444 aa)
mcpB2McpB2; Methyl-accepting chemotaxis protein McpB. (541 aa)
cheW1CheW1; Chemotaxis protein CheW. (170 aa)
cheTCheT; Methyl-accepting chemotaxis transducer protein CheT (Dipeptide chemoreceptor protein). (774 aa)
cheA1CheA1; Chemotaxis histidine kinase protein CheA. (736 aa)
ACN16519.1Putative chemotaxis response regulator receiver (CheY-like). (141 aa)
cheB1CheB1; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (348 aa)
cheR1CheR1; Chemotaxis protein methyltransferase CheR. (260 aa)
ACN16572.1TRAP-type C4-dicarboxylate transport system, small permease component. (155 aa)
ACN16597.1Putative cyclic nucleotide-binding protein. (160 aa)
flgMFlgM; Negative regulator of flagellin synthesis FlgM (anti-sigma-28 factor). (99 aa)
cheA2CheA2; Chemotaxis protein CheA. (1063 aa)
cheW2CheW2; Chemotaxis protein CheW. (149 aa)
cheB2CheB2; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (366 aa)
cheR2CheR2; Chemotaxis protein methyltransferase CheR. (278 aa)
atoB3AtoB3; acetyl-CoA acetyltransferase AtoB3 (acetoacetyl-CoA thiolase); Belongs to the thiolase-like superfamily. Thiolase family. (425 aa)
motA3MotA3; Chemotaxis protein MotA (motility protein A). (298 aa)
ACN16746.1Putative flagellin; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (792 aa)
csrACsrA; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. (81 aa)
fliAFliA; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (238 aa)
ACN16791.1Putative nitrogen assimilation regulatory protein NtrC. (455 aa)
cheYCheY; Chemotaxis protein CheY. (124 aa)
ACN16842.1Sigma-54 dependent DNA-binding response regulator. (470 aa)
ACN16872.1Two-component system response regulator (Ntr family protein). (136 aa)
ACN16876.1Two-component sensory box histidine kinase/response regulator. (144 aa)
dctM8DctM8; TRAP-type C4-dicarboxylate permease, large subunit DctM5. (425 aa)
dctQ8DctQ8; TRAP-type C4-dicarboxylate permease, small subunit DctQ8. (168 aa)
ACN16946.1Two-component sensory box histidine kinase/response regulator. (884 aa)
ACN16951.1Two-component system, cell cycle sensor histidine kinase and response regulator CckA; Cold-shock inducible two-component sensory box histidine kinase /regulatory protein (Ntr family protein). (1036 aa)
ACN16972.1Histidine kinase; Two domain fusion protein (N:Methyl-accepting chemotaxis protein-C:sensory box histidine kinase/response regulator). (1034 aa)
mcpMcp; Methyl-accepting chemotaxis transducer Mcp. (676 aa)
ACN17082.1Sigma-54 dependent DNA-binding response regulator (NtrC family proten). (476 aa)
ACN17096.1Two-component system response regulator (Ntr family protein). (119 aa)
cydA2CydA2; Cytochrome bd-type ubiquinol oxidase, subunit I (CydA). (438 aa)
cydB2CydB2; Cytochrome bd-type ubiquinol oxidase, subunit II (CydB). (338 aa)
ACN17216.1Cyclic nucleotide-binding domain (cNMP-BD) protein. (165 aa)
ACN17230.1Sigma-54 dependent sensory box histidine kinase/response regulator. (461 aa)
ACN17239.1Sigma-54 dependent two component transcriptional regulator. (455 aa)
ACN17240.1Sensory box hisitidine kinase. (659 aa)
ACN17241.1Conserved hypothetical protein. (165 aa)
ACN17244.1Sensory box histidine kinase. (857 aa)
dctQ9DctQ9; TRAP-type C4-dicarboxylate permease, small subunit DctQ9. (172 aa)
ACN17346.1Two-component response regulator (OmpR-like protein). (226 aa)
ACN17347.1Signal transduction histidine kinase. (505 aa)
atoEAtoE; Short-chain fatty acid transporter AtoE. (443 aa)
ACN17419.1Methyl-accepting chemotaxis protein. (699 aa)
gltIGltI; Glutamate/aspartate periplasmic-binding protein [Precursor] GltI. (300 aa)
gltJ2GltJ2; Glutamate/aspartate transport system permease protein GltJ. (240 aa)
gltK2GltK2; Glutamate/aspartate transport system permease protein GltK. (221 aa)
gltL2GltL2; Glutamate/aspartate transport ATP-binding protein GltL. (248 aa)
ACN17440.1Methyl-accepting chemotaxis protein. (548 aa)
atoB5AtoB5; acetyl-CoA acetyltransferase AtoB5 (Acetoacetyl-CoA thiolase); Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
ACN17592.1Signal transduction histidine kinase. (497 aa)
dctM10DctM10; TRAP-type C4-dicarboxylate permease, large subunit DctM10. (430 aa)
glnB4GlnB4; Nitrogen regulatory protein GlnB4 (P-II; transcriptional regulator of glnA); Belongs to the P(II) protein family. (112 aa)
glnA2GlnA2; Type I glutamate-ammonia ligase GlnA2 (glutamine synthetase). (442 aa)
ACN17638.1Response regulator. (465 aa)
ACN17722.1Putative TRAP C4-dicarboxylate transport system permease DctM subunit. (444 aa)
Your Current Organism:
Desulfobacterium autotrophicum
NCBI taxonomy Id: 177437
Other names: D. autotrophicum HRM2, Desulfobacterium autotrophicum HRM2, Desulfobacterium autotrophicum str. HRM2, Desulfobacterium autotrophicum strain HRM2
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