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| | PAE0064 | Translation initiation factor aIF-2 gamma subunit, putative; Protein synthesis; Translation factors. (411 aa) |
| | sod | Superoxide dismutase (sod); Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the iron/manganese superoxide dismutase family. (211 aa) |
| | fusA | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (740 aa) |
| | PAE0626 | Hypothetical protein. (111 aa) |
| | tyrS1 | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (372 aa) |
| | rpoH | DNA-directed RNA polymerase subunit H (rpoH); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family. (75 aa) |
| | PAE0665 | DNA-directed RNA polymerase subunit B (rpoB); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1127 aa) |
| | PAE0666 | DNA-directed RNA polymerase subunit A' (rpoA1); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (884 aa) |
| | rpoA2 | DNA-directed RNA polymerase subunit A'' (rpoA2); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (379 aa) |
| | rpl30e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL30 family. (102 aa) |
| | nusA | Transcription termination factor NusA, putative; Participates in transcription termination. Belongs to the NusA family. (144 aa) |
| | rps12 | Ribosomal protein S12; With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. Belongs to the universal ribosomal protein uS12 family. (147 aa) |
| | rpoD | DNA-directed RNA polymerase subunit D (rpoD); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family. (260 aa) |
| | rpl18e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL18 family. (122 aa) |
| | rpl13 | Ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (187 aa) |
| | rps9 | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uS9 family. (146 aa) |
| | rpoN | DNA-directed RNA polymerase subunit N (rpoN); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoN/eukaryotic RPB10 RNA polymerase subunit family. (66 aa) |
| | PAE0676 | Small nuclear ribonucleoprotein homolog (Sm-like); Transcription; RNA processing. (85 aa) |
| | PAE0680 | Conserved hypothetical protein. (306 aa) |
| | PAE0694 | Conserved hypothetical protein. (65 aa) |
| | ef1b | Translation elongation factor aEF-1 beta subunit; Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. (92 aa) |
| | aspS | aspartyl-tRNA synthetase; Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp- AMP and then transferred to the acceptor end of tRNA(Asp). (428 aa) |
| | PAE0705 | Conserved hypothetical protein. (173 aa) |
| | rps7 | Ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center; Belongs to the universal ribosomal protein uS7 family. (223 aa) |
| | PAE0759 | GTP binding protein, conjectural; Unclassified; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (258 aa) |
| | tfe | Conserved hypothetical protein; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes [...] (170 aa) |
| | PAE0790 | Small nuclear ribonucleoprotein homolog (Sm-like); Transcription; RNA processing. (80 aa) |
| | rpl2 | Ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (246 aa) |
| | rps17e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eS17 family. (71 aa) |
| | PAE0805 | FKBP-type peptidyl-prolyl cis-trans isomerases; Protein fate; Protein modification and repair. (229 aa) |
| | rps2 | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uS2 family. (208 aa) |
| | cysS | cysteinyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation. (474 aa) |
| | rpl14e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL14 family. (103 aa) |
| | truB | tRNA pseudouridine synthase B; Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 2 subfamily. (333 aa) |
| | hel308 | ATP-dependent, DNA binding helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (704 aa) |
| | gatD | Asparaginase (asnA); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (417 aa) |
| | eIF1A | Translation initiation factor aIF-1A; Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits (By similarity). (97 aa) |
| | leuS | leucyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (945 aa) |
| | PAE1165 | Hypothetical protein. (183 aa) |
| | rps5 | Ribosomal protein S5; With S4 and S12 plays an important role in translational accuracy. (218 aa) |
| | rpl30 | Protein synthesis; Ribosomal proteins: synthesis and modification. (178 aa) |
| | tmcA | Conserved hypothetical protein; Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP). (788 aa) |
| | eif2b | Translation initiation factor aIF-2B beta subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-beta/eIF-5 family. (134 aa) |
| | PAE1379 | long-chain-fatty-acid--CoA ligase; Fatty acid and phospholipid metabolism; Degradation. (577 aa) |
| | pheS | phenylalanyl-tRNA synthetase alpha subunit; Protein synthesis; tRNA aminoacylation; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. (489 aa) |
| | rps6e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eS6 family. (148 aa) |
| | infB | Translation initiation factor IF-2 (infB), putative; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (589 aa) |
| | PAE1525 | Glu-tRNA(Gln) amidotransferase subunit A (gatA); Protein synthesis; tRNA aminoacylation. (399 aa) |
| | hisS | histidyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-II aminoacyl-tRNA synthetase family. (419 aa) |
| | ndk | Nucleoside diphosphate kinase (ndk); Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). (195 aa) |
| | PAE1611 | Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair. (662 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (981 aa) |
| | rpl13e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL13 family. (159 aa) |
| | tfb | Transcription initiation factor IIB (TFIIB); Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). (333 aa) |
| | PAE1653 | Conserved hypothetical protein. (294 aa) |
| | pheT | phenylalanyl-tRNA synthetase beta subunit; Protein synthesis; tRNA aminoacylation. (515 aa) |
| | PAE1702 | Conserved hypothetical protein. (502 aa) |
| | rpl12 | Ribosomal protein L12; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the eukaryotic ribosomal protein P1/P2 family. (110 aa) |
| | rps19 | Ribosomal protein S19; Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. (158 aa) |
| | rps17 | Ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (146 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. (608 aa) |
| | rpl29 | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uL29 family. (75 aa) |
| | rps3 | Ribosomal protein S3; Binds the lower part of the 30S subunit head. Belongs to the universal ribosomal protein uS3 family. (196 aa) |
| | rpl22 | Ribosomal protein L22; This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (168 aa) |
| | rpl15e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL15 family. (191 aa) |
| | lysS | lysyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-II aminoacyl-tRNA synthetase family. (482 aa) |
| | PAE1922 | UDP-glucose 4-epimerase (galE-1); Cell envelope; Biosynthesis and degradation of surface polysaccharides and lipopolysaccharides. (314 aa) |
| | tyrS2 | tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (316 aa) |
| | rpl3 | Ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (338 aa) |
| | rpl4 | Ribosomal protein L4; One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. (283 aa) |
| | rpl23 | Ribosomal protein L23; Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Belongs to the universal ribosomal protein uL23 family. (81 aa) |
| | csl4 | Conserved protein (RNA polymerase related); Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. (178 aa) |
| | rpoL | DNA-directed RNA polymerase subunit L (rpoL); DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoL/eukaryotic RPB11/RPC19 RNA polymerase subunit family. (92 aa) |
| | nep1 | Conserved hypothetical protein; Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. (221 aa) |
| | rps14 | Ribosomal protein S14; Binds 16S rRNA, required for the assembly of 30S particles. (54 aa) |
| | rps8 | Ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (130 aa) |
| | rpl32e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL32 family. (152 aa) |
| | rpl19e | Ribosomal protein L19; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL19 family. (147 aa) |
| | rpl18 | Ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (205 aa) |
| | dnaG | Conserved protein (toprim domain); RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. (408 aa) |
| | map | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (291 aa) |
| | PAE2117 | Thermosome (chaperonin) alpha subunit; Protein fate; Protein folding and stabilization; Belongs to the TCP-1 chaperonin family. (549 aa) |
| | tbp | Transcription initiation factor TFIID (TATA-binding); General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation. (199 aa) |
| | proS | prolyl-tRNA synthetase; Catalyzes the attachment of proline to tRNA(Pro) in a two- step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). (488 aa) |
| | PAE2169 | Protein synthesis; Ribosomal proteins: synthesis and modification. (98 aa) |
| | rps25e | Conserved hypothetical protein; Belongs to the eukaryotic ribosomal protein eS25 family. (110 aa) |
| | pfdB | Conserved hypothetical protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity). (126 aa) |
| | PAE2201 | Conserved hypothetical protein; Probably involved in the biogenesis of the ribosome. (181 aa) |
| | rpl37ae | Ribosomal protein L37; Binds to the 23S rRNA. (105 aa) |
| | rrp42 | 3' exoribonuclease family protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. (274 aa) |
| | rrp41 | 3' exoribonuclease family protein; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. (246 aa) |
| | rrp4 | Conserved hypothetical protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. (235 aa) |
| | PAE2209 | Conserved hypothetical protein. (232 aa) |
| | rpoP | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoP/eukaryotic RPC10 RNA polymerase subunit family. (52 aa) |
| | PAE2266 | glycyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation. (586 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner (By similarity); Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (799 aa) |
| | PAE2352 | RNase L inhibitor homolog; Unclassified. (590 aa) |
| | rpl6 | Ribosomal protein L6; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family. (196 aa) |
| | rps27ae | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eS31 family. (65 aa) |
| | rps24e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eS24 family. (121 aa) |
| | PAE2466 | long-chain-fatty-acid--CoA ligase; Fatty acid and phospholipid metabolism; Degradation. (422 aa) |
| | PAE2557 | asparaginyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation. (348 aa) |
| | prf1 | Peptide chain release factor aRF subunit 1; Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA. (388 aa) |
| | rps10 | Ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (106 aa) |
| | metG | methionyl-tRNA synthetase alpha subunit; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. (570 aa) |
| | uppS | Conserved hypothetical protein; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids. (238 aa) |
| | PAE2942a | methionyl-tRNA synthetase beta subunit; Protein synthesis; tRNA aminoacylation. (108 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (570 aa) |
| | PAE2973 | asparaginyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation. (431 aa) |
| | PAE2991 | Conserved hypothetical protein. (580 aa) |
| | tuf | Translation elongation factor aEF-1 alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (444 aa) |
| | nop10 | Conserved hypothetical protein; Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. (72 aa) |
| | eif2a | Translation initiation factor aIF-2 alpha subunit; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. Belongs to the eIF-2-alpha family. (265 aa) |
| | rps27e | Protein synthesis; Ribosomal proteins: synthesis and modification. (67 aa) |
| | rpl44e | Ribosomal protein L44; Binds to the 23S rRNA. (91 aa) |
| | PAE3040 | Transcription; DNA-dependent RNA polymerase; Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (110 aa) |
| | rps19e | Ribosomal protein S19; May be involved in maturation of the 30S ribosomal subunit. Belongs to the eukaryotic ribosomal protein eS19 family. (158 aa) |
| | PAE3044 | Conserved hypothetical protein; Belongs to the PDCD5 family. (110 aa) |
| | rpl39e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL39 family. (18 aa) |
| | rps4 | Ribosomal protein S4; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit. (159 aa) |
| | rps13 | Ribosomal protein S13; Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement; Belongs to the universal ribosomal protein uS13 family. (152 aa) |
| | trpS | tryptophanyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (375 aa) |
| | rpl31e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL31 family. (91 aa) |
| | eif6 | Translation initiation factor aIF-6; Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. (220 aa) |
| | rpl18a | Protein synthesis; Ribosomal proteins: synthesis and modification. (78 aa) |
| | pfdA | Conserved hypothetical protein; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding (By similarity). (132 aa) |
| | PAE3100 | Signal recognition particle protein (docking protein), probable; Protein fate; Protein and peptide secretion and trafficking. (305 aa) |
| | PAE3102 | Hypothetical protein. (99 aa) |
| | spt5 | Transcription antitermination protein nusG, putative; Stimulates transcription elongation; Belongs to the archaeal Spt5 family. (153 aa) |
| | rpl11 | Ribosomal protein L11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors; Belongs to the universal ribosomal protein uL11 family. (167 aa) |
| | rpl1 | Ribosomal protein L1; Binds directly to 23S rRNA. Probably involved in E site tRNA release. (222 aa) |
| | rpl10 | Acidic ribosomal protein P0 (L10E); Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (345 aa) |
| | rpl14 | Ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (144 aa) |
| | serS | seryl-tRNA synthetase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (451 aa) |
| | PAE3165 | GTP binding protein, putative; Unclassified. (399 aa) |
| | rps11 | Ribosomal protein S11; Located on the platform of the 30S subunit. Belongs to the universal ribosomal protein uS11 family. (133 aa) |
| | rsmA | Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily. (228 aa) |
| | gatE | Glu-tRNA(Gln) amidotransferase subunit B (gatB); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (608 aa) |
| | ribL34e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL34 family. (84 aa) |
| | cmk | Cytidylate kinase (cmk); Purines, pyrimidines, nucleosides, and nucleotides; Nucleotide and nucleoside interconversions. (184 aa) |
| | flpA | Fibrillarin-like pre-rRNA processing protein (flpA); Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA; Belongs to the methyltransferase superfamily. Fibrillarin family. (235 aa) |
| | PAE3232 | Nop family pre-rRNA processing protein; Transcription; RNA processing. (421 aa) |
| | rpl40e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL40 family. (53 aa) |
| | rpoK | DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal RpoK/eukaryotic RPB6 RNA polymerase subunit family. (106 aa) |
| | PAE3273 | Thermosome (chaperonin) beta subunit; Protein fate; Protein folding and stabilization; Belongs to the TCP-1 chaperonin family. (553 aa) |
| | pelA | Cell division protein pelota (pelA), conjectural; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (332 aa) |
| | rpl24 | Ribosomal protein L24; One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. (123 aa) |
| | rps4e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eS4 family. (238 aa) |
| | PAE3329 | Transcription initiation factor IIB (TFIIB); Transcription; Transcription factors. (298 aa) |
| | PAE3330 | Hypothetical protein. (66 aa) |
| | rps8e | Protein synthesis; Ribosomal proteins: synthesis and modification. (131 aa) |
| | srp19 | Signal recognition particle; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. (95 aa) |
| | rpl21e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eL21 family. (100 aa) |
| | PAE3335 | Conserved hypothetical protein. (111 aa) |
| | PAE3336 | Conserved hypothetical protein. (194 aa) |
| | eif5a | Translation initiation factor aIF-5A; Functions by promoting the formation of the first peptide bond; Belongs to the eIF-5A family. (132 aa) |
| | PAE3340 | Translation initiation factor SUI1 homolog; Protein synthesis; Translation factors; Belongs to the SUI1 family. (120 aa) |
| | argS | arginyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (630 aa) |
| | rps28e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eS28 family. (77 aa) |
| | rpl24e | Ribosomal protein L24; Binds to the 23S rRNA. (58 aa) |
| | rpl7ae | Ribosomal protein L7; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (151 aa) |
| | srp54 | Signal recognition particle (srp54 family), putative; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (433 aa) |
| | thiI | Thiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (484 aa) |
| | PAE3435 | Preprotein translocase secY subunit; Protein fate; Protein and peptide secretion and trafficking; Belongs to the SecY/SEC61-alpha family. (459 aa) |
| | rpl15 | Ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (156 aa) |
| | rps3ae | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the eukaryotic ribosomal protein eS1 family. (221 aa) |
| | PAE3473 | Conserved hypothetical protein. (175 aa) |
| | PAE3474 | Conserved hypothetical protein. (266 aa) |
| | PAE3480 | Transcription associated protein, conjectural; Transcription; DNA-dependent RNA polymerase. (89 aa) |
| | rps15 | Protein synthesis; Ribosomal proteins: synthesis and modification. (151 aa) |
| | dys | Deoxyhypusine synthase; Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. (292 aa) |
| | PAE3526 | Hypothetical protein. (401 aa) |
| | PAE3562 | DNA-directed RNA polymerase subunit E' (rpoE1); Transcription; DNA-dependent RNA polymerase. (191 aa) |
| | spt4 | DNA-directed RNA polymerase subunit E'' (rpoE2); Stimulates transcription elongation; Belongs to the archaeal Spt4 family. (73 aa) |
| | rpl10e | Protein synthesis; Ribosomal proteins: synthesis and modification; Belongs to the universal ribosomal protein uL16 family. (180 aa) |
| | rpl5 | Ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (179 aa) |
| | rtcA | RNA 3'-terminal phosphate cyclase; Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. (348 aa) |
| | PAE3626 | Conserved hypothetical protein. (346 aa) |
| | PAE3631 | NAD dependent epimerase/dehydratase, putative; Purines, pyrimidines, nucleosides, and nucleotides; Sugar-nucleotide biosynthesis and conversions. (302 aa) |
