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| | PAE1850 | rRNA intron-encoded homing endonuclease, possible; Unclassified. (219 aa) |
| | PAE0098 | Hypothetical protein. (327 aa) |
| | vapC-2 | Hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (126 aa) |
| | PAE0106 | Hypothetical protein. (205 aa) |
| | PAE0114 | Conserved hypothetical protein. (308 aa) |
| | PAE0117 | Hypothetical protein. (476 aa) |
| | PAE0119 | Hypothetical protein. (551 aa) |
| | PAE0121 | Hypothetical protein. (329 aa) |
| | PAE0128 | Conserved hypothetical protein. (535 aa) |
| | PAE0129 | Conserved hypothetical protein. (149 aa) |
| | PAE0131 | Hypothetical protein. (85 aa) |
| | vapC3 | Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system. Has ribonuclease activity; Belongs to the PINc/VapC protein family. (131 aa) |
| | PAE0163 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. (157 aa) |
| | PAE0165 | Conserved hypothetical protein. (114 aa) |
| | PAE0170 | Conserved protein (tenA homolog); Unclassified. (212 aa) |
| | PAE0181 | Conserved hypothetical protein. (262 aa) |
| | PAE0198 | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (190 aa) |
| | cas2-2 | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (91 aa) |
| | cas1-2 | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (295 aa) |
| | PAE0207 | Conserved hypothetical protein. (255 aa) |
| | PAE0208 | Helicase, probable; Unclassified. (554 aa) |
| | PAE0212 | Hypothetical; Conserved within genome. (254 aa) |
| | folD | Methylenetetrahydrofolate dehydrogenase (folD); Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (311 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase I (FGAM synthase I) (purQ); Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL a [...] (212 aa) |
| | PAE0239 | Conserved hypothetical protein. (293 aa) |
| | PAE0243 | Hypothetical protein. (470 aa) |
| | PAE0245 | Conserved hypothetical protein. (602 aa) |
| | PAE0252 | Diadenosine 5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase (mutT/nudix family protein); DNA metabolism; DNA replication, recombination, and repair. (143 aa) |
| | PAE0262 | Prohibitin homolog (hflK family); Unclassified. (335 aa) |
| | PAE0264 | Signal peptidase; Protein fate; Protein and peptide secretion and trafficking. (188 aa) |
| | PAE0267 | Intracellular protease; Protein fate; Degradation of proteins, peptides, and glycopeptides. (196 aa) |
| | PAE0285 | Conserved hypothetical protein. (130 aa) |
| | PAE0294 | P. aerophilum family 322 protein. (274 aa) |
| | PAE0309 | Chlorohydrolase, conjectural; Unclassified. (351 aa) |
| | PAE0318 | Hypothetical protein. (538 aa) |
| | pyrC | Dihydroorotase (pyrC); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (383 aa) |
| | fusA | Translation elongation factor aEF-2; Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF [...] (740 aa) |
| | PAE0337 | Conserved hypothetical protein. (146 aa) |
| | PAE0371 | Conserved hypothetical protein. (331 aa) |
| | PAE0518 | Conserved hypothetical protein. (152 aa) |
| | PAE0563 | ADP ribose hydrolase, putative (mutT/nudix family protein); DNA metabolism; DNA replication, recombination, and repair. (170 aa) |
| | uppP | Bacitracin resistence protein; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). (266 aa) |
| | PAE0626 | Hypothetical protein. (111 aa) |
| | PAE0632 | Conserved hypothetical protein. (476 aa) |
| | PAE0637 | Peptidase (possible proline dipeptidase); Protein fate; Degradation of proteins, peptides, and glycopeptides; Belongs to the peptidase M24B family. (340 aa) |
| | paudg | Uracil DNA glycosylase (Pa-UDGa); Removes uracil bases that are present in DNA as a result of either deamination of cytosine or misincorporation of dUMP instead of dTMP. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair as well as from single-stranded DNA. Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. (196 aa) |
| | nfi | DNA endonuclease V, conjectural; DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. (215 aa) |
| | PAE0696 | AAA family ATPase, possible cell division control protein cdc48; Cellular processes; Cell division. (731 aa) |
| | fen | DNA endonuclease rad2 homolog; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) [...] (346 aa) |
| | pth | Conserved hypothetical protein; The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. (120 aa) |
| | PAE0712 | Surface layer-associated STABLE protease, conjectural; Protein fate; Degradation of proteins, peptides, and glycopeptides; Belongs to the peptidase S8 family. (1258 aa) |
| | PAE0714 | Diadenosine 5'5'''-P1,P4-tetraphosphate pyrophosphohydrolase (mutT/nudix family protein); DNA metabolism; DNA replication, recombination, and repair. (145 aa) |
| | rfcS1 | Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (329 aa) |
| | rfcL | Replication factor C large subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcL subfamily. (422 aa) |
| | PAE0749 | Conserved protein (nfeD homolog); Unclassified. (428 aa) |
| | PAE0750 | Conserved protein (band 7 homolog); Unclassified. (262 aa) |
| | PAE0754 | H+-transporting ATP synthase subunit C (atpC); Energy metabolism; ATP-proton motive force interconversion. (87 aa) |
| | PAE0759 | GTP binding protein, conjectural; Unclassified; Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. (258 aa) |
| | hflX | Conserved protein (possible hflX); GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family. (386 aa) |
| | PAE0789 | Hypothetical protein. (96 aa) |
| | PAE0793 | Conserved protein (possible ATP binding); Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (307 aa) |
| | PAE0794 | Cytidine deaminase; Purines, pyrimidines, nucleosides, and nucleotides; Pyrimidine ribonucleotide biosynthesis. (127 aa) |
| | psmB1 | Proteasome beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (202 aa) |
| | PAE0810 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. (105 aa) |
| | PAE0840 | Conserved hypothetical protein. (126 aa) |
| | PAE0872 | Conserved hypothetical protein. (193 aa) |
| | PAE0875 | Competence damage protein, conjectural; DNA metabolism; DNA replication, recombination, and repair; Belongs to the CinA family. (266 aa) |
| | PAE0880 | DNA-(apurinic or apyrimidinic site) lyase (endonuclease III, PaNth); DNA metabolism; DNA replication, recombination, and repair. (223 aa) |
| | PAE0885 | Thermostable carboxypeptidase; Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. (491 aa) |
| | PAE0890 | Conserved hypothetical protein; Belongs to the acylphosphatase family. (92 aa) |
| | PAE0891 | Hypothetical protein. (269 aa) |
| | hel308 | ATP-dependent, DNA binding helicase; DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks. (704 aa) |
| | PAE0901 | DNA replication licensing factor (mcm); DNA metabolism; DNA replication, recombination, and repair; Belongs to the MCM family. (680 aa) |
| | fbp | Conserved hypothetical protein; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (399 aa) |
| | hisH | Amidotransferase (hisH); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (190 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (131 aa) |
| | PAE0966 | Conserved hypothetical protein. (193 aa) |
| | PAE0967 | Conserved hypothetical protein. (176 aa) |
| | PAE0971 | Conserved hypothetical protein. (160 aa) |
| | hisE | phosphoribosyl-ATP pyrophosphohydrolase; Amino acid biosynthesis; Histidine family. (94 aa) |
| | PAE1002 | Acylamino-acid-releasing enzyme, conjectural; Protein fate; Protein modification and repair. (627 aa) |
| | gatD | Asparaginase (asnA); Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate. (417 aa) |
| | PAE1004 | Conserved hypothetical protein. (176 aa) |
| | PAE1058 | Glycerophosphoryl diester phosphodiesterase; Fatty acid and phospholipid metabolism; Degradation. (229 aa) |
| | PAE1087 | Conserved hypothetical protein. (210 aa) |
| | PAE1099 | Integral membrane protein (rhomboid related), putative; Unclassified. (230 aa) |
| | PAE1105 | Conserved hypothetical protein. (119 aa) |
| | leuS | leucyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (945 aa) |
| | rgy | Reverse gyrase; Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication; In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family. (1228 aa) |
| | PAE1111 | Conserved hypothetical protein. (182 aa) |
| | PAE1124 | Integral membrane protein (rhomboid related), putative; Unclassified. (232 aa) |
| | PAE1159 | Hypothetical protein. (112 aa) |
| | PAE1186 | Conserved hypothetical protein. (198 aa) |
| | PAE1189 | Acylamino-acid-releasing enzyme, conjectural; Protein fate; Protein modification and repair. (570 aa) |
| | rnhB | Ribonuclease HII (rnhB); Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (212 aa) |
| | nadE | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (267 aa) |
| | acyP | Acylphosphatase, putative; Fatty acid and phospholipid metabolism; Other. (95 aa) |
| | PAE1272 | Trehalose-6-phosphate synthase; Cellular processes; Adaptations to atypical conditions. (737 aa) |
| | PAE1302 | Tricorn protease; Degrades oligopeptides; Belongs to the peptidase S41B family. (1016 aa) |
| | PAE1327 | uracil-DNA glycosylase (Pa-UDGb); DNA glycosylase with broad substrate specificity. Can remove uracil from double-stranded DNA containing either a U/G or U/A base pair. Can also process hydroxymethyluracil (mispaired with guanine or adenine), hypoxanthine and fluorouracil. Exhibits a clear preference for double-stranded DNA substrates, but can also process uracil in single-stranded DNA, with lower efficiency. Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family. (226 aa) |
| | PAE1329 | Conserved hypothetical protein; Belongs to the thioesterase PaaI family. (147 aa) |
| | PAE1385 | Aminopeptidase from family M42; Unclassified. (362 aa) |
| | PAE1427 | Arsenical pump-driving ATPase; Transport and binding proteins; Anions. (300 aa) |
| | PAE1433 | P. aerophilum family 322 protein part 1, authentic frameshift. (178 aa) |
| | PAE1434 | P. aerophilum family 322 protein part 2, authentic frameshift. (94 aa) |
| | PAE1465 | Conserved hypothetical protein, part 1 authentic frameshift. (70 aa) |
| | PAE1467 | Conserved hypothetical protein, part 2 authentic frameshift. (200 aa) |
| | PAE1474 | Aminopeptidase from family M42; Unclassified. (315 aa) |
| | infB | Translation initiation factor IF-2 (infB), putative; Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. (589 aa) |
| | PAE1522 | Hypothetical protein. (291 aa) |
| | PAE1536 | Conserved protein (possible dual specificity phosphatase); Unclassified. (195 aa) |
| | PAE1540 | Conserved protein (possibly metallo-beta-lactamase superfamily); Unclassified. (207 aa) |
| | folE | GTP cyclohydrolase I; Biosynthesis of cofactors, prosthetic groups, and carriers; Folic acid. (187 aa) |
| | PAE1597 | Aminopeptidase; Unclassified. (822 aa) |
| | PAE1599 | Hypothetical protein. (203 aa) |
| | PAE1611 | Helicase, possible DNA repair rad25; DNA metabolism; DNA replication, recombination, and repair. (662 aa) |
| | ileS | isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (981 aa) |
| | PAE1636 | Conserved hypothetical protein. (329 aa) |
| | rfcS2 | Replication factor C small subunit; Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA; Belongs to the activator 1 small subunits family. RfcS subfamily. (319 aa) |
| | PAE1649 | GTP-binding protein; Unclassified. (389 aa) |
| | PAE1677 | Conserved hypothetical protein. (134 aa) |
| | PAE1683 | Hypothetical protein. (187 aa) |
| | PAE1693 | TBP-interacting protein TIP49; Transcription; Transcription factors. (450 aa) |
| | PAE1702 | Conserved hypothetical protein. (502 aa) |
| | PAE1727 | Protease, conjectural; Protein fate; Degradation of proteins, peptides, and glycopeptides. (275 aa) |
| | PAE1735 | Conserved hypothetical protein. (216 aa) |
| | PAE1736 | Beta-glucosidase; Energy metabolism; Sugars; Belongs to the glycosyl hydrolase 1 family. (343 aa) |
| | thrS | threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr); Belongs to the class-II aminoacyl-tRNA synthetase family. (608 aa) |
| | PAE1763 | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (214 aa) |
| | PAE1764 | GTP-binding protein; Unclassified. (517 aa) |
| | PAE1765 | Hypothetical protein. (33 aa) |
| | hppA | Vacuolar-type H+-pyrophosphatase; Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force; Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily. (721 aa) |
| | PAE1777 | Protein synthesis; Ribosomal proteins: synthesis and modification. (80 aa) |
| | PAE1785 | Conserved hypothetical protein. (227 aa) |
| | PAE1792 | Hypothetical protein. (191 aa) |
| | nucS | Conserved hypothetical protein; Cleaves both 3' and 5' ssDNA extremities of branched DNA structures; Belongs to the NucS endonuclease family. (250 aa) |
| | PAE1819 | Hypothetical protein. (476 aa) |
| | PAE1826 | Hypothetical protein. (142 aa) |
| | PAE1829 | Hypothetical protein. (81 aa) |
| | PAE1830 | Hypothetical protein. (176 aa) |
| | PAE0090 | Conserved hypothetical protein. (362 aa) |
| | PAE1869 | paREP11. (139 aa) |
| | PAE1905 | P. aerophilum family 322 protein part 2, authentic frameshift. (159 aa) |
| | PAE1906 | P. aerophilum family 322 protein part 1, authentic frameshift. (88 aa) |
| | PAE1915 | Hypothetical protein. (185 aa) |
| | PAE1918 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. (136 aa) |
| | PAE1949 | paREP11. (85 aa) |
| | PAE1968 | Alpha-glucosidase; Energy metabolism; Sugars; Belongs to the glycosyl hydrolase 31 family. (684 aa) |
| | PAE1982 | Aerolysin, part 1, authentic frameshift; Protein fate; Degradation of proteins, peptides, and glycopeptides. (174 aa) |
| | PAE1983 | Aerolysin, part 2, authentic frameshift; Protein fate; Degradation of proteins, peptides, and glycopeptides. (214 aa) |
| | amzA | Conserved hypothetical protein; Probable zinc metalloprotease whose natural substrate is unknown. (155 aa) |
| | PAE2003 | Conserved hypothetical protein. (234 aa) |
| | PAE2004 | Serine/threonine specific protein phosphatase; Regulatory functions; General. (279 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (176 aa) |
| | PAE2017 | Phosphoserine phosphatase (serB); Amino acid biosynthesis; Serine family. (216 aa) |
| | PAE2024 | Conserved hypothetical protein. (122 aa) |
| | PAE2025 | xaa-Pro dipeptidase, putative; Protein fate; Degradation of proteins, peptides, and glycopeptides. (323 aa) |
| | PAE2028 | N-methylhydantoinase B (hyuB); Amino acid biosynthesis; Glutamate family. (516 aa) |
| | PAE2030 | N-methylhydantoinase A (hyuA); Amino acid biosynthesis; Glutamate family. (647 aa) |
| | PAE2032 | paREP11. (135 aa) |
| | PAE2038 | Hypothetical protein. (310 aa) |
| | PAE2039 | moxR related protein; Regulatory functions; General. (301 aa) |
| | PAE2050 | Conserved hypothetical protein. (285 aa) |
| | PAE2075 | Nitrilase, conjectural; Unclassified. (258 aa) |
| | map | Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val); Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily. (291 aa) |
| | PAE2117 | Thermosome (chaperonin) alpha subunit; Protein fate; Protein folding and stabilization; Belongs to the TCP-1 chaperonin family. (549 aa) |
| | PAE2130 | ATP-dependent helicase, putative; Unclassified. (914 aa) |
| | PAE2138 | Conserved hypothetical protein. (297 aa) |
| | PAE2160 | Conserved hypothetical protein; Belongs to the UPF0173 family. (225 aa) |
| | hjc | Holliday Junction Resolvase; A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products; Belongs to the Holliday junction resolvase Hjc family. (133 aa) |
| | rrp42 | 3' exoribonuclease family protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. (274 aa) |
| | rrp41 | 3' exoribonuclease family protein; Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails. (246 aa) |
| | psmA | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (243 aa) |
| | PAE2237 | Conserved hypothetical protein; DNA repair enzyme that is part of the base excision repair (BER) pathway; protects from oxidative damage by removing the major product of DNA oxidation, 8-oxoguanine (GO), from single- and double- stranded DNA substrates; Belongs to the archaeal N-glycosylase/DNA lyase (AGOG) family. (256 aa) |
| | PAE2240 | Conserved hypothetical protein. (304 aa) |
| | PAE2243 | Conserved hypothetical protein. (254 aa) |
| | PAE2253 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. (157 aa) |
| | PAE2260 | Agmatinase (speB); Central intermediary metabolism; Polyamine biosynthesis; Belongs to the arginase family. (267 aa) |
| | endA | tRNA intron endonuclease; Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp. (183 aa) |
| | PAE2293 | Hypothetical protein. (191 aa) |
| | valS | valyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner (By similarity); Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (799 aa) |
| | PAE2317 | alanyl-tRNA synthetase related protein; Protein synthesis; tRNA aminoacylation. (238 aa) |
| | dtdA | Conserved hypothetical protein; D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo. (251 aa) |
| | PAE2335 | Possible succinyl-diaminopimelate desuccinylase; Amino acid biosynthesis; Aspartate family. (397 aa) |
| | PAE2362 | ATP-dependent helicase; Unclassified. (928 aa) |
| | PAE2365 | Nucleoside-triphosphatase (NTPase); Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. (187 aa) |
| | PAE2388 | Hypothetical protein. (243 aa) |
| | PAE2439 | Hypothetical; Conserved within genome. (115 aa) |
| | PAE2446 | DNA metabolism; DNA replication, recombination, and repair. (451 aa) |
| | PAE2469 | Conserved hypothetical protein. (131 aa) |
| | PAE2506 | paREP11. (250 aa) |
| | PAE2539 | Conserved hypothetical protein. (282 aa) |
| | PAE2544 | Conserved hypothetical protein. (604 aa) |
| | PAE2552 | Conserved hypothetical protein. (244 aa) |
| | PAE2565 | Conserved hypothetical protein. (167 aa) |
| | PAE2578 | Conserved hypothetical protein. (288 aa) |
| | PAE2641 | Hypothetical protein. (186 aa) |
| | PAE2676 | Conserved hypothetical protein. (125 aa) |
| | PAE2688 | 2-hydroxyhepta-2,4-diene-1,7-dioate isomerase, conjectural; Central intermediary metabolism; Other. (306 aa) |
| | vapC9 | Conserved hypothetical protein; Toxic component of a type II toxin-antitoxin (TA) system (By similarity). Has ribonuclease activity. Has a slow ssDNA exonuclease activity; Belongs to the PINc/VapC protein family. (133 aa) |
| | PAE2758 | Cation-transporting ATPase (P-type); Transport and binding proteins; Cations. (789 aa) |
| | PAE2759 | Conserved hypothetical protein. (120 aa) |
| | PAE2792 | Conserved hypothetical protein part 1, authentic frameshift. (200 aa) |
| | PAE2794 | Protease IV, conjectural; Protein fate; Degradation of proteins, peptides, and glycopeptides. (548 aa) |
| | PAE2794a | Conserved hypothetical protein part 2, authentic frameshift. (111 aa) |
| | PAE2795 | Serine protease; Protein fate; Degradation of proteins, peptides, and glycopeptides. (315 aa) |
| | lysK | Peptidase family M20/M25/M40; Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine. (341 aa) |
| | PAE2808 | Conserved hypothetical protein; Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. (178 aa) |
| | pdxT | Conserved hypothetical protein; Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS. (204 aa) |
| | vapC-3 | Conserved hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (137 aa) |
| | PAE2870 | paREP11. (99 aa) |
| | PAE2901 | Conserved hypothetical protein. (368 aa) |
| | PAE2902 | Hypothetical protein. (423 aa) |
| | PAE2903 | Conserved hypothetical protein. (608 aa) |
| | PAE2904 | Exonuclease sbcD, conjectural; DNA metabolism; DNA replication, recombination, and repair. (385 aa) |
| | PAE2905 | Purine NTPase, probable; Unclassified. (702 aa) |
| | surE1 | surE stationary-phase survival protein homolog; Nucleotidase that shows the greatest phosphatase activity on purine (deoxy)nucleoside 5'-monophosphates, particularly the substrates 5'-GMP, 5'-AMP and 2'-deoxy-5'-AMP; Belongs to the SurE nucleotidase family. (266 aa) |
| | PAE2918 | tldD, putative modulator of DNA gyrase; DNA metabolism; DNA replication, recombination, and repair. (457 aa) |
| | PAE2919 | pmbA, putative modulator of DNA gyrase; DNA metabolism; DNA replication, recombination, and repair. (427 aa) |
| | PAE2947 | Conserved hypothetical protein. (250 aa) |
| | cobB1 | Conserved hypothetical protein; NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription; Belongs to the sirtuin family. Class U subfamily. (254 aa) |
| | PAE2972 | Conserved hypothetical protein; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily. (194 aa) |
| | PAE2981 | Acetylpolyamine aminohydrolase, putative; Energy metabolism; Amino acids and amines. (336 aa) |
| | PAE2983 | Conserved hypothetical protein. (209 aa) |
| | gch3 | Conserved hypothetical protein; Catalyzes the formation of 2-amino-5-formylamino-6- ribofuranosylamino-4(3H)-pyrimidinone ribonucleotide monophosphate and inorganic phosphate from GTP. Also has an independent pyrophosphate phosphohydrolase activity; Belongs to the archaeal-type GTP cyclohydrolase family. (221 aa) |
| | PAE2991 | Conserved hypothetical protein. (580 aa) |
| | PAE2998 | Conserved hypothetical protein. (521 aa) |
| | tuf | Translation elongation factor aEF-1 alpha subunit; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. (444 aa) |
| | PAE3001 | Isochorismatase, putative; Biosynthesis of cofactors, prosthetic groups, and carriers; Other. (201 aa) |
| | PAE3003 | Conserved hypothetical protein. (126 aa) |
| | PAE3023 | Carbon nitrogen hydrolase, conjectural; Unclassified. (250 aa) |
| | PAE3055 | Extragenic suppressor protein suhB homolog; Regulatory functions; General. (250 aa) |
| | PAE3083 | Asparaginase; Energy metabolism; Amino acids and amines. (299 aa) |
| | PAE3100 | Signal recognition particle protein (docking protein), probable; Protein fate; Protein and peptide secretion and trafficking. (305 aa) |
| | PAE3113 | Conserved hypothetical protein. (142 aa) |
| | PAE3124 | Penicillin amidase; Unclassified. (696 aa) |
| | ahcY | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. (437 aa) |
| | PAE3171 | AAA family ATPase, possible cell division control protein cdc48; Cellular processes; Cell division. (738 aa) |
| | PAE3189 | Conserved hypothetical protein. (223 aa) |
| | PAE3193a | Possible heat shock protein, htpX homolog part 1, authentic frameshift; Cellular processes; Adaptations to atypical conditions. (139 aa) |
| | PAE3195 | Possible heat shock protein, htpX homolog part 2, authentic frameshift; Cellular processes; Adaptations to atypical conditions. (194 aa) |
| | PAE3199 | U/G & T/G mismatch specific glycosylase (Pa-MIG); DNA glycosylase that excises thymine from T/G mismatches and uracil from U/G mismatches. Can also process T/GO and U/GO, but not A/G, T/C and U/C. Has weak AP lyase activity. (230 aa) |
| | PAE3204 | Hypothetical protein. (422 aa) |
| | PAE3211 | Conserved hypothetical protein. (231 aa) |
| | rnz | Conserved hypothetical protein; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family. (287 aa) |
| | PAE3237 | Beta-lactamase-like protein; Cellular processes; Toxin production and resistance. (448 aa) |
| | PAE3257 | DNA-(apurinic or apyrimidinic site) lyase (endonuclease IV); DNA metabolism; DNA replication, recombination, and repair. (275 aa) |
| | PAE3273 | Thermosome (chaperonin) beta subunit; Protein fate; Protein folding and stabilization; Belongs to the TCP-1 chaperonin family. (553 aa) |
| | PAE3282 | Conserved hypothetical protein. (235 aa) |
| | pelA | Cell division protein pelota (pelA), conjectural; May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity. (332 aa) |
| | PAE3292 | Conserved hypothetical protein; Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency; Belongs to the THEP1 NTPase family. (173 aa) |
| | PAE3301 | mutT/nudix family protein; DNA metabolism; DNA replication, recombination, and repair. (146 aa) |
| | PAE3309 | mRNA 3'-end processing factor, conjectural; Transcription; RNA processing. (430 aa) |
| | PAE3323 | Conserved hypothetical protein. (264 aa) |
| | PAE3326 | Conserved hypothetical protein; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. (187 aa) |
| | PAE3333 | Conserved hypothetical protein. (249 aa) |
| | rpl7ae | Ribosomal protein L7; Multifunctional RNA-binding protein that recognizes the K- turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs. (151 aa) |
| | srp54 | Signal recognition particle (srp54 family), putative; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. (433 aa) |
| | guaA | GMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (505 aa) |
| | PAE3376 | Beta-lactamase-like protein; Cellular processes; Toxin production and resistance. (314 aa) |
| | PAE3381 | Beta-lactamase-like protein; Cellular processes; Toxin production and resistance. (194 aa) |
| | PAE3404 | Acyl coenzyme A thioester hydrolase; Fatty acid and phospholipid metabolism; Other. (313 aa) |
| | PAE3418 | Conserved hypothetical protein. (314 aa) |
| | PAE3428 | Conserved hypothetical protein. (457 aa) |
| | htpX | Heat shock protein, htpX homolog, conjectural; Cellular processes; Adaptations to atypical conditions; Belongs to the peptidase M48B family. (347 aa) |
| | PAE3481 | Conserved hypothetical protein. (153 aa) |
| | PAE3495 | Conserved hypothetical protein; Catalyzes the dephosphorylation of 2-phosphoglycolate. (228 aa) |
| | PAE3498 | Hypothetical protein. (243 aa) |
| | PAE3499 | Conserved hypothetical protein. (111 aa) |
| | cobB2 | Conserved hypothetical protein; NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form. Deacetylates the N-terminal lysine residue of Alba, the major archaeal chromatin protein and that, in turn, increases Alba's DNA binding affinity, thereby repressing transcription. Belongs to the sirtuin family. Class III subfamily. (249 aa) |
| | PAE3507 | Conserved hypothetical protein. (554 aa) |
| | pyrG | CTP synthase (pyrG); Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (530 aa) |
| | surE2 | surE stationary-phase survival protein homolog; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (249 aa) |
| | PAE3526 | Hypothetical protein. (401 aa) |
| | PAE3547 | Heat shock protein, htpX homolog, conjectural; Cellular processes; Adaptations to atypical conditions. (296 aa) |
| | PAE3561 | Conserved hypothetical protein. (110 aa) |
| | alaS | alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (892 aa) |
| | PAE3573 | Conserved hypothetical protein. (196 aa) |
| | PAE3577 | Conserved hypothetical protein. (168 aa) |
| | PAE3582 | Conserved hypothetical protein; Belongs to the UPF0237 family. (90 aa) |
| | psmB2 | Proteasome, beta subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. (203 aa) |
| | PAE3640 | Hypothetical protein. (98 aa) |
| | PAE3679 | Protease IV, conjectural; Protein fate; Degradation of proteins, peptides, and glycopeptides. (608 aa) |
| | PAE3687 | Hypothetical protein. (359 aa) |
| | PAE0005 | Peptidase, putative; Protein fate; Degradation of proteins, peptides, and glycopeptides. (308 aa) |
| | PAE0028 | paREP11. (249 aa) |
| | fau-1 | Conserved hypothetical protein; Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. (443 aa) |
| | vapC | Conserved hypothetical protein; Toxic component of a toxin-antitoxin (TA) system. An RNase. Belongs to the PINc/VapC protein family. (125 aa) |
| | PAE0036 | Conserved hypothetical protein. (223 aa) |
| | PAE0055 | Hypothetical protein. (627 aa) |
| | PAE0064 | Translation initiation factor aIF-2 gamma subunit, putative; Protein synthesis; Translation factors. (411 aa) |
| | PAE0067 | Conserved hypothetical protein. (272 aa) |
| | PAE0068 | Helicase, probable; Unclassified. (609 aa) |
| | PAE0075 | Conserved hypothetical protein. (246 aa) |
| | PAE0079 | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family. (171 aa) |
| | cas2-1 | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (95 aa) |
| | cas1-1 | Conserved hypothetical protein; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (302 aa) |
