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PAE3646 PAE3646 PAE2384 PAE2384 PAE2575 PAE2575 PAE2609 PAE2609 PAE0374 PAE0374 PAE0376 PAE0376 tyrS1 tyrS1 leuS leuS PAE0683 PAE0683 PAE0685 PAE0685 PAE0721 PAE0721 PAE0722 PAE0722 cysS cysS coaD coaD PAE2672 PAE2672 argG argG metG metG gltX gltX nadE nadE PAE1438 PAE1438 ileS ileS PAE1738 PAE1738 tyrS2 tyrS2 PAE1989 PAE1989 queC queC PAE2259 PAE2259 PAE2295 PAE2295 valS valS trpS trpS argS argS guaA guaA thiI thiI PAE3586 PAE3586 PAE3587 PAE3587
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PAE3646Conserved hypothetical protein. (298 aa)
PAE2384Universal stress protein family; Cellular processes; Adaptations to atypical conditions. (137 aa)
PAE2575Phosphoadenosine phosphosulfate reductase (PAPS reductase); Central intermediary metabolism; Sulfur metabolism. (267 aa)
PAE2609Sulfate adenylyltransferase; Central intermediary metabolism; Sulfur metabolism. (455 aa)
PAE0374Conserved hypothetical protein. (201 aa)
PAE0376Asparagine synthetase (asnB); Amino acid biosynthesis; Aspartate family. (274 aa)
tyrS1tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (372 aa)
leuSleucyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (945 aa)
PAE0683Cytidyltransferase; Unclassified. (228 aa)
PAE0685Conserved protein (probable universal stress protein homolog); Cellular processes; Adaptations to atypical conditions. (133 aa)
PAE0721Electron transfer flavoprotein alpha subunit (etfA); Energy metabolism; Electron transport. (346 aa)
PAE0722Electron transfer flavoprotein beta subunit (etfB); Energy metabolism; Electron transport. (264 aa)
cysScysteinyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation. (474 aa)
coaDConserved protein (possible cytidylyltransferase); Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the eukaryotic CoaD family. (155 aa)
PAE2672Conserved hypothetical protein. (229 aa)
argGArgininosuccinate synthase (argG); Amino acid biosynthesis; Glutamate family; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (316 aa)
metGmethionyl-tRNA synthetase alpha subunit; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily. (570 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). (570 aa)
nadENH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. (267 aa)
PAE1438Cytidylyltransferase; Unclassified. (178 aa)
ileSisoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily. (981 aa)
PAE1738Conserved hypothetical protein. (141 aa)
tyrS2tyrosyl-tRNA synthetase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily. (316 aa)
PAE1989Conserved hypothetical protein. (595 aa)
queCConserved hypothetical protein; Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (269 aa)
PAE2259Conserved protein (possible cytidylyltransferase); Unclassified. (168 aa)
PAE2295Conserved hypothetical protein. (324 aa)
valSvalyl-tRNA synthetase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner (By similarity); Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily. (799 aa)
trpStryptophanyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (375 aa)
argSarginyl-tRNA synthetase; Protein synthesis; tRNA aminoacylation; Belongs to the class-I aminoacyl-tRNA synthetase family. (630 aa)
guaAGMP synthetase (glutamine-hydrolysing); Catalyzes the synthesis of GMP from XMP. (505 aa)
thiIThiamine biosynthesis protein (thiI), probable; Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS. (484 aa)
PAE3586Electron transfer flavoprotein beta subunit (etfB); Energy metabolism; Electron transport. (256 aa)
PAE3587Electron transfer flavoprotein alpha subunit (etfA); Energy metabolism; Electron transport. (299 aa)
Your Current Organism:
Pyrobaculum aerophilum
NCBI taxonomy Id: 178306
Other names: P. aerophilum str. IM2, Pyrobaculum aerophilum IM2, Pyrobaculum aerophilum str. IM2, Pyrobaculum aerophilum strain IM2
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