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ilvC ilvC ilvD_2 ilvD_2 hmp_1 hmp_1 mmgD mmgD GCA_001049355_00623 GCA_001049355_00623 leuD leuD leuC leuC gltA2 gltA2 citA citA GCA_001049355_02508 GCA_001049355_02508 mdlC_1 mdlC_1 oxc oxc ilvE_1 ilvE_1 fxsA fxsA hmp_6 hmp_6 argC argC argJ argJ argB argB argD argD icd icd ilvD_1 ilvD_1 GCA_001049355_05357 GCA_001049355_05357 ilvB ilvB argA argA budB budB aspC aspC yjiR yjiR leuA leuA lysC lysC asd asd acnA acnA mdlC_2 mdlC_2 ilvE_2 ilvE_2 gabR gabR ydcR ydcR GCA_001049355_03248 GCA_001049355_03248 ilvB1 ilvB1 ilvH ilvH leuB leuB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ilvCUnannotated protein; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (337 aa)
ilvD_2Unannotated protein; Belongs to the IlvD/Edd family. (584 aa)
hmp_1Unannotated protein; Belongs to the globin family. (406 aa)
mmgDUnannotated protein. (260 aa)
GCA_001049355_00623Unannotated protein. (284 aa)
leuDUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (197 aa)
leuCUnannotated protein; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (481 aa)
gltA2Unannotated protein; Belongs to the citrate synthase family. (434 aa)
citAUnannotated protein; Belongs to the citrate synthase family. (373 aa)
GCA_001049355_02508Unannotated protein. (421 aa)
mdlC_1Unannotated protein; Belongs to the TPP enzyme family. (538 aa)
oxcUnannotated protein; Belongs to the TPP enzyme family. (570 aa)
ilvE_1Unannotated protein. (367 aa)
fxsAUnannotated protein. (174 aa)
hmp_6Unannotated protein. (585 aa)
argCUnannotated protein; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa)
argJUnannotated protein; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (398 aa)
argBUnannotated protein; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (301 aa)
argDUnannotated protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (392 aa)
icdUnannotated protein. (745 aa)
ilvD_1Unannotated protein; Belongs to the IlvD/Edd family. (566 aa)
GCA_001049355_05357Unannotated protein. (432 aa)
ilvBUnannotated protein; Belongs to the TPP enzyme family. (532 aa)
argAUnannotated protein. (152 aa)
budBUnannotated protein; Belongs to the TPP enzyme family. (554 aa)
aspCUnannotated protein. (384 aa)
yjiRUnannotated protein. (449 aa)
leuAUnannotated protein; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (603 aa)
lysCUnannotated protein; Belongs to the aspartokinase family. (432 aa)
asdUnannotated protein; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (344 aa)
acnAUnannotated protein; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (938 aa)
mdlC_2Unannotated protein. (518 aa)
ilvE_2Unannotated protein. (340 aa)
gabRUnannotated protein. (473 aa)
ydcRUnannotated protein. (480 aa)
GCA_001049355_03248Unannotated protein. (301 aa)
ilvB1Unannotated protein. (626 aa)
ilvHUnannotated protein. (170 aa)
leuBUnannotated protein; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (340 aa)
Your Current Organism:
Mycolicibacterium aurum
NCBI taxonomy Id: 1791
Other names: ATCC 23366, CCUG 37666, CIP 104465, DSM 43999, HAMBI 2275, JCM 6366, LMG 19255, LMG:19255, M. aurum, Mycobacterium aurum, NCTC 10437, NRRL B-4037
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