STRINGSTRING
KLO54425.1 KLO54425.1 bmr3_1 bmr3_1 KLO50287.1 KLO50287.1 glnA3 glnA3 KLO54436.1 KLO54436.1 iclR_2 iclR_2 KLO50731.1 KLO50731.1 nixA nixA ziaR_3 ziaR_3 lutR_6 lutR_6 ycdF_2 ycdF_2 feaB feaB KLO50964.1 KLO50964.1 glnA_3 glnA_3 plaP_1 plaP_1 KLO51054.1 KLO51054.1 glnD glnD glnB glnB amt_1 amt_1 kdgR_2 kdgR_2 mdlY mdlY kipI_2 kipI_2 KLO51266.1 KLO51266.1 KLO51267.1 KLO51267.1 plaP_3 plaP_3 KLO54609.1 KLO54609.1 fic fic KLO54676.1 KLO54676.1 pdhR_4 pdhR_4 puuP_10 puuP_10 KLO54678.1 KLO54678.1 glnT_1 glnT_1 KLO51726.1 KLO51726.1 KLO51727.1 KLO51727.1 ophA1_3 ophA1_3 sad_1 sad_1 puuP_16 puuP_16 glnA_4 glnA_4 php php pdxS_2 pdxS_2 tpa_3 tpa_3 KLO52494.1 KLO52494.1 betB_2 betB_2 KLO52495.1 KLO52495.1 adhE2_2 adhE2_2 KLO52497.1 KLO52497.1 kipI_1 kipI_1 KLO52523.1 KLO52523.1 KLO52565.1 KLO52565.1 KLO54881.1 KLO54881.1 KLO52876.1 KLO52876.1 mgtE mgtE KLO53139.1 KLO53139.1 soxB soxB gltB_4 gltB_4 KLO53142.1 KLO53142.1 glmS_2 glmS_2 glnT_2 glnT_2 amt_3 amt_3 codB codB rutB_1 rutB_1 ydfH_4 ydfH_4 pxpA pxpA KLO55025.1 KLO55025.1 KLO53649.1 KLO53649.1 KLO53650.1 KLO53650.1 KLO53651.1 KLO53651.1 KLO53652.1 KLO53652.1 KLO53653.1 KLO53653.1 KLO54302.1 KLO54302.1 rutA_6 rutA_6 KLO48455.1 KLO48455.1 glnE glnE glnA_1 glnA_1 tap_2 tap_2 tap_1 tap_1 kstR2_5 kstR2_5 KLO48462.1 KLO48462.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLO54425.1Lactoylglutathione lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
bmr3_1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (686 aa)
KLO50287.1Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
glnA3Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (456 aa)
KLO54436.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (121 aa)
iclR_2IclR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (253 aa)
KLO50731.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
nixANickel transporter; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NiCoT transporter (TC 2.A.52) family. (368 aa)
ziaR_3ArsR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
lutR_6GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
ycdF_2Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (257 aa)
feaBAldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (454 aa)
KLO50964.1Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
glnA_3Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (455 aa)
plaP_1Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
KLO51054.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
glnDprotein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (821 aa)
glnBNitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
amt_1Ammonia channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
kdgR_2IclR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
mdlYCatalyzes the hydrolysis of allophanate; Derived by automated computational analysis using gene prediction method: Protein Homology. (553 aa)
kipI_2Urea amidolyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (664 aa)
KLO51266.1Urea carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
KLO51267.1Urea carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
plaP_3Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
KLO54609.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (316 aa)
ficCell filamentation protein Fic; Derived by automated computational analysis using gene prediction method: Protein Homology. (291 aa)
KLO54676.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
pdhR_4Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (245 aa)
puuP_10Amino acid permease; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
KLO54678.1Cytochrome P450; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cytochrome P450 family. (396 aa)
glnT_1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (461 aa)
KLO51726.1Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
KLO51727.1Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
ophA1_3Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
sad_1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
puuP_16Amino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (470 aa)
glnA_4Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (436 aa)
phpHypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
pdxS_2Pyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (305 aa)
tpa_3Class III aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
KLO52494.1Peptidase C26; Derived by automated computational analysis using gene prediction method: Protein Homology. (241 aa)
betB_2Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (454 aa)
KLO52495.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (121 aa)
adhE2_2Alcohol dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (362 aa)
KLO52497.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
kipI_1Allophanate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
KLO52523.1Allophanate hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
KLO52565.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
KLO54881.1Twin-arginine translocation pathway signal; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
KLO52876.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
mgtEMagnesium transporter; Acts as a magnesium transporter. (458 aa)
KLO53139.1XRE family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
soxBFAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
gltB_4Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (430 aa)
KLO53142.1Protein glxC; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
glmS_2Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
glnT_2Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (434 aa)
amt_3Ammonia channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
codBCobalamin biosynthesis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
rutB_1Cysteine hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)
ydfH_4GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
pxpAHypothetical protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate. (253 aa)
KLO55025.1IclR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
KLO53649.1Amino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (479 aa)
KLO53650.1Betaine-aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
KLO53651.1Amino acid transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (487 aa)
KLO53652.1Tyramine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (648 aa)
KLO53653.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (132 aa)
KLO54302.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
rutA_6Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
KLO48455.1Thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
glnEBifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (999 aa)
glnA_1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (446 aa)
tap_2Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
tap_1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa)
kstR2_5TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
KLO48462.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
Your Current Organism:
Mycolicibacterium senegalense
NCBI taxonomy Id: 1796
Other names: ATCC 35796, CCUG 21001, CIP 104941, DSM 43656, JCM 15467, Mycobacterium farcinogenes subsp. senegalense, Mycobacterium senegalense, NCTC 10956, strain IEMVT 378
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