STRINGSTRING
KLO54425.1 KLO54425.1 bmr3_1 bmr3_1 KLO50287.1 KLO50287.1 glnA3 glnA3 KLO54436.1 KLO54436.1 KLO50731.1 KLO50731.1 KLO51054.1 KLO51054.1 glnD glnD glnB glnB amt_1 amt_1 KLO52565.1 KLO52565.1 KLO54881.1 KLO54881.1 KLO52876.1 KLO52876.1 rutA_6 rutA_6 KLO48455.1 KLO48455.1 glnE glnE glnA_1 glnA_1 tap_2 tap_2 tap_1 tap_1 kstR2_5 kstR2_5 KLO48462.1 KLO48462.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLO54425.1Lactoylglutathione lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
bmr3_1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (686 aa)
KLO50287.1Carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (160 aa)
glnA3Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (456 aa)
KLO54436.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (121 aa)
KLO50731.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
KLO51054.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
glnDprotein-PII uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. (821 aa)
glnBNitrogen regulatory protein P-II 1; Indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
amt_1Ammonia channel protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
KLO52565.1Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
KLO54881.1Twin-arginine translocation pathway signal; Derived by automated computational analysis using gene prediction method: Protein Homology. (259 aa)
KLO52876.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (117 aa)
rutA_6Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (285 aa)
KLO48455.1Thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
glnEBifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] (999 aa)
glnA_1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (446 aa)
tap_2Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (503 aa)
tap_1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (511 aa)
kstR2_5TetR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
KLO48462.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
Your Current Organism:
Mycolicibacterium senegalense
NCBI taxonomy Id: 1796
Other names: ATCC 35796, CCUG 21001, CIP 104941, DSM 43656, JCM 15467, Mycobacterium farcinogenes subsp. senegalense, Mycobacterium senegalense, NCTC 10956, strain IEMVT 378
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.