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KLO52135.1 KLO52135.1 aceA_1 aceA_1 gcvH gcvH gcvP gcvP glcB glcB KLO54432.1 KLO54432.1 glnA3 glnA3 mutB mutB mutA mutA acnA acnA lip2_1 lip2_1 srpA srpA lip2_2 lip2_2 psrA psrA lip2_3 lip2_3 gorA gorA glnA_3 glnA_3 lip2_4 lip2_4 glxK glxK lip2_5 lip2_5 narB_3 narB_3 KLO51215.1 KLO51215.1 thlA_2 thlA_2 purU_2 purU_2 KLO51266.1 KLO51266.1 KLO51267.1 KLO51267.1 KLO51280.1 KLO51280.1 KLO51451.1 KLO51451.1 accD5_2 accD5_2 accC accC mdh mdh katE_2 katE_2 glnT_1 glnT_1 KLO51903.1 KLO51903.1 KLO51974.1 KLO51974.1 dmdA_1 dmdA_1 aceA_2 aceA_2 lpd_1 lpd_1 KLO52222.1 KLO52222.1 serA_2 serA_2 dmlA dmlA KLO52467.1 KLO52467.1 glnA_4 glnA_4 fadI fadI lip2_8 lip2_8 KLO52588.1 KLO52588.1 lipC lipC lip2_9 lip2_9 KLO54883.1 KLO54883.1 aes aes KLO52933.1 KLO52933.1 accD5_3 accD5_3 phnX phnX glnT_2 glnT_2 acs acs ghrB ghrB hprA hprA fdhF_4 fdhF_4 fadA6_1 fadA6_1 fadA5 fadA5 KLO53424.1 KLO53424.1 KLO53450.1 KLO53450.1 fadA_1 fadA_1 citA citA gltA2 gltA2 bclA_1 bclA_1 KLO53664.1 KLO53664.1 KLO53757.1 KLO53757.1 accA1_1 accA1_1 arsC_1 arsC_1 pcaF_2 pcaF_2 glyA glyA KLO55108.1 KLO55108.1 KLO55116.1 KLO55116.1 ygbM ygbM KLO54305.1 KLO54305.1 KLO54313.1 KLO54313.1 KLO48325.1 KLO48325.1 merA merA KLO48381.1 KLO48381.1 gcvT gcvT glnA_2 glnA_2 glnA_1 glnA_1 KLO48471.1 KLO48471.1 accD5_1 accD5_1 amdA amdA fdhF_2 fdhF_2 gltA1 gltA1 accA1_2 accA1_2 KLO48852.1 KLO48852.1 scpA_2 scpA_2 scpA_1 scpA_1 KLO48917.1 KLO48917.1 KLO48918.1 KLO48918.1 amiE_1 amiE_1 KLO47470.1 KLO47470.1 KLO47519.1 KLO47519.1 KLO47523.1 KLO47523.1 KLO47382.1 KLO47382.1 KLO47385.1 KLO47385.1 KLO46871.1 KLO46871.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLO52135.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (173 aa)
aceA_1Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (760 aa)
gcvHGlycine cleavage system protein H; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. (131 aa)
gcvPGlycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. (944 aa)
glcBMalate synthase; Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl- CoA) and glyoxylate to form malate and CoA; Belongs to the malate synthase family. GlcB subfamily. (741 aa)
KLO54432.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (495 aa)
glnA3Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (456 aa)
mutBmethylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate; Derived by automated computational analysis using gene prediction method: Protein Homology. (753 aa)
mutAmethylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (624 aa)
acnAAconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (942 aa)
lip2_1Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology. (315 aa)
srpACatalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family. (346 aa)
lip2_2Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
psrAMolybdopterin dinucleotide-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (749 aa)
lip2_3Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology. (318 aa)
gorACatalyzes the reduction of mycothione or glutathione to mycothione or glutathione disulfide; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
glnA_3Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (455 aa)
lip2_4Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (307 aa)
glxKGlycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glycerate kinase type-1 family. (373 aa)
lip2_5Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
narB_3Formate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (740 aa)
KLO51215.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (382 aa)
thlA_2acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (404 aa)
purU_2Formyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (296 aa)
KLO51266.1Urea carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
KLO51267.1Urea carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
KLO51280.1HAD family hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (229 aa)
KLO51451.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (410 aa)
accD5_2methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (542 aa)
accCacetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (597 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (328 aa)
katE_2Catalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (484 aa)
glnT_1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (461 aa)
KLO51903.13-hydroxyacyl-ACP dehydratase; Functions as a heterodimer along with HadA or HadC in fatty acid biosynthesis; fatty acid synthase type II; FAS-II; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
KLO51974.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
dmdA_1Aconitate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (651 aa)
aceA_2Isocitrate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
lpd_1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
KLO52222.1Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (312 aa)
serA_22-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
dmlATartrate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (365 aa)
KLO52467.1Molybdopterin dinucleotide-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (763 aa)
glnA_4Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (436 aa)
fadIacetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (433 aa)
lip2_8Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
KLO52588.1FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (457 aa)
lipCEsterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (407 aa)
lip2_9Alpha/beta hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
KLO54883.1Dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
aesCarboxylesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (301 aa)
KLO52933.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
accD5_3methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
phnXHaloacid dehalogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
glnT_2Glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (434 aa)
acsacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (653 aa)
ghrBHydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa)
hprA2-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (317 aa)
fdhF_4Molybdopterin-binding oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (738 aa)
fadA6_1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (382 aa)
fadA5acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (383 aa)
KLO53424.1Lipid-transfer protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (385 aa)
KLO53450.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
fadA_1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (403 aa)
citACitrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (372 aa)
gltA2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (434 aa)
bclA_1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (565 aa)
KLO53664.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
KLO53757.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (508 aa)
accA1_1acetyl-CoA carboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (644 aa)
arsC_1Arsenate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ArsC family. (112 aa)
pcaF_2acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (405 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (487 aa)
KLO55108.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
KLO55116.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (66 aa)
ygbMHydroxypyruvate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the hyi family. (261 aa)
KLO54305.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
KLO54313.1FAD-linked oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (451 aa)
KLO48325.1Pyridine nucleotide-disulfide oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
merAMercuric reductase; Enables the enzymatic reduction of mercuric ions to elemental mercury; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
KLO48381.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
gcvTGlycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine. (365 aa)
glnA_2Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
glnA_1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (446 aa)
KLO48471.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (225 aa)
accD5_1propionyl-CoA carboxylase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
amdAFormamidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
fdhF_2Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (763 aa)
gltA1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
accA1_2acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (665 aa)
KLO48852.1Cyclase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
scpA_2methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (131 aa)
scpA_1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (529 aa)
KLO48917.1acetyl-CoA acetyltransferase; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (392 aa)
KLO48918.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
amiE_1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
KLO47470.1acetyl-CoA carboxylase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (660 aa)
KLO47519.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (157 aa)
KLO47523.1Thiolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (394 aa)
KLO47382.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (459 aa)
KLO47385.1Mercuric reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (479 aa)
KLO46871.1Lipase; Derived by automated computational analysis using gene prediction method: Protein Homology. (366 aa)
Your Current Organism:
Mycolicibacterium senegalense
NCBI taxonomy Id: 1796
Other names: ATCC 35796, CCUG 21001, CIP 104941, DSM 43656, JCM 15467, Mycobacterium farcinogenes subsp. senegalense, Mycobacterium senegalense, NCTC 10956, strain IEMVT 378
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