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AMR79535.1 AMR79535.1 AMR81959.1 AMR81959.1 pyrC-2 pyrC-2 AMR82417.1 AMR82417.1 pyrD-2 pyrD-2 AMR81763.1 AMR81763.1 AMR81516.1 AMR81516.1 AMR81472.1 AMR81472.1 AMR82381.1 AMR82381.1 AMR81222.1 AMR81222.1 AMR81145.1 AMR81145.1 upp-2 upp-2 AMR81038.1 AMR81038.1 AMR80971.1 AMR80971.1 AMR82338.1 AMR82338.1 AMR80770.1 AMR80770.1 AMR82331.1 AMR82331.1 AMR80746.1 AMR80746.1 AMR80736.1 AMR80736.1 AMR80581.1 AMR80581.1 AMR79853.1 AMR79853.1 AMR79851.1 AMR79851.1 pyrF pyrF tgt tgt AMR79714.1 AMR79714.1 AMR79713.1 AMR79713.1 ppnP ppnP AMR79688.1 AMR79688.1 dcd dcd AMR80384.1 AMR80384.1 pyrB pyrB AMR79533.1 AMR79533.1 nrdR nrdR AMR80374.1 AMR80374.1 thyA thyA carA carA carB carB AMR79021.1 AMR79021.1 surE surE ndk ndk pyrH pyrH AMR78593.1 AMR78593.1 AMR78517.1 AMR78517.1 AMR78481.1 AMR78481.1 AMR78305.1 AMR78305.1 tmk tmk AMR78039.1 AMR78039.1 AMR77970.1 AMR77970.1 AMR77923.1 AMR77923.1 AMR77834.1 AMR77834.1 AMR80252.1 AMR80252.1 AMR77623.1 AMR77623.1 pyrD pyrD AMR77554.1 AMR77554.1 pyrG pyrG AMR77454.1 AMR77454.1 AMR77357.1 AMR77357.1 AMR77343.1 AMR77343.1 upp upp cmk cmk groS groS AMR77051.1 AMR77051.1 pyrC pyrC AMR76724.1 AMR76724.1 pyrE pyrE AMR76513.1 AMR76513.1 AMR76481.1 AMR76481.1 AMR76417.1 AMR76417.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AMR79535.1Bifunctional pyr operon transcriptional regulator/uracil phosphoribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (178 aa)
AMR81959.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (335 aa)
pyrC-2Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (347 aa)
AMR82417.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
pyrD-2Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (316 aa)
AMR81763.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
AMR81516.1Acid phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (317 aa)
AMR81472.1Endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (603 aa)
AMR82381.1Bifunctional metallophosphatase/5'-nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (547 aa)
AMR81222.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
AMR81145.1Cytosine deaminase; Catalyzes the deamination of cytosine to uracil and ammonia; Derived by automated computational analysis using gene prediction method: Protein Homology. (428 aa)
upp-2Uracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (228 aa)
AMR81038.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
AMR80971.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
AMR82338.1tRNA-specific adenosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
AMR80770.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
AMR82331.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (523 aa)
AMR80746.1NAD(P)H nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
AMR80736.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (69 aa)
AMR80581.1Zn-dependent hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
AMR79853.1Ribonucleotide-diphosphate reductase subunit alpha; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (979 aa)
AMR79851.1Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (395 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the OMP decarboxylase family. Type 2 subfamily. (272 aa)
tgttRNA-guanine(34) transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form [...] (376 aa)
AMR79714.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
AMR79713.1Dihydropyrimidinase; Catalyzes the hydrolytic cleavage of imides that range from linear to heterocyclic and that include hydantoins, dihydropyrimidines, and phthalimides; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
ppnPHypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (103 aa)
AMR79688.1Aminotransferase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. (166 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (188 aa)
AMR80384.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (190 aa)
pyrBAspartate carbamoyltransferase catalytic subunit; Catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (323 aa)
AMR79533.1Dihydroorotase; Catalyzes the reversible hydrolysis of the amide bond within dihydroorotate. This metabolic intermediate is required for the biosynthesis of pyrimidine nucleotides; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (154 aa)
AMR80374.1Rossman fold protein, TIGR00730 family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (239 aa)
thyAThymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
carACarbamoyl-phosphate synthase small subunit; Catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
carBCarbamoyl phosphate synthase large subunit; Four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (1082 aa)
AMR79021.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (831 aa)
surE5'/3'-nucleotidase SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (250 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (236 aa)
AMR78593.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (258 aa)
AMR78517.1NAD(P)H nitroreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (211 aa)
AMR78481.1Nitroreductase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (196 aa)
AMR78305.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (428 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (203 aa)
AMR78039.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
AMR77970.1Phosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (212 aa)
AMR77923.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (444 aa)
AMR77834.1Thymidine phosphorylase; Catalyzes the formation of thymine and 2-deoxy-alpha-D-ribose 1-phosphate from thymidine; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
AMR80252.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (74 aa)
AMR77623.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
pyrDDihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (346 aa)
AMR77554.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (423 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (550 aa)
AMR77454.1Nitroreductase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
AMR77357.1Peptidoglycan-binding protein LysM; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
AMR77343.1Rossman fold protein, TIGR00730 family; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LOG family. (194 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (216 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (222 aa)
groSCo-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (96 aa)
AMR77051.1Nucleoside 2-deoxyribosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (344 aa)
AMR76724.123S rRNA methyltransferase; SAM-dependent;catalyzes the methylation of cytosine at position 1962 of the 23S rRNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (233 aa)
AMR76513.1Nucleotide pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (107 aa)
AMR76481.1Restriction endonuclease subunit R; Derived by automated computational analysis using gene prediction method: Protein Homology. (929 aa)
AMR76417.1Peptigoglycan-binding protein LysM; Derived by automated computational analysis using gene prediction method: Protein Homology. (396 aa)
Your Current Organism:
Cupriavidus nantongensis
NCBI taxonomy Id: 1796606
Other names: C. nantongensis, Cupriavidus nantongensis Sun et al. 2016, Cupriavidus sp. X1, KCTC 42909, LMG 29218, LMG:29218, strain X1
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