(47 nodes) Histidine metabolism network (Cupriavidus nantongensis)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	AMR80575.1	Amine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
	AMR80755.1	Amino acid oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
	AMR76374.1	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
	hutG	Formimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (316 aa)
	AMR76656.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (467 aa)
	AMR76891.1	Class II glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (276 aa)
	hutG-2	Formimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family. (323 aa)
	hutU	Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (561 aa)
	AMR77123.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (478 aa)
	hisC	Histidinol-phosphate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (376 aa)
	AMR77418.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
	AMR77419.1	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
	AMR77543.1	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (287 aa)
	AMR77593.1	Hydroxydechloroatrazine ethylaminohydrolase; Catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (462 aa)
	AMR78229.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
	AMR78244.1	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
	AMR78254.1	Class II glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (292 aa)
	AMR78285.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (471 aa)
	AMR78455.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (477 aa)
	hisD	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (430 aa)
	hisZ	ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (383 aa)
	AMR79319.1	Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
	AMR79320.1	Dimethylhistidine N-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
	AMR79651.1	N-formylglutamate deformylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (270 aa)
	AMR79652.1	Formimidoylglutamate deiminase; Catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (468 aa)
	hutI	Imidazolonepropionase; Catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
	hutU-2	Urocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (566 aa)
	AMR80973.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (476 aa)
	hutH	Catalyzes the degradation of histidine to urocanate and ammmonia; Derived by automated computational analysis using gene prediction method: Protein Homology. (524 aa)
	hisC-2	Histidinol-phosphate transaminase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (356 aa)
	AMR79852.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
	AMR79942.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
	AMR79962.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (505 aa)
	AMR79995.1	Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
	hisE	phosphoribosyl-ATP pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (123 aa)
	hisI	phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (134 aa)
	hisF	Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (256 aa)
	A2G96_27475	Hypothetical protein; Internal stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
	hisA	1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase; Catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
	hisH	Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (217 aa)
	hisB	Imidazoleglycerol-phosphate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
	hisC-3	Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (366 aa)
	hisD-2	Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (445 aa)
	hisG	ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (224 aa)
	AMR81205.1	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (473 aa)
	AMR80507.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
	A2G96_27105	Hypothetical protein; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)

Your Current Organism:

Cupriavidus nantongensis

NCBI taxonomy Id: 1796606
Other names: C. nantongensis, Cupriavidus nantongensis Sun et al. 2016, Cupriavidus sp. X1, KCTC 42909, LMG 29218, LMG:29218, strain X1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AMR76374.1	AMR77419.1	A2G96_00665	A2G96_06545	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.922
AMR76374.1	AMR77543.1	A2G96_00665	A2G96_07210	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.745
AMR76374.1	AMR77593.1	A2G96_00665	A2G96_07495	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hydroxydechloroatrazine ethylaminohydrolase; Catalyzes the transformation of hydroxyatrazine to N-isopropylammelide and ethylamine in the atrazine degradation pathway; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.495
AMR76374.1	AMR79651.1	A2G96_00665	A2G96_18915	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	N-formylglutamate deformylase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.891
AMR76374.1	AMR79652.1	A2G96_00665	A2G96_18920	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formimidoylglutamate deiminase; Catalyzes the deimination of N-formimino-L-glutamate to ammonia and N-formyl-L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.959
AMR76374.1	AMR79995.1	A2G96_00665	A2G96_20720	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.495
AMR76374.1	hutG	A2G96_00665	A2G96_01420	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family.	0.710
AMR76374.1	hutG-2	A2G96_00665	A2G96_04535	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Formimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family.	0.710
AMR76374.1	hutI	A2G96_00665	A2G96_18925	N-formylglutamate amidohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Imidazolonepropionase; Catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.698
AMR76656.1	AMR77123.1	A2G96_02245	A2G96_04855	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.544
AMR76656.1	hutG	A2G96_02245	A2G96_01420	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Formimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family.	0.502
AMR76656.1	hutG-2	A2G96_02245	A2G96_04535	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Formimidoylglutamase; Catalyzes the conversion of N-formimidoyl-L-glutamate to L- glutamate and formamide; Belongs to the arginase family.	0.502
AMR76891.1	AMR78229.1	A2G96_03550	A2G96_10955	Class II glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.555
AMR76891.1	AMR78244.1	A2G96_03550	A2G96_11065	Class II glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Sulfatase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.549
AMR76891.1	AMR79319.1	A2G96_03550	A2G96_17135	Class II glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.555
AMR76891.1	AMR79320.1	A2G96_03550	A2G96_17140	Class II glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Dimethylhistidine N-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.752
AMR77123.1	AMR76656.1	A2G96_04855	A2G96_02245	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.544
AMR77123.1	AMR78455.1	A2G96_04855	A2G96_12310	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.854
AMR77123.1	AMR79962.1	A2G96_04855	A2G96_20550	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	0.752
AMR77123.1	AMR80755.1	A2G96_04855	A2G96_23260	Aldehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family.	Amino acid oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.485

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