STRINGSTRING
OHB45065.1 OHB45065.1 tgt tgt OHB43927.1 OHB43927.1 OHB43941.1 OHB43941.1 OHB43946.1 OHB43946.1 trpS trpS aspS aspS OHB46069.1 OHB46069.1 ruvA ruvA ruvB ruvB OHB46074.1 OHB46074.1 OHB44706.1 OHB44706.1 OHB44708.1 OHB44708.1 OHB44713.1 OHB44713.1 rimO rimO sigA sigA OHB43995.1 OHB43995.1 OHB44003.1 OHB44003.1 OHB44007.1 OHB44007.1 tilS tilS OHB45995.1 OHB45995.1 OHB43899.1 OHB43899.1 OHB43904.1 OHB43904.1 OHB45000.1 OHB45000.1 OHB45001.1 OHB45001.1 lysS lysS tsaD tsaD A2Y13_01680 A2Y13_01680 argS argS tadA tadA OHB45666.1 OHB45666.1 OHB42693.1 OHB42693.1 OHB46029.1 OHB46029.1 OHB45869.1 OHB45869.1 OHB45908.1 OHB45908.1 OHB44062.1 OHB44062.1 OHB44064.1 OHB44064.1 uvrA uvrA OHB45705.1 OHB45705.1 pheT pheT OHB41978.1 OHB41978.1 OHB45728.1 OHB45728.1 xerC xerC uvrB uvrB OHB42539.1 OHB42539.1 OHB42604.1 OHB42604.1 nusB nusB nth nth OHB43350.1 OHB43350.1 A2Y13_03625 A2Y13_03625 OHB45252.1 OHB45252.1 OHB45510.1 OHB45510.1 miaB miaB mnmA mnmA OHB44223.1 OHB44223.1 OHB45353.1 OHB45353.1 OHB45354.1 OHB45354.1 OHB45457.1 OHB45457.1 OHB45101.1 OHB45101.1 OHB42566.1 OHB42566.1 OHB45554.1 OHB45554.1 trmB trmB OHB44595.1 OHB44595.1 OHB44596.1 OHB44596.1 OHB44413.1 OHB44413.1 OHB42646.1 OHB42646.1 dnaA dnaA OHB45941.1 OHB45941.1 OHB45942.1 OHB45942.1 ligA ligA OHB46154.1 OHB46154.1 OHB46155.1 OHB46155.1 ileS ileS OHB44973.1 OHB44973.1 OHB44974.1 OHB44974.1 dnaX dnaX recR recR OHB44977.1 OHB44977.1 csrA csrA cysS cysS ruvC ruvC OHB43813.1 OHB43813.1 OHB43838.1 OHB43838.1 leuS leuS A2Y13_06035 A2Y13_06035 OHB45297.1 OHB45297.1 gyrA gyrA OHB45312.1 OHB45312.1 mnmG mnmG OHB45775.1 OHB45775.1 OHB45802.1 OHB45802.1 OHB45795.1 OHB45795.1 OHB44169.1 OHB44169.1 A2Y13_06700 A2Y13_06700 OHB41867.1 OHB41867.1 OHB41868.1 OHB41868.1 glyQS glyQS OHB45046.1 OHB45046.1 fmt fmt OHB44647.1 OHB44647.1 pheS pheS OHB43291.1 OHB43291.1 OHB45528.1 OHB45528.1 OHB45529.1 OHB45529.1 OHB45534.1 OHB45534.1 mutS mutS rplA rplA nusG nusG OHB44251.1 OHB44251.1 rnr rnr miaA miaA top6A top6A A2Y13_07800 A2Y13_07800 OHB44895.1 OHB44895.1 OHB44896.1 OHB44896.1 rpoB rpoB rpoC rpoC rpsK rpsK rpoA rpoA OHB43783.1 OHB43783.1 OHB43558.1 OHB43558.1 OHB43560.1 OHB43560.1 OHB43564.1 OHB43564.1 smc smc OHB42865.1 OHB42865.1 xerC-2 xerC-2 OHB44423.1 OHB44423.1 nusA nusA rbfA rbfA OHB42707.1 OHB42707.1 serS serS OHB42716.1 OHB42716.1 metG metG gatB gatB A2Y13_08720 A2Y13_08720 pnp pnp rny rny xseA xseA xseB xseB rlmN rlmN thrS thrS dnaA-2 dnaA-2 OHB44113.1 OHB44113.1 gltX gltX OHB45187.1 OHB45187.1 OHB45201.1 OHB45201.1 OHB45208.1 OHB45208.1 ybeY ybeY recO recO OHB44539.1 OHB44539.1 gyrB gyrB alaS alaS recA recA OHB44578.1 OHB44578.1 OHB44581.1 OHB44581.1 hisS hisS mnmE mnmE OHB41799.1 OHB41799.1 rsmH rsmH trmD trmD OHB43204.1 OHB43204.1 OHB43194.1 OHB43194.1 OHB42200.1 OHB42200.1 polA polA topA topA tyrS tyrS OHB42465.1 OHB42465.1 OHB42466.1 OHB42466.1 OHB44474.1 OHB44474.1 OHB43126.1 OHB43126.1 OHB43135.1 OHB43135.1 OHB41716.1 OHB41716.1 OHB41717.1 OHB41717.1 OHB41719.1 OHB41719.1 rnpA rnpA OHB43048.1 OHB43048.1 OHB43468.1 OHB43468.1 OHB43469.1 OHB43469.1 OHB45321.1 OHB45321.1 OHB45339.1 OHB45339.1 OHB44803.1 OHB44803.1 OHB44806.1 OHB44806.1 OHB44807.1 OHB44807.1 OHB43164.1 OHB43164.1 OHB42838.1 OHB42838.1 mfd mfd truA truA A2Y13_11805 A2Y13_11805 valS valS OHB42232.1 OHB42232.1 OHB45586.1 OHB45586.1 OHB45598.1 OHB45598.1 OHB42976.1 OHB42976.1 OHB42978.1 OHB42978.1 OHB42913.1 OHB42913.1 OHB42584.1 OHB42584.1 OHB42586.1 OHB42586.1 OHB46101.1 OHB46101.1 OHB46102.1 OHB46102.1 OHB42346.1 OHB42346.1 OHB41568.1 OHB41568.1 OHB41569.1 OHB41569.1 OHB44758.1 OHB44758.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
OHB45065.1Hypothetical protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (134 aa)
tgttRNA guanosine(34) transglycosylase Tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose t [...] (375 aa)
OHB43927.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GreA/GreB family. (160 aa)
OHB43941.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sigma-70 factor family. ECF subfamily. (166 aa)
OHB43946.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (507 aa)
trpStryptophan--tRNA ligase; Catalyzes the attachment of tryptophan to tRNA(Trp). Belongs to the class-I aminoacyl-tRNA synthetase family. (320 aa)
aspSaspartate--tRNA ligase; Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn); Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. (596 aa)
OHB46069.1TIGR02757 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
ruvAHypothetical protein; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (210 aa)
ruvBHolliday junction DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (346 aa)
OHB46074.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (185 aa)
OHB44706.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (76 aa)
OHB44708.1YicC family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
OHB44713.1Ribonuclease III; Digests double-stranded RNA. (177 aa)
rimORibosomal protein S12 methylthiotransferase RimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (453 aa)
sigARNA polymerase sigma factor RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (574 aa)
OHB43995.1DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Belongs to the DnaG primase family. (548 aa)
OHB44003.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the N(4)/N(6)-methyltransferase family. (260 aa)
OHB44007.1Modification methylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
tilStRNA lysidine(34) synthetase TilS; Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. Belongs to the tRNA(Ile)-lysidine synthase family. (485 aa)
OHB45995.1Hypothetical protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (265 aa)
OHB43899.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (394 aa)
OHB43904.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (265 aa)
OHB45000.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (149 aa)
OHB45001.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (319 aa)
lysSlysine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. (486 aa)
tsaDHypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. (343 aa)
A2Y13_01680Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (1203 aa)
argSarginine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (595 aa)
tadAtRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family. (163 aa)
OHB45666.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily. (211 aa)
OHB42693.1AAA family ATPase; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
OHB46029.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (103 aa)
OHB45869.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 'phage' integrase family. (331 aa)
OHB45908.1tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
OHB44062.1Putative toxin-antitoxin system toxin component, PIN family; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
OHB44064.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 'phage' integrase family. (372 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (945 aa)
OHB45705.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 'phage' integrase family. (291 aa)
pheTphenylalanine--tRNA ligase subunit beta; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily. (671 aa)
OHB41978.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sigma-70 factor family. ECF subfamily. (650 aa)
OHB45728.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (804 aa)
xerCTyrosine recombinase XerC; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (326 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (671 aa)
OHB42539.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (332 aa)
OHB42604.1Hypothetical protein; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (271 aa)
nusBTranscription antitermination factor NusB; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (131 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (222 aa)
OHB43350.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (628 aa)
A2Y13_03625Hypothetical protein; Metagenomic; derived from metagenome: subsurface metagenome. (120 aa)
OHB45252.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sigma-70 factor family. ECF subfamily. (175 aa)
OHB45510.1tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (241 aa)
miaBtRNA (N6-isopentenyl adenosine(37)-C2)-methylthiotransferase MiaB; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (455 aa)
mnmAtRNA 2-thiouridine(34) synthase MnmA; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34. (350 aa)
OHB44223.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (65 aa)
OHB45353.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (563 aa)
OHB45354.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
OHB45457.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (114 aa)
OHB45101.1Putative toxin-antitoxin system toxin component, PIN family; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
OHB42566.1Transposase; Required for the transposition of the insertion element. (411 aa)
OHB45554.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (385 aa)
trmBtRNA (guanosine(46)-N7)-methyltransferase TrmB; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (212 aa)
OHB44595.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (133 aa)
OHB44596.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (179 aa)
OHB44413.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (401 aa)
OHB42646.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (1018 aa)
dnaAHypothetical protein; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (443 aa)
OHB45941.1Resolvase; Derived by automated computational analysis using gene prediction method: Protein Homology. (512 aa)
OHB45942.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
ligADNA ligase (NAD(+)) LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (664 aa)
OHB46154.1Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (431 aa)
OHB46155.1Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1011 aa)
ileSisoleucine--tRNA ligase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily. (946 aa)
OHB44973.1DNA modification methylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the N(4)/N(6)-methyltransferase family. (348 aa)
OHB44974.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (373 aa)
dnaXDNA polymerase III, subunit gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (561 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (201 aa)
OHB44977.1Ribosomal RNA small subunit methyltransferase A; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (293 aa)
csrACarbon storage regulator; A translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Usually binds in the 5'- UTR at or near the Shine-Dalgarno sequence preventing ribosome-binding, thus repressing translation. Its main target seems to be the major flagellin gene, while its function is anatagonized by FliW. (73 aa)
cysScysteine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (492 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (160 aa)
OHB43813.1RNA polymerase subunit sigma-70; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. (264 aa)
OHB43838.1DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (1154 aa)
leuSleucine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-I aminoacyl-tRNA synthetase family. (881 aa)
A2Y13_06035Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing start; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (211 aa)
OHB45297.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial histone-like protein family. (102 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (874 aa)
OHB45312.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 'phage' integrase family. (269 aa)
mnmGtRNA uridine-5-carboxymethylaminomethyl(34) synthesis enzyme MnmG; NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34; Belongs to the MnmG family. (606 aa)
OHB45775.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sigma-70 factor family. ECF subfamily. (184 aa)
OHB45802.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
OHB45795.1Hypothetical protein; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (246 aa)
OHB44169.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (450 aa)
A2Y13_06700tRNA-Gly; Incomplete; too short partial abutting assembly gap; missing stop; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (331 aa)
OHB41867.1Integrase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 'phage' integrase family. (332 aa)
OHB41868.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (92 aa)
glyQSglycine--tRNA ligase; Catalyzes the attachment of glycine to tRNA(Gly). Belongs to the class-II aminoacyl-tRNA synthetase family. (476 aa)
OHB45046.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (502 aa)
fmtmethionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. (318 aa)
OHB44647.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (460 aa)
pheSphenylalanine--tRNA ligase subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily. (329 aa)
OHB43291.1Thiamine biosynthesis protein ThiF; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
OHB45528.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the N(4)/N(6)-methyltransferase family. (267 aa)
OHB45529.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (302 aa)
OHB45534.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (388 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (873 aa)
rplA50S ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. (228 aa)
nusGTranscription termination/antitermination factor NusG; Participates in transcription elongation, termination and antitermination. (182 aa)
OHB44251.1Hypothetical protein; Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines; Belongs to the dus family. (333 aa)
rnrRibonuclease R; 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs. (739 aa)
miaAtRNA (adenosine(37)-N6)-dimethylallyltransferase MiaA; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (307 aa)
top6ADNA topoisomerase VI; Relaxes both positive and negative superturns and exhibits a strong decatenase activity; Belongs to the TOP6A family. (364 aa)
A2Y13_07800Back-translocating Elongation Factor EF4; binds to the ribosome on the universally-conserved alpha-sarcin loop; incomplete; too short partial abutting assembly gap; missing stop; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sigma-70 factor family. ECF subfamily. (179 aa)
OHB44895.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (257 aa)
OHB44896.1glutamine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
rpoBDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1254 aa)
rpoCDNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1423 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (123 aa)
rpoADNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (333 aa)
OHB43783.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (182 aa)
OHB43558.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
OHB43560.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sigma-70 factor family. ECF subfamily. (207 aa)
OHB43564.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (306 aa)
smcChromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1191 aa)
OHB42865.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the pseudouridine synthase RsuA family. (236 aa)
xerC-2Site-specific tyrosine recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. (311 aa)
OHB44423.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (127 aa)
nusAHypothetical protein; Participates in both transcription termination and antitermination. (410 aa)
rbfARibosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (122 aa)
OHB42707.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (226 aa)
serSserine--tRNA ligase; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (423 aa)
OHB42716.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (368 aa)
metGmethionine--tRNA ligase; Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. (675 aa)
gatBglutaminyl-tRNA synthase (glutamine-hydrolyzing) subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily. (486 aa)
A2Y13_08720Hypothetical protein; Incomplete; too short partial abutting assembly gap; missing stop; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (208 aa)
pnpPolyribonucleotide nucleotidyltransferase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (707 aa)
rnyRibonuclease Y; Endoribonuclease that initiates mRNA decay. Belongs to the RNase Y family. (526 aa)
xseAExodeoxyribonuclease VII large subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseA family. (414 aa)
xseBExodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. (68 aa)
rlmN23S rRNA (adenine(2503)-C(2))-methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (344 aa)
thrSHypothetical protein; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). (638 aa)
dnaA-2Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family. (469 aa)
OHB44113.1Hypothetical protein; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (325 aa)
gltXHypothetical protein; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (542 aa)
OHB45187.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (182 aa)
OHB45201.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the N(4)/N(6)-methyltransferase family. (323 aa)
OHB45208.1Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
ybeYrRNA maturation RNase YbeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (164 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (245 aa)
OHB44539.1DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (368 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (809 aa)
alaSalanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain. (891 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (321 aa)
OHB44578.1DNA (cytosine-5-)-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (413 aa)
OHB44581.1Very short patch repair endonuclease; May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. (135 aa)
hisShistidine--tRNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (430 aa)
mnmEtRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE; Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. (467 aa)
OHB41799.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
rsmH16S rRNA (cytosine(1402)-N(4))-methyltransferase; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (360 aa)
trmDtRNA (guanosine(37)-N1)-methyltransferase TrmD; Specifically methylates guanosine-37 in various tRNAs. Belongs to the RNA methyltransferase TrmD family. (231 aa)
OHB43204.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0102 family. (116 aa)
OHB43194.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
OHB42200.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (355 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (918 aa)
topADNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (812 aa)
tyrStyrosine--tRNA ligase; Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two- step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr); Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily. (401 aa)
OHB42465.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (252 aa)
OHB42466.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (815 aa)
OHB44474.1Hypothetical protein; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (314 aa)
OHB43126.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (407 aa)
OHB43135.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sigma-70 factor family. ECF subfamily. (182 aa)
OHB41716.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (401 aa)
OHB41717.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (193 aa)
OHB41719.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (505 aa)
rnpARibonuclease P protein component; RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. (126 aa)
OHB43048.1tRNA epoxyqueuosine(34) reductase QueG; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
OHB43468.1RNA polymerase sigma-54 factor; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (479 aa)
OHB43469.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the sigma-70 factor family. (564 aa)
OHB45321.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (175 aa)
OHB45339.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (146 aa)
OHB44803.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 'phage' integrase family. (367 aa)
OHB44806.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (403 aa)
OHB44807.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)
OHB43164.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (117 aa)
OHB42838.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (442 aa)
mfdHypothetical protein; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1096 aa)
truAtRNA pseudouridine(38-40) synthase TruA; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (247 aa)
A2Y13_11805Hypothetical protein; Metagenomic; derived from metagenome: subsurface metagenome. (328 aa)
valSvaline--tRNA ligase; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily. (898 aa)
OHB42232.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (129 aa)
OHB45586.1DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the bacterial histone-like protein family. (105 aa)
OHB45598.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 'phage' integrase family. (474 aa)
OHB42976.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the 'phage' integrase family. (381 aa)
OHB42978.1Putative toxin-antitoxin system toxin component, PIN family; Derived by automated computational analysis using gene prediction method: Protein Homology. (136 aa)
OHB42913.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
OHB42584.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (578 aa)
OHB42586.1MBL fold metallo-hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
OHB46101.1RNA pseudouridine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (228 aa)
OHB46102.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
OHB42346.1single-stranded-DNA-specific exonuclease RecJ; Derived by automated computational analysis using gene prediction method: Protein Homology. (576 aa)
OHB41568.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (216 aa)
OHB41569.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (233 aa)
OHB44758.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (285 aa)
Your Current Organism:
Planctomycetes bacterium GWC24544
NCBI taxonomy Id: 1801952
Other names: P. bacterium GWC2_45_44, Planctomycetes bacterium GWC2_45_44
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