STRINGSTRING
ANX02814.1 ANX02814.1 ANX05415.1 ANX05415.1 ANX02825.1 ANX02825.1 ANX02826.1 ANX02826.1 ANX02827.1 ANX02827.1 ANX03007.1 ANX03007.1 ANX03054.1 ANX03054.1 eno eno ANX03160.1 ANX03160.1 gpmA gpmA acsA acsA nudF nudF ilvD ilvD rpiA rpiA ANX03300.1 ANX03300.1 tpiA tpiA ANX03370.1 ANX03370.1 ANX03515.1 ANX03515.1 leuA leuA ANX03521.1 ANX03521.1 ANX03522.1 ANX03522.1 ANX03536.1 ANX03536.1 ANX03569.1 ANX03569.1 ANX03592.1 ANX03592.1 ANX03593.1 ANX03593.1 ANX03594.1 ANX03594.1 pdhA pdhA ANX03596.1 ANX03596.1 ANX03653.1 ANX03653.1 ANX05506.1 ANX05506.1 ANX03787.1 ANX03787.1 ANX03788.1 ANX03788.1 ANX03798.1 ANX03798.1 ANX03839.1 ANX03839.1 tal tal ANX03928.1 ANX03928.1 ANX03933.1 ANX03933.1 ANX03934.1 ANX03934.1 prs prs pgi pgi ANX04137.1 ANX04137.1 ANX04138.1 ANX04138.1 ANX04322.1 ANX04322.1 leuB leuB leuD leuD leuC leuC ANX04363.1 ANX04363.1 ANX04366.1 ANX04366.1 ANX04367.1 ANX04367.1 ANX04436.1 ANX04436.1 ANX04437.1 ANX04437.1 ANX04438.1 ANX04438.1 ANX05583.1 ANX05583.1 ANX04634.1 ANX04634.1 fbp fbp ANX04812.1 ANX04812.1 ANX04813.1 ANX04813.1 aceE aceE pckG pckG sucA sucA ANX04910.1 ANX04910.1 ANX04911.1 ANX04911.1 sucC sucC sucD sucD ANX04950.1 ANX04950.1 ANX04951.1 ANX04951.1 fumC fumC ANX05016.1 ANX05016.1 ANX05028.1 ANX05028.1 mdh mdh ilvE ilvE pdhA-2 pdhA-2 ANX05645.1 ANX05645.1 ANX05144.1 ANX05144.1 accA accA ANX05240.1 ANX05240.1 ANX05241.1 ANX05241.1 ANX05243.1 ANX05243.1 pgl pgl zwf zwf edd edd ANX05252.1 ANX05252.1 ANX05654.1 ANX05654.1 gapA gapA pgk pgk ilvC ilvC ANX05397.1 ANX05397.1 ANX05398.1 ANX05398.1 gltA gltA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ANX02814.1Homocitrate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (377 aa)
ANX05415.1NAD-dependent succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (483 aa)
ANX02825.12-oxo acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
ANX02826.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
ANX02827.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (407 aa)
ANX03007.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (790 aa)
ANX03054.1citryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis. (431 aa)
ANX03160.1Pyruvate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (644 aa)
gpmAHypothetical protein; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (231 aa)
acsAAcetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (643 aa)
nudFHypothetical protein; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (611 aa)
rpiARibose-5-phosphate isomerase; Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. (219 aa)
ANX03300.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (377 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (248 aa)
ANX03370.1Fumarate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (583 aa)
ANX03515.1Aconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (899 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (500 aa)
ANX03521.1Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
ANX03522.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (323 aa)
ANX03536.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1153 aa)
ANX03569.1Fructose-bisphosphate aldolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (340 aa)
ANX03592.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (82 aa)
ANX03593.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (447 aa)
ANX03594.1Pyruvate dehydrogenase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (327 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (324 aa)
ANX03596.1acetate--CoA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (584 aa)
ANX03653.1Isocitrate dehydrogenase (NADP(+)); Converts isocitrate to alpha ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
ANX05506.1Citramalate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (529 aa)
ANX03787.1citryl-CoA lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
ANX03788.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (264 aa)
ANX03798.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
ANX03839.1Mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the mannose-6-phosphate isomerase type 2 family. (474 aa)
talHypothetical protein; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (371 aa)
ANX03928.1Phosphoketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (798 aa)
ANX03933.1Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (818 aa)
ANX03934.1Glyceraldehyde-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (352 aa)
prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (317 aa)
pgiHypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the GPI family. (529 aa)
ANX04137.1Ribulose-phosphate 3-epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ribulose-phosphate 3-epimerase family. (223 aa)
ANX04138.1Phosphoglucomutase; Catalyzes the interconversion of alpha-D-mannose 1-phosphate to alpha-D-mannose 6-phosphate and alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (461 aa)
ANX04322.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (379 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (361 aa)
leuD3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (219 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (467 aa)
ANX04363.1Pyruvate kinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
ANX04366.1acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (144 aa)
ANX04367.1acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (447 aa)
ANX04436.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (128 aa)
ANX04437.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (129 aa)
ANX04438.1Succinate dehydrogenase flavoprotein subunit; Part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FAD-depe [...] (601 aa)
ANX05583.1Succinate dehydrogenase iron-sulfur subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. (252 aa)
ANX04634.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the TPP enzyme family. (574 aa)
fbpFructose-bisphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FBPase class 1 family. (332 aa)
ANX04812.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (468 aa)
ANX04813.1Dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (543 aa)
aceEPyruvate dehydrogenase (acetyl-transferring), homodimeric type; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (903 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (584 aa)
sucASucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (943 aa)
ANX04910.1Dihydrolipoamide succinyltransferase; E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2- oxoglutarate to succinyl-CoA and CO(2). (399 aa)
ANX04911.1E3 component of 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; Derived by automated computational analysis using gene prediction method: Protein Homology. (471 aa)
sucCsuccinate--CoA ligase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (389 aa)
sucDsuccinate--CoA ligase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (290 aa)
ANX04950.1Phosphoglucomutase, alpha-D-glucose phosphate-specific; Derived by automated computational analysis using gene prediction method: Protein Homology. (549 aa)
ANX04951.1Phosphoketolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (786 aa)
fumCClass II fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (464 aa)
ANX05016.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (587 aa)
ANX05028.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+; Belongs to the bacterial glucokinase family. (258 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)
ilvEBranched chain amino acid aminotransferase; Acts on leucine, isoleucine and valine. Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (307 aa)
pdhA-2Pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). (355 aa)
ANX05645.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (324 aa)
ANX05144.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
accAacetyl-CoA carboxylase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (319 aa)
ANX05240.12-oxoglutarate ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
ANX05241.1Ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (609 aa)
ANX05243.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (297 aa)
pgl2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. (232 aa)
zwfGlucose-6-phosphate dehydrogenase; Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone. (487 aa)
eddPhosphogluconate dehydratase; Catalyzes the dehydration of 6-phospho-D-gluconate to 2- dehydro-3-deoxy-6-phospho-D-gluconate; Belongs to the IlvD/Edd family. (622 aa)
ANX05252.1Keto-deoxy-phosphogluconate aldolase; Catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology. (206 aa)
ANX05654.1Transketolase; Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate. (665 aa)
gapAType I glyceraldehyde-3-phosphate dehydrogenase; Required for glycolysis; catalyzes the formation of 3-phospho-D-glyceroyl phosphate from D-glyceraldehyde 3-phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
pgkPhosphoglycerate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphoglycerate kinase family. (394 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (338 aa)
ANX05397.1Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (164 aa)
ANX05398.1Acetolactate synthase 3 catalytic subunit; Catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; Derived by automated computational analysis using gene prediction method: Protein Homology. (576 aa)
gltACitrate (Si)-synthase; Type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cit [...] (430 aa)
Your Current Organism:
Immundisolibacter cernigliae
NCBI taxonomy Id: 1810504
Other names: ATCC TSD-58, DSM 103040, Gammaproteobacteria bacterium TR3.2, I. cernigliae, Immundisolibacter cernigliae Corteselli et al. 2017, strain TR3.2
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