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DSM5745_11530 DSM5745_11530 DSM5745_11466 DSM5745_11466 DSM5745_11324 DSM5745_11324 DSM5745_10515 DSM5745_10515 DSM5745_10604 DSM5745_10604 NCS2 NCS2 DSM5745_08619 DSM5745_08619 DSM5745_08927 DSM5745_08927 NCS6 NCS6 DSM5745_08143 DSM5745_08143 NAT10 NAT10 DSM5745_08437 DSM5745_08437 DSM5745_07454 DSM5745_07454 DSM5745_07791 DSM5745_07791 DSM5745_06654 DSM5745_06654 DSM5745_05595 DSM5745_05595 DSM5745_05649 DSM5745_05649 DSM5745_05688 DSM5745_05688 DSM5745_06133 DSM5745_06133 DSM5745_04714 DSM5745_04714 ALA1 ALA1 DSM5745_04311 DSM5745_04311 DSM5745_04197 DSM5745_04197 DSM5745_02758 DSM5745_02758 DSM5745_03375 DSM5745_03375 DSM5745_03471 DSM5745_03471 DSM5745_03769 DSM5745_03769 DSM5745_01685 DSM5745_01685 DSM5745_01754 DSM5745_01754 DSM5745_02107 DSM5745_02107 DSM5745_02362 DSM5745_02362 DSM5745_02360 DSM5745_02360 DSM5745_02540 DSM5745_02540 DSM5745_01196 DSM5745_01196 DSM5745_01133 DSM5745_01133 DSM5745_01464 DSM5745_01464 TRM8 TRM8 DSM5745_01220 DSM5745_01220
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
Your Input:
DSM5745_11530Elongator complex protein 1; Component of the RNA polymerase II elongator complex, a multiprotein complex associated with the RNA polymerase II (Pol II) holoenzyme, and which is involved in transcriptional elongation. Belongs to the ELP1/IKA1 family. (1329 aa)
DSM5745_11466Uncharacterized protein; Belongs to the CGI121/TPRKB family. (198 aa)
DSM5745_11324Tr-type G domain-containing protein. (513 aa)
DSM5745_10515Exportin-T; tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Belongs to the exportin family. (1031 aa)
DSM5745_10604AA_TRNA_LIGASE_II domain-containing protein. (474 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (368 aa)
DSM5745_08619AA_TRNA_LIGASE_II_ALA domain-containing protein. (270 aa)
DSM5745_08927Methyltransf_11 domain-containing protein. (235 aa)
NCS6Cytoplasmic tRNA 2-thiolation protein 1; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (408 aa)
DSM5745_08143AA_TRNA_LIGASE_II domain-containing protein. (498 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1067 aa)
DSM5745_08437Uncharacterized protein. (397 aa)
DSM5745_07454D-aminoacyl-tRNA deacylase. (210 aa)
DSM5745_07791AA_TRNA_LIGASE_II_ALA domain-containing protein. (287 aa)
DSM5745_06654Uncharacterized protein. (398 aa)
DSM5745_05595eIF2 alpha kinase. (1591 aa)
DSM5745_05649Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (575 aa)
DSM5745_05688Uncharacterized protein. (245 aa)
DSM5745_06133tRNA-synt_1c domain-containing protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (509 aa)
DSM5745_04714Lysine--tRNA ligase. (966 aa)
ALA1Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (961 aa)
DSM5745_04311tRNA (guanine(26)-N(2))-dimethyltransferase. (652 aa)
DSM5745_04197Uncharacterized protein. (349 aa)
DSM5745_02758Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (657 aa)
DSM5745_03375tRNA (Guanine(9)-N1)-methyltransferase. (414 aa)
DSM5745_03471AA_TRNA_LIGASE_II domain-containing protein. (488 aa)
DSM5745_03769Uncharacterized protein. (1539 aa)
DSM5745_01685Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family. (1077 aa)
DSM5745_01754SAM_MT_RSMB_NOP domain-containing protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (876 aa)
DSM5745_02107Uncharacterized protein. (516 aa)
DSM5745_02362Threonylcarbamoyl-AMP synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. (428 aa)
DSM5745_02360Uncharacterized protein. (1165 aa)
DSM5745_02540Uncharacterized protein. (770 aa)
DSM5745_01196Uncharacterized protein. (1110 aa)
DSM5745_01133tRNA-binding domain-containing protein. (437 aa)
DSM5745_01464UPF0020 domain-containing protein. (466 aa)
TRM8tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (358 aa)
DSM5745_01220Phenylalanyl-tRNA synthetase. (516 aa)
Your Current Organism:
Aspergillus mulundensis
NCBI taxonomy Id: 1810919
Other names: A. mulundensis, Aspergillus mulundensis Bills and Frisvad, 2015, Aspergillus sp. AJC-2016d, Aspergillus sp. QY-2015, Aspergillus sydowii var. GB-2015, Aspergillus sydowii var. mulundensis, CBS 140610, DSM 5745, DSMZ 5745, DTO 316-C9, IBT 33104
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