STRINGSTRING
DSM5745_11487 DSM5745_11487 DSM5745_10146 DSM5745_10146 DSM5745_10061 DSM5745_10061 DSM5745_06483 DSM5745_06483 DSM5745_05860 DSM5745_05860 DSM5745_04281 DSM5745_04281 DSM5745_02775 DSM5745_02775 DSM5745_02806 DSM5745_02806 DSM5745_03855 DSM5745_03855 DSM5745_03854 DSM5745_03854 DSM5745_01738 DSM5745_01738 DSM5745_01739 DSM5745_01739 DSM5745_00169 DSM5745_00169 DSM5745_01322 DSM5745_01322
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DSM5745_11487Histone-lysine N-methyltransferase, H3 lysine-4 specific; Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation. (1217 aa)
DSM5745_10146Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2890 aa)
DSM5745_10061Uncharacterized protein; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (113 aa)
DSM5745_06483Uncharacterized protein. (527 aa)
DSM5745_05860Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
DSM5745_04281Histone domain-containing protein. (194 aa)
DSM5745_02775Histone H1. (197 aa)
DSM5745_02806CENP-T_C domain-containing protein. (481 aa)
DSM5745_03855Histone H2B; Belongs to the histone H2B family. (140 aa)
DSM5745_03854Histone H2A; Belongs to the histone H2A family. (132 aa)
DSM5745_01738Histone H3; Belongs to the histone H3 family. (136 aa)
DSM5745_01739Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (103 aa)
DSM5745_00169Histone H2A; Belongs to the histone H2A family. (136 aa)
DSM5745_01322Telomerase reverse transcriptase; Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. (1184 aa)
Your Current Organism:
Aspergillus mulundensis
NCBI taxonomy Id: 1810919
Other names: A. mulundensis, Aspergillus mulundensis Bills and Frisvad, 2015, Aspergillus sp. AJC-2016d, Aspergillus sp. QY-2015, Aspergillus sydowii var. GB-2015, Aspergillus sydowii var. mulundensis, CBS 140610, DSM 5745, DSMZ 5745, DTO 316-C9, IBT 33104
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