(98 nodes) mRNA surveillance pathway network (Aspergillus mulundensis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	DSM5745_01621	Uncharacterized protein. (1077 aa)
	DSM5745_03340	Uncharacterized protein. (1635 aa)
	DSM5745_03832	Uncharacterized protein. (550 aa)
	DSM5745_03807	Uncharacterized protein. (363 aa)
	DSM5745_03626	Uncharacterized protein. (913 aa)
	DSM5745_03444	Cleavage and polyadenylation specificity factor subunit 2. (1004 aa)
	DSM5745_02970	mRNA 3'-end-processing protein rna14. (1016 aa)
	DSM5745_03369	Uncharacterized protein. (640 aa)
	DSM5745_03213	Uncharacterized protein. (368 aa)
	DSM5745_03284	PWI domain-containing protein. (737 aa)
	DSM5745_03285	Uncharacterized protein. (96 aa)
	DSM5745_03202	Uncharacterized protein. (369 aa)
	DSM5745_02942	Uncharacterized protein. (517 aa)
	DSM5745_02847	RNA-dependent RNA polymerase. (1442 aa)
	DSM5745_02758	Eukaryotic translation initiation factor 2A; Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl- tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. (657 aa)
	DSM5745_02739	Uncharacterized protein. (860 aa)
	DSM5745_04067	Uncharacterized protein. (1163 aa)
	DSM5745_04183	GAR domain-containing protein. (1058 aa)
	DSM5745_03858	Uncharacterized protein. (186 aa)
	DSM5745_05211	Cytochrome b5 heme-binding domain-containing protein. (628 aa)
	DSM5745_05354	Protein cft1. (1281 aa)
	DSM5745_05310	DUF3453 domain-containing protein. (751 aa)
	DSM5745_05209	Protein phosphatase PP2A regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family. (462 aa)
	DSM5745_04711	Uncharacterized protein. (1048 aa)
	DSM5745_04886	Uncharacterized protein. (239 aa)
	DSM5745_04685	Uncharacterized protein. (541 aa)
	DSM5745_04555	Tr-type G domain-containing protein. (795 aa)
	DSM5745_06026	Pinin_SDK_memA domain-containing protein. (305 aa)
	DSM5745_06025	Uncharacterized protein. (339 aa)
	DSM5745_05870	Putative Pre-mRNA polyadenylation factor fip1. (326 aa)
	DSM5745_05840	Uncharacterized protein. (851 aa)
	DSM5745_05724	Fumarate reductase; Irreversibly catalyzes the reduction of fumarate to succinate. (486 aa)
	DSM5745_05685	Uncharacterized protein. (745 aa)
	DSM5745_05625	Uncharacterized protein. (798 aa)
	DSM5745_05577	Uncharacterized protein. (639 aa)
	DSM5745_05386	Tr-type G domain-containing protein. (707 aa)
	DSM5745_05452	COP9 signalosome complex subunit 5. (335 aa)
	DSM5745_06717	Endoribonuclease ysh1. (880 aa)
	DSM5745_06779	Serine/threonine-protein phosphatase. (329 aa)
	DSM5745_06498	Uncharacterized protein. (512 aa)
	DSM5745_06471	Putative Mago nashi protein. (154 aa)
	DSM5745_06264	RRM domain-containing protein. (233 aa)
	DSM5745_07391	Uncharacterized protein. (556 aa)
	DSM5745_07404	DWNN domain-containing protein. (633 aa)
	DSM5745_07364	mRNA-capping enzyme subunit alpha; Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate; Belongs to the eukaryotic GTase family. (411 aa)
	DSM5745_07076	ATP-dependent RNA helicase dbp5; Belongs to the DEAD box helicase family. (479 aa)
	DSM5745_07197	Interstrand crosslink repair protein. (832 aa)
	DSM5745_07010	RRM domain-containing protein. (299 aa)
	DSM5745_06918	Uncharacterized protein. (388 aa)
	DSM5745_07772	Uncharacterized protein. (442 aa)
	DSM5745_07613	RRM domain-containing protein. (282 aa)
	DSM5745_07625	Uncharacterized protein. (596 aa)
	DSM5745_07482	Goodbye domain-containing protein. (1561 aa)
	DSM5745_08306	mRNA 3'-end-processing protein yth1. (254 aa)
	DSM5745_08029	RRM domain-containing protein. (604 aa)
	DSM5745_11441	Protein DOM34 homolog; May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non- functional ribosomes and degrade damaged mRNAs. (404 aa)
	DSM5745_11470	RRM domain-containing protein. (158 aa)
	DSM5745_11010	FAD_binding_4 domain-containing protein. (471 aa)
	DSM5745_11116	Uncharacterized protein. (833 aa)
	DSM5745_10695	Uncharacterized protein. (780 aa)
	DSM5745_10736	Uncharacterized protein. (1259 aa)
	DSM5745_10464	RNA-dependent RNA polymerase. (1248 aa)
	DSM5745_10588	Peptide chain release factor eRF subunit 1. (497 aa)
	DSM5745_10476	Uncharacterized protein. (669 aa)
	CLP1	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation. (541 aa)
	DSM5745_10116	WD_REPEATS_REGION domain-containing protein. (364 aa)
	DSM5745_10187	FAD_binding_2 domain-containing protein. (589 aa)
	DSM5745_10291	RRM domain-containing protein. (246 aa)
	DSM5745_08962	Uncharacterized protein. (474 aa)
	DSM5745_08706	Putative Zn(II)2Cys6 transcription factor. (975 aa)
	DSM5745_08923	Oxidoreductase, N-terminal. (1035 aa)
	DSM5745_08164	Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. (324 aa)
	DSM5745_01535	Uncharacterized protein. (727 aa)
	DSM5745_01456	Uncharacterized protein. (113 aa)
	DSM5745_00910	Uncharacterized protein. (612 aa)
	DSM5745_01417	Fungal_trans domain-containing protein. (512 aa)
	DSM5745_01253	Serine/threonine-protein phosphatase. (538 aa)
	DSM5745_01233	Uncharacterized protein. (280 aa)
	DSM5745_01172	NTF2 domain-containing protein. (158 aa)
	DSM5745_01076	Mago-bind domain-containing protein. (224 aa)
	DSM5745_00560	Uncharacterized protein. (591 aa)
	DSM5745_00952	Uncharacterized protein. (277 aa)
	DSM5745_00823	Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. (728 aa)
	DSM5745_00885	TYR_PHOSPHATASE_2 domain-containing protein. (662 aa)
	DSM5745_00175	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...] (280 aa)
	DSM5745_00168	Uncharacterized protein. (594 aa)
	DSM5745_00146	Uncharacterized protein; Belongs to the DEAD box helicase family. (399 aa)
	DSM5745_00125	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit; The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. (637 aa)
	DSM5745_02365	RRM domain-containing protein. (295 aa)
	DSM5745_02351	DUF676 domain-containing protein. (1171 aa)
	DSM5745_02292	FAD_binding_2 domain-containing protein. (529 aa)
	DSM5745_02268	WD_REPEATS_REGION domain-containing protein. (592 aa)
	DSM5745_02282	Nuclear cap-binding protein subunit 2. (99 aa)
	DSM5745_01613	Uncharacterized protein. (861 aa)
	DSM5745_01920	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's. (601 aa)
	DSM5745_01858	Uncharacterized protein. (564 aa)
	DSM5745_01680	Uncharacterized protein. (223 aa)
	DSM5745_01607	Uncharacterized protein. (268 aa)

Your Current Organism:

Aspergillus mulundensis

NCBI taxonomy Id: 1810919
Other names: A. mulundensis, Aspergillus mulundensis Bills and Frisvad, 2015, Aspergillus sp. AJC-2016d, Aspergillus sp. QY-2015, Aspergillus sydowii var. GB-2015, Aspergillus sydowii var. mulundensis, CBS 140610, DSM 5745, DSMZ 5745, DTO 316-C9, IBT 33104

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLP1	DSM5745_00168	A0A3D8QMH9	A0A3D8T2Q7	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Uncharacterized protein.	0.901
CLP1	DSM5745_00175	A0A3D8QMH9	A0A3D8T2S5	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]	0.854
CLP1	DSM5745_00560	A0A3D8QMH9	A0A3D8T5F4	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Uncharacterized protein.	0.997
CLP1	DSM5745_01233	A0A3D8QMH9	A0A3D8T652	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Uncharacterized protein.	0.584
CLP1	DSM5745_01920	A0A3D8QMH9	A0A3D8SV30	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.	0.822
CLP1	DSM5745_02268	A0A3D8QMH9	A0A3D8SW14	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	WD_REPEATS_REGION domain-containing protein.	0.796
CLP1	DSM5745_02365	A0A3D8QMH9	A0A3D8SWC0	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	RRM domain-containing protein.	0.985
CLP1	DSM5745_02970	A0A3D8QMH9	A0A3D8SKL8	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	mRNA 3'-end-processing protein rna14.	0.944
CLP1	DSM5745_03202	A0A3D8QMH9	A0A3D8SJR5	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Uncharacterized protein.	0.655
CLP1	DSM5745_03444	A0A3D8QMH9	A0A3D8SKM3	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Cleavage and polyadenylation specificity factor subunit 2.	0.917
CLP1	DSM5745_05310	A0A3D8QMH9	A0A3D8S621	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	DUF3453 domain-containing protein.	0.816
CLP1	DSM5745_05354	A0A3D8QMH9	A0A3D8S656	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Protein cft1.	0.909
CLP1	DSM5745_05870	A0A3D8QMH9	A0A3D8RYC9	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Putative Pre-mRNA polyadenylation factor fip1.	0.960
CLP1	DSM5745_06264	A0A3D8QMH9	A0A3D8RQB0	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	RRM domain-containing protein.	0.680
CLP1	DSM5745_06717	A0A3D8QMH9	A0A3D8RRU4	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Endoribonuclease ysh1.	0.918
CLP1	DSM5745_07010	A0A3D8QMH9	A0A3D8RK82	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	RRM domain-containing protein.	0.703
CLP1	DSM5745_07197	A0A3D8QMH9	A0A3D8RKG6	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Interstrand crosslink repair protein.	0.705
CLP1	DSM5745_07391	A0A3D8QMH9	A0A3D8RL16	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Uncharacterized protein.	0.438
CLP1	DSM5745_07404	A0A3D8QMH9	A0A3D8RKY1	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	DWNN domain-containing protein.	0.438
CLP1	DSM5745_07772	A0A3D8QMH9	A0A3D8RF60	mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.	Uncharacterized protein.	0.672

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