(26 nodes) HDR through Single Strand Annealing (SSA), and Sensing of DNA Double Strand Breaks network (fungal sp. No14919)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A1V1SQD2	Uncharacterized protein. (275 aa)
	A0A1V1SQL1	Uncharacterized protein. (367 aa)
	A0A1V1SRU0	HRDC domain-containing protein. (820 aa)
	A0A1V1SRZ7	BRCT domain-containing protein. (1367 aa)
	A0A1V1SVC7	3'-5' exonuclease domain-containing protein. (560 aa)
	A0A1V1SX68	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (480 aa)
	A0A1V1SXT8	Uncharacterized protein. (766 aa)
	A0A1V1SXV3	DUF1767 domain-containing protein. (257 aa)
	A0A1V1SZ69	Uncharacterized protein. (1001 aa)
	A0A1V1T3D0	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (735 aa)
	A0A1V1T484	Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2449 aa)
	A0A1V1T5N3	AAA_23 domain-containing protein. (1308 aa)
	A0A1V1T8G2	Uncharacterized protein. (98 aa)
	A0A1V1TBS9	Uncharacterized protein. (1153 aa)
	A0A1V1TCE5	Uncharacterized protein. (534 aa)
	A0A1V1TDM7	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily. (348 aa)
	A0A1V1TGX1	RECA_2 domain-containing protein. (404 aa)
	A0A1V1TJX3	Uncharacterized protein. (513 aa)
	A0A1V1TJY7	FHA domain-containing protein. (819 aa)
	A0A1V1TKR0	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (615 aa)
	A0A1V1TKZ0	Uncharacterized protein. (1802 aa)
	A0A1V1TMG1	Uncharacterized protein. (855 aa)
	A0A1V1TMW9	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (660 aa)
	A0A1V1TRY6	RECA_2 domain-containing protein. (579 aa)
	A0A1V1TU42	Uncharacterized protein. (1618 aa)
	A0A1V1TU63	Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (2932 aa)

Your Current Organism:

fungal sp. No14919

NCBI taxonomy Id: 1813822
Other names: f. sp. No.14919, fungal sp. No.14919

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A1V1SQD2	A0A1V1SQL1	Uncharacterized protein.	Uncharacterized protein.	0.883
A0A1V1SQD2	A0A1V1SRU0	Uncharacterized protein.	HRDC domain-containing protein.	0.999
A0A1V1SQD2	A0A1V1SRZ7	Uncharacterized protein.	BRCT domain-containing protein.	0.667
A0A1V1SQD2	A0A1V1SVC7	Uncharacterized protein.	3'-5' exonuclease domain-containing protein.	0.999
A0A1V1SQD2	A0A1V1SX68	Uncharacterized protein.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.875
A0A1V1SQD2	A0A1V1SXT8	Uncharacterized protein.	Uncharacterized protein.	0.856
A0A1V1SQD2	A0A1V1SXV3	Uncharacterized protein.	DUF1767 domain-containing protein.	0.919
A0A1V1SQD2	A0A1V1T3D0	Uncharacterized protein.	Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.	0.820
A0A1V1SQD2	A0A1V1T484	Uncharacterized protein.	Uncharacterized protein; Belongs to the PI3/PI4-kinase family.	0.976
A0A1V1SQD2	A0A1V1T5N3	Uncharacterized protein.	AAA_23 domain-containing protein.	0.665
A0A1V1SQD2	A0A1V1T8G2	Uncharacterized protein.	Uncharacterized protein.	0.875
A0A1V1SQD2	A0A1V1TBS9	Uncharacterized protein.	Uncharacterized protein.	0.825
A0A1V1SQD2	A0A1V1TCE5	Uncharacterized protein.	Uncharacterized protein.	0.982
A0A1V1SQD2	A0A1V1TDM7	Uncharacterized protein.	DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.	0.921
A0A1V1SQD2	A0A1V1TGX1	Uncharacterized protein.	RECA_2 domain-containing protein.	0.807
A0A1V1SQD2	A0A1V1TJX3	Uncharacterized protein.	Uncharacterized protein.	0.985
A0A1V1SQD2	A0A1V1TJY7	Uncharacterized protein.	FHA domain-containing protein.	0.725
A0A1V1SQD2	A0A1V1TKR0	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.998
A0A1V1SQD2	A0A1V1TKZ0	Uncharacterized protein.	Uncharacterized protein.	0.875
A0A1V1SQD2	A0A1V1TMG1	Uncharacterized protein.	Uncharacterized protein.	0.710