(60 nodes) Cellular ketone metabolic process network (Panaeolus cyanescens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CVT24_003195	Uncharacterized protein. (175 aa)
	CVT24_002996	Uncharacterized protein. (410 aa)
	CVT24_009133	Aldo_ket_red domain-containing protein. (303 aa)
	CVT24_007335	VOC domain-containing protein. (202 aa)
	CVT24_012716	Uncharacterized protein. (158 aa)
	CVT24_000688	Uncharacterized protein. (309 aa)
	CVT24_012982	Abhydrolase_3 domain-containing protein. (265 aa)
	BNA4	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid. (517 aa)
	BNA5	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family. (441 aa)
	CVT24_002684	AIG1-type G domain-containing protein. (489 aa)
	CVT24_003653	Uncharacterized protein. (282 aa)
	CVT24_006502	Uncharacterized protein. (907 aa)
	CVT24_001431	Uncharacterized protein. (417 aa)
	CVT24_012144	Uncharacterized protein. (327 aa)
	CVT24_004089	Uncharacterized protein. (211 aa)
	CVT24_003357	Uncharacterized protein. (488 aa)
	CVT24_003601	Aminotran_1_2 domain-containing protein. (432 aa)
	CVT24_009259	DJ-1_PfpI domain-containing protein. (231 aa)
	CVT24_009277	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (462 aa)
	CVT24_004906	Methyltransf_25 domain-containing protein. (267 aa)
	CVT24_000984	Uncharacterized protein. (634 aa)
	CVT24_006355	Aldo_ket_red domain-containing protein. (144 aa)
	CVT24_001844	Uncharacterized protein. (306 aa)
	CVT24_001726	Uncharacterized protein. (514 aa)
	CVT24_001729	Uncharacterized protein. (622 aa)
	CVT24_004316	Uncharacterized protein. (339 aa)
	CVT24_009504	Uncharacterized protein. (119 aa)
	CVT24_008647	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (465 aa)
	CVT24_007857	Uncharacterized protein. (254 aa)
	CVT24_005925	Uncharacterized protein. (329 aa)
	CVT24_009389	Lactamase_B domain-containing protein. (256 aa)
	CVT24_004767	Uncharacterized protein. (228 aa)
	COQ4	Ubiquinone biosynthesis protein COQ4, mitochondrial; Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides; Belongs to the COQ4 family. (305 aa)
	CVT24_008211	Aldo_ket_red domain-containing protein. (308 aa)
	CVT24_011213	NMO domain-containing protein. (320 aa)
	CVT24_000331	Uncharacterized protein. (247 aa)
	CVT24_003159	Ubiquinone biosynthesis protein; Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. (232 aa)
	CVT24_004804	N-acetyltransferase domain-containing protein. (181 aa)
	CVT24_000008	Uncharacterized protein. (564 aa)
	CVT24_000066	Uncharacterized protein; Belongs to the FPP/GGPP synthase family. (475 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (758 aa)
	CVT24_009840	N-acetyltransferase domain-containing protein. (198 aa)
	CVT24_006863	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (261 aa)
	CVT24_001120	Uncharacterized protein. (313 aa)
	CVT24_011159	Aldo_ket_red domain-containing protein. (335 aa)
	CVT24_011458	Uncharacterized protein. (355 aa)
	CVT24_001955	ABC1 domain-containing protein. (638 aa)
	CVT24_002265	2Fe-2S ferredoxin-type domain-containing protein. (213 aa)
	CVT24_012706	DJ-1_PfpI domain-containing protein. (199 aa)
	CVT24_007476	Uncharacterized protein. (444 aa)
	CVT24_012029	DJ-1_PfpI domain-containing protein. (230 aa)
	CVT24_011851	Uncharacterized protein. (163 aa)
	CVT24_007996	NmrA domain-containing protein. (365 aa)
	CVT24_007993	Uncharacterized protein; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (319 aa)
	CVT24_008033	Uncharacterized protein. (274 aa)
	CVT24_002868	DJ-1_PfpI domain-containing protein. (227 aa)
	CVT24_002869	DJ-1_PfpI domain-containing protein. (226 aa)
	CVT24_004167	Uncharacterized protein. (324 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (257 aa)
	CVT24_001492	NADPH:adrenodoxin oxidoreductase, mitochondrial. (498 aa)

Your Current Organism:

Panaeolus cyanescens

NCBI taxonomy Id: 181874
Other names: Copelandia cyanescens, P. cyanescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BNA4	BNA5	A0A409WA77	A0A409WAB0	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	0.992
BNA4	CVT24_000331	A0A409WA77	A0A409VIV8	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.530
BNA4	CVT24_000688	A0A409WA77	A0A409W729	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.541
BNA4	CVT24_001729	A0A409WA77	A0A409YFR9	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.425
BNA4	CVT24_002265	A0A409WA77	A0A409YIE1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	2Fe-2S ferredoxin-type domain-containing protein.	0.466
BNA4	CVT24_003357	A0A409WA77	A0A409Y798	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.425
BNA4	CVT24_003601	A0A409WA77	A0A409Y7Z1	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Aminotran_1_2 domain-containing protein.	0.947
BNA4	CVT24_004767	A0A409WA77	A0A409VEH8	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.541
BNA4	CVT24_004906	A0A409WA77	A0A409YB33	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Methyltransf_25 domain-containing protein.	0.541
BNA4	CVT24_007335	A0A409WA77	A0A409W580	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	VOC domain-containing protein.	0.400
BNA4	CVT24_007857	A0A409WA77	A0A409VCF2	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.541
BNA4	CVT24_008033	A0A409WA77	A0A409YR05	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Uncharacterized protein.	0.541
BNA4	CVT24_012982	A0A409WA77	A0A409WA72	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	Abhydrolase_3 domain-containing protein.	0.446
BNA5	BNA4	A0A409WAB0	A0A409WA77	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.	0.992
BNA5	COQ6	A0A409WAB0	A0A409VT70	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.628
BNA5	CVT24_000331	A0A409WAB0	A0A409VIV8	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.984
BNA5	CVT24_001726	A0A409WAB0	A0A409YFR7	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.728
BNA5	CVT24_001729	A0A409WAB0	A0A409YFR9	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.947
BNA5	CVT24_003357	A0A409WAB0	A0A409Y798	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Uncharacterized protein.	0.946
BNA5	CVT24_003601	A0A409WAB0	A0A409Y7Z1	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively; Belongs to the kynureninase family.	Aminotran_1_2 domain-containing protein.	0.944