(45 nodes) Ubiquinone and other terpenoid-quinone biosynthesis network (Panaeolus cyanescens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

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textmining

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protein homology

Your Input:
	CVT24_011851	Uncharacterized protein. (163 aa)
	CVT24_011882	Uncharacterized protein. (67 aa)
	CVT24_010338	Flavodoxin-like domain-containing protein. (212 aa)
	CVT24_008033	Uncharacterized protein. (274 aa)
	CVT24_000893	Uncharacterized protein. (316 aa)
	CVT24_005678	AB hydrolase-1 domain-containing protein. (321 aa)
	CVT24_009489	Aminotran_1_2 domain-containing protein. (526 aa)
	CVT24_007857	Uncharacterized protein. (254 aa)
	CVT24_005797	4HBT domain-containing protein. (190 aa)
	CVT24_004767	Uncharacterized protein. (228 aa)
	CVT24_008209	Uncharacterized protein. (612 aa)
	CVT24_010809	Uncharacterized protein. (198 aa)
	CVT24_012113	FAD_binding_3 domain-containing protein. (555 aa)
	CVT24_011994	Uncharacterized protein. (575 aa)
	CVT24_011258	Uncharacterized protein. (248 aa)
	CVT24_000152	4HBT domain-containing protein. (190 aa)
	CVT24_007305	Uncharacterized protein. (634 aa)
	CVT24_007120	FAD_binding_3 domain-containing protein. (565 aa)
	CVT24_008710	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate. (263 aa)
	CVT24_002954	DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (250 aa)
	CVT24_001670	Uncharacterized protein. (572 aa)
	COQ6	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6. (758 aa)
	CVT24_003181	Flavodoxin-like domain-containing protein. (278 aa)
	CVT24_000056	4HBT domain-containing protein. (188 aa)
	CVT24_001055	Uncharacterized protein. (1647 aa)
	COQ7	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. (257 aa)
	CVT24_008585	Uncharacterized protein. (578 aa)
	CVT24_000688	Uncharacterized protein. (309 aa)
	CVT24_010065	FAD_binding_3 domain-containing protein. (577 aa)
	CVT24_010117	FAD_binding_3 domain-containing protein. (578 aa)
	CVT24_003653	Uncharacterized protein. (282 aa)
	CVT24_012144	Uncharacterized protein. (327 aa)
	CVT24_004089	Uncharacterized protein. (211 aa)
	CVT24_004906	Methyltransf_25 domain-containing protein. (267 aa)
	CVT24_005017	Flavodoxin-like domain-containing protein. (203 aa)
	CVT24_001844	Uncharacterized protein. (306 aa)
	CVT24_011458	Uncharacterized protein. (355 aa)
	CVT24_012436	Uncharacterized protein. (582 aa)
	CVT24_007476	Uncharacterized protein. (444 aa)
	CVT24_011878	Uncharacterized protein. (94 aa)
	CVT24_004167	Uncharacterized protein. (324 aa)
	CVT24_006549	4HBT domain-containing protein. (220 aa)
	CVT24_003195	Uncharacterized protein. (175 aa)
	CVT24_002996	Uncharacterized protein. (410 aa)
	CVT24_012128	4HBT domain-containing protein. (161 aa)

Your Current Organism:

Panaeolus cyanescens

NCBI taxonomy Id: 181874
Other names: Copelandia cyanescens, P. cyanescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
COQ6	COQ7	A0A409VT70	A0A409W1T8	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	0.908
COQ6	CVT24_000688	A0A409VT70	A0A409W729	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	Uncharacterized protein.	0.938
COQ6	CVT24_000893	A0A409VT70	A0A409YTD8	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	Uncharacterized protein.	0.531
COQ6	CVT24_004767	A0A409VT70	A0A409VEH8	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	Uncharacterized protein.	0.596
COQ6	CVT24_004906	A0A409VT70	A0A409YB33	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	Methyltransf_25 domain-containing protein.	0.596
COQ6	CVT24_007857	A0A409VT70	A0A409VCF2	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	Uncharacterized protein.	0.953
COQ6	CVT24_008033	A0A409VT70	A0A409YR05	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	Uncharacterized protein.	0.596
COQ6	CVT24_008710	A0A409VT70	A0A409VKI5	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	4-hydroxybenzoate polyprenyltransferase, mitochondrial; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.	0.666
COQ6	CVT24_011258	A0A409VT70	A0A409VI73	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	Uncharacterized protein.	0.661
COQ7	COQ6	A0A409W1T8	A0A409VT70	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.908
COQ7	CVT24_000688	A0A409W1T8	A0A409W729	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	Uncharacterized protein.	0.914
COQ7	CVT24_004767	A0A409W1T8	A0A409VEH8	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	Uncharacterized protein.	0.767
COQ7	CVT24_004906	A0A409W1T8	A0A409YB33	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	Methyltransf_25 domain-containing protein.	0.767
COQ7	CVT24_007120	A0A409W1T8	A0A409VK18	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	FAD_binding_3 domain-containing protein.	0.429
COQ7	CVT24_007857	A0A409W1T8	A0A409VCF2	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	Uncharacterized protein.	0.914
COQ7	CVT24_008033	A0A409W1T8	A0A409YR05	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	Uncharacterized protein.	0.767
COQ7	CVT24_010065	A0A409W1T8	A0A409W9E2	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	FAD_binding_3 domain-containing protein.	0.429
COQ7	CVT24_010117	A0A409W1T8	A0A409W9M3	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	FAD_binding_3 domain-containing protein.	0.429
COQ7	CVT24_012113	A0A409W1T8	A0A409VHI6	5-demethoxyubiquinone hydroxylase, mitochondrial; Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6- methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.	FAD_binding_3 domain-containing protein.	0.429
CVT24_000688	COQ6	A0A409W729	A0A409VT70	Uncharacterized protein.	Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial; FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl- 4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.	0.938