(42 nodes) Histidine metabolism network (Panaeolus cyanescens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	CVT24_004187	Uncharacterized protein. (438 aa)
	CVT24_007417	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (500 aa)
	CVT24_007414	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (492 aa)
	CVT24_013100	Uncharacterized protein. (245 aa)
	CVT24_010571	Uncharacterized protein. (199 aa)
	CVT24_010718	Uncharacterized protein. (558 aa)
	CVT24_011006	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (503 aa)
	CVT24_011289	Uncharacterized protein. (445 aa)
	CVT24_013053	Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily. (316 aa)
	CVT24_002513	Aminotran_5 domain-containing protein. (594 aa)
	CVT24_010609	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (494 aa)
	CVT24_000510	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family. (554 aa)
	CVT24_008331	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (503 aa)
	CVT24_006190	Phosphatase tensin-type domain-containing protein. (1339 aa)
	CVT24_003224	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (531 aa)
	CVT24_011248	N2227 domain-containing protein. (382 aa)
	CVT24_005043	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (420 aa)
	CVT24_013004	Uncharacterized protein. (644 aa)
	CVT24_001074	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (523 aa)
	CVT24_006456	Uncharacterized protein. (378 aa)
	CVT24_006457	Uncharacterized protein. (422 aa)
	CVT24_001178	Uncharacterized protein. (335 aa)
	CVT24_010620	AB hydrolase-1 domain-containing protein. (496 aa)
	CVT24_007413	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (502 aa)
	CVT24_001281	Uncharacterized protein. (464 aa)
	CVT24_012502	Uncharacterized protein. (1024 aa)
	CVT24_011429	Uncharacterized protein. (405 aa)
	CVT24_011171	Uncharacterized protein. (452 aa)
	CVT24_011167	Uncharacterized protein. (562 aa)
	CVT24_011168	Uncharacterized protein. (517 aa)
	CVT24_001299	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. (474 aa)
	CVT24_005503	Uncharacterized protein. (235 aa)
	CVT24_004502	Uncharacterized protein. (864 aa)
	CVT24_008970	N2227 domain-containing protein. (414 aa)
	CVT24_009608	Uncharacterized protein. (547 aa)
	CVT24_004017	Histidine biosynthesis trifunctional protein. (845 aa)
	CVT24_004030	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. (288 aa)
	CVT24_002558	Uncharacterized protein. (256 aa)
	CVT24_002623	Uncharacterized protein. (936 aa)
	CVT24_010143	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (504 aa)
	CVT24_010064	Uncharacterized protein. (490 aa)
	CVT24_004186	Uncharacterized protein. (476 aa)

Your Current Organism:

Panaeolus cyanescens

NCBI taxonomy Id: 181874
Other names: Copelandia cyanescens, P. cyanescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT24_000510	CVT24_001178	A0A409V8E8	A0A409W2U6	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.992
CVT24_000510	CVT24_001281	A0A409V8E8	A0A409YZ28	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.991
CVT24_000510	CVT24_004017	A0A409V8E8	A0A409Y669	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Histidine biosynthesis trifunctional protein.	0.997
CVT24_000510	CVT24_004030	A0A409V8E8	A0A409Y6E8	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.	0.996
CVT24_000510	CVT24_010571	A0A409V8E8	A0A409YYL2	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.997
CVT24_000510	CVT24_012502	A0A409V8E8	A0A409YK10	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Uncharacterized protein.	0.967
CVT24_000510	CVT24_013053	A0A409V8E8	A0A409YUQ2	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily.	0.604
CVT24_001074	CVT24_003224	A0A409VX31	A0A409VFV2	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.621
CVT24_001074	CVT24_007417	A0A409VX31	A0A409YKY4	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.404
CVT24_001074	CVT24_008331	A0A409VX31	A0A409VCA8	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.404
CVT24_001074	CVT24_013100	A0A409VX31	A0A409YN48	Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family.	Uncharacterized protein.	0.427
CVT24_001178	CVT24_000510	A0A409W2U6	A0A409V8E8	Uncharacterized protein.	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	0.992
CVT24_001178	CVT24_001281	A0A409W2U6	A0A409YZ28	Uncharacterized protein.	Uncharacterized protein.	0.981
CVT24_001178	CVT24_004017	A0A409W2U6	A0A409Y669	Uncharacterized protein.	Histidine biosynthesis trifunctional protein.	0.998
CVT24_001178	CVT24_004030	A0A409W2U6	A0A409Y6E8	Uncharacterized protein.	1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase.	0.989
CVT24_001178	CVT24_010571	A0A409W2U6	A0A409YYL2	Uncharacterized protein.	Uncharacterized protein.	0.980
CVT24_001178	CVT24_012502	A0A409W2U6	A0A409YK10	Uncharacterized protein.	Uncharacterized protein.	0.973
CVT24_001178	CVT24_013053	A0A409W2U6	A0A409YUQ2	Uncharacterized protein.	Histidinol-phosphatase; Belongs to the PHP hydrolase family. HisK subfamily.	0.560
CVT24_001281	CVT24_000510	A0A409YZ28	A0A409V8E8	Uncharacterized protein.	Imidazole glycerol phosphate synthase hisHF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain. Belongs to the HisA/HisF family.	0.991
CVT24_001281	CVT24_001178	A0A409YZ28	A0A409W2U6	Uncharacterized protein.	Uncharacterized protein.	0.981