(44 nodes) Propanoate metabolism network (Panaeolus cyanescens)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CVT24_004272	Uncharacterized protein. (839 aa)
	CVT24_007903	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex. (495 aa)
	CVT24_004752	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (433 aa)
	CVT24_005977	Uncharacterized protein. (343 aa)
	CVT24_000437	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (523 aa)
	CVT24_008873	Epimerase domain-containing protein. (344 aa)
	CVT24_003025	Acetyl-coenzyme A synthetase. (660 aa)
	CVT24_008224	Uncharacterized protein. (377 aa)
	CVT24_006844	PKS_ER domain-containing protein. (438 aa)
	CVT24_010947	Uncharacterized protein. (434 aa)
	CVT24_005592	Uncharacterized protein. (561 aa)
	CVT24_001306	Uncharacterized protein; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (328 aa)
	CVT24_003011	Uncharacterized protein. (568 aa)
	CVT24_007178	Uncharacterized protein. (296 aa)
	CVT24_011513	Transket_pyr domain-containing protein. (421 aa)
	CVT24_007677	3Beta_HSD domain-containing protein. (328 aa)
	CVT24_001483	Uncharacterized protein. (2234 aa)
	CVT24_003673	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family. (676 aa)
	CVT24_009853	SET domain-containing protein. (433 aa)
	CVT24_004886	Uncharacterized protein. (167 aa)
	CVT24_000195	Dihydrolipoyl dehydrogenase. (502 aa)
	CVT24_001630	Epimerase domain-containing protein. (356 aa)
	CVT24_010104	Epimerase domain-containing protein. (355 aa)
	CVT24_003850	Uncharacterized protein. (338 aa)
	CVT24_007942	Uncharacterized protein. (443 aa)
	CVT24_006486	Thiolase_C domain-containing protein. (132 aa)
	CVT24_007789	Thiolase_C domain-containing protein. (132 aa)
	CVT24_004127	YCII domain-containing protein; Belongs to the enoyl-CoA hydratase/isomerase family. (442 aa)
	CVT24_003369	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family. (499 aa)
	CVT24_003376	Uncharacterized protein. (1213 aa)
	CVT24_009327	MaoC-like domain-containing protein. (855 aa)
	CVT24_003634	Uncharacterized protein. (1589 aa)
	CVT24_005242	Uncharacterized protein. (482 aa)
	CVT24_005971	Uncharacterized protein. (344 aa)
	CVT24_008325	Thiolase_N domain-containing protein. (211 aa)
	CVT24_008869	Epimerase domain-containing protein. (342 aa)
	CVT24_010328	Probable acetate kinase. (446 aa)
	CVT24_005973	Uncharacterized protein. (777 aa)
	CVT24_006083	Aldedh domain-containing protein. (544 aa)
	CVT24_009167	Uncharacterized protein. (365 aa)
	CVT24_009661	Uncharacterized protein. (333 aa)
	CVT24_011365	Uncharacterized protein. (151 aa)
	CVT24_002319	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). (441 aa)
	CVT24_007093	CoA carboxyltransferase C-terminal domain-containing protein. (604 aa)

Your Current Organism:

Panaeolus cyanescens

NCBI taxonomy Id: 181874
Other names: Copelandia cyanescens, P. cyanescens

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CVT24_000195	CVT24_000437	A0A409W327	A0A409V8A7	Dihydrolipoyl dehydrogenase.	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	0.922
CVT24_000195	CVT24_002319	A0A409W327	A0A409YII8	Dihydrolipoyl dehydrogenase.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.989
CVT24_000195	CVT24_003011	A0A409W327	A0A409VFU9	Dihydrolipoyl dehydrogenase.	Uncharacterized protein.	0.581
CVT24_000195	CVT24_003025	A0A409W327	A0A409VFP4	Dihydrolipoyl dehydrogenase.	Acetyl-coenzyme A synthetase.	0.507
CVT24_000195	CVT24_003369	A0A409W327	A0A409Y6X3	Dihydrolipoyl dehydrogenase.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.404
CVT24_000195	CVT24_003673	A0A409W327	A0A409VUP4	Dihydrolipoyl dehydrogenase.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.596
CVT24_000195	CVT24_004752	A0A409W327	A0A409V9T0	Dihydrolipoyl dehydrogenase.	Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.969
CVT24_000195	CVT24_004886	A0A409W327	A0A409W258	Dihydrolipoyl dehydrogenase.	Uncharacterized protein.	0.596
CVT24_000195	CVT24_005592	A0A409W327	A0A409YXU3	Dihydrolipoyl dehydrogenase.	Uncharacterized protein.	0.557
CVT24_000195	CVT24_007903	A0A409W327	A0A409YQJ2	Dihydrolipoyl dehydrogenase.	Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex.	0.997
CVT24_000195	CVT24_011513	A0A409W327	A0A409VMK8	Dihydrolipoyl dehydrogenase.	Transket_pyr domain-containing protein.	0.994
CVT24_000437	CVT24_000195	A0A409V8A7	A0A409W327	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Dihydrolipoyl dehydrogenase.	0.922
CVT24_000437	CVT24_001483	A0A409V8A7	A0A409VT93	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Uncharacterized protein.	0.882
CVT24_000437	CVT24_002319	A0A409V8A7	A0A409YII8	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	2-oxoisovalerate dehydrogenase subunit alpha; The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3).	0.652
CVT24_000437	CVT24_003011	A0A409V8A7	A0A409VFU9	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Uncharacterized protein.	0.630
CVT24_000437	CVT24_003025	A0A409V8A7	A0A409VFP4	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Acetyl-coenzyme A synthetase.	0.927
CVT24_000437	CVT24_003369	A0A409V8A7	A0A409Y6X3	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial; Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite; Belongs to the enoyl-CoA hydratase/isomerase family.	0.548
CVT24_000437	CVT24_003673	A0A409V8A7	A0A409VUP4	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Acyl-coenzyme A oxidase; Belongs to the acyl-CoA oxidase family.	0.632
CVT24_000437	CVT24_003850	A0A409V8A7	A0A409WNA7	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	Uncharacterized protein.	0.627
CVT24_000437	CVT24_004127	A0A409V8A7	A0A409Y678	Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.	YCII domain-containing protein; Belongs to the enoyl-CoA hydratase/isomerase family.	0.686