STRINGSTRING
AKE00301.1 AKE00301.1 AKD95406.1 AKD95406.1 gltD gltD AKD95641.1 AKD95641.1 AKD95659.1 AKD95659.1 fdxA_2 fdxA_2 whiB4 whiB4 nth nth AKD95946.1 AKD95946.1 kshA_2 kshA_2 AKE00412.1 AKE00412.1 AKD96128.1 AKD96128.1 AKD96244.1 AKD96244.1 AKD96404.1 AKD96404.1 whiB whiB AKD96464.1 AKD96464.1 AKD96502.1 AKD96502.1 AKD96674.1 AKD96674.1 AKE00534.1 AKE00534.1 mftB mftB albA albA whiB3 whiB3 AKD96998.1 AKD96998.1 AKE00565.1 AKE00565.1 AKD97051.1 AKD97051.1 whiB-2 whiB-2 AKD97155.1 AKD97155.1 rshA rshA whiB1 whiB1 AKD97177.1 AKD97177.1 AKD97178.1 AKD97178.1 whiB-3 whiB-3 moaA moaA AKD97271.1 AKD97271.1 ilvD ilvD leuC leuC rlmN rlmN ispG ispG AKD97375.1 AKD97375.1 AKE00641.1 AKE00641.1 AKD97443.1 AKD97443.1 nuoI nuoI nuoH nuoH AKD97499.1 AKD97499.1 AKD97500.1 AKD97500.1 AKD97501.1 AKD97501.1 nqo6_2 nqo6_2 miaB miaB AKD97674.1 AKD97674.1 iscU iscU AKD97759.1 AKD97759.1 acnA acnA gltD-2 gltD-2 AKD98003.1 AKD98003.1 AKE00726.1 AKE00726.1 nadA nadA bioB bioB AKD98175.1 AKD98175.1 erpA erpA lipA_2 lipA_2 AKD98294.1 AKD98294.1 AKD98296.1 AKD98296.1 cysH cysH AKD98349.1 AKD98349.1 AKD98386.1 AKD98386.1 AKD98532.1 AKD98532.1 ylxH ylxH fdxA_1 fdxA_1 fbiC fbiC AKE00839.1 AKE00839.1 AKE00842.1 AKE00842.1 ispH ispH whiB3_2 whiB3_2 AKD99079.1 AKD99079.1 AKD99139.1 AKD99139.1 purF purF AKD99390.1 AKD99390.1 ilvD_1 ilvD_1 AKD99476.1 AKD99476.1 AKD99505.1 AKD99505.1 AKD99627.1 AKD99627.1 AKD99628.1 AKD99628.1 AKD99732.1 AKD99732.1 AKD99851.1 AKD99851.1 AKD99858.1 AKD99858.1 AKD99862.1 AKD99862.1 AKE01013.1 AKE01013.1 AKD99936.1 AKD99936.1 AKE00003.1 AKE00003.1 AKE00122.1 AKE00122.1 AKE00184.1 AKE00184.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKE00301.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (373 aa)
AKD95406.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1532 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
AKD95641.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (64 aa)
AKD95659.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
fdxA_2(4Fe-4S)-binding protein; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (106 aa)
whiB4Transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (107 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (261 aa)
AKD95946.1Adenine glycosylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (293 aa)
kshA_23-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
AKE00412.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa)
AKD96128.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
AKD96244.1Cobalamin; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
AKD96404.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (79 aa)
whiBTranscription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (103 aa)
AKD96464.1Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1064 aa)
AKD96502.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
AKD96674.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (189 aa)
AKE00534.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (351 aa)
mftBMycofactocin system protein MftB; Derived by automated computational analysis using gene prediction method: Protein Homology. (95 aa)
albARadical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
whiB3WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (98 aa)
AKD96998.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (256 aa)
AKE00565.1Reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. NasA/NapA/NarB subfamily. (1394 aa)
AKD97051.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
whiB-2Hypothetical protein; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (130 aa)
AKD97155.1stearoyl-CoA 9-desaturase; Derived by automated computational analysis using gene prediction method: Protein Homology. (372 aa)
rshAAnti-sigma factor; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
whiB1WhiB family transcriptional regulator; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (84 aa)
AKD97177.1Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (833 aa)
AKD97178.1Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (137 aa)
whiB-3Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (107 aa)
moaAMolybdenum cofactor biosynthesis protein MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (352 aa)
AKD97271.1Cysteine desulfurase; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (613 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (473 aa)
rlmNRibosomal RNA large subunit methyltransferase N; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (369 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (385 aa)
AKD97375.1Serine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the iron-sulfur dependent L-serine dehydratase family. (452 aa)
AKE00641.1Hydrogenase expression protein HypE; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
AKD97443.1Nitrogen fixation protein NifU; Derived by automated computational analysis using gene prediction method: Protein Homology. (300 aa)
nuoINADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (195 aa)
nuoHNADH:ubiquinone oxidoreductase subunit H; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. (456 aa)
AKD97499.1NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. Belongs to the complex I 75 kDa subunit family. (805 aa)
AKD97500.1NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Belongs to the complex I 51 kDa subunit family. (439 aa)
AKD97501.1NADH dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (274 aa)
nqo6_2NADH dehydrogenase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
miaB(dimethylallyl)adenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (515 aa)
AKD97674.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (345 aa)
iscUNitrogen fixation protein NifU; Derived by automated computational analysis using gene prediction method: Protein Homology. (167 aa)
AKD97759.1Metal-sulfur cluster biosynthetic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (933 aa)
gltD-2Glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (500 aa)
AKD98003.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1492 aa)
AKE00726.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (63 aa)
nadAQuinolinate synthetase; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (345 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (337 aa)
AKD98175.1Menaquinol-cytochrome C reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
erpAIron-sulfur cluster insertion protein ErpA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HesB/IscA family. (116 aa)
lipA_2Radical SAM protein; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (336 aa)
AKD98294.1Coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (408 aa)
AKD98296.1Sulfite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (576 aa)
cysHPhosphoadenosine phosphosulfate reductase; Reduction of activated sulfate into sulfite. Belongs to the PAPS reductase family. CysH subfamily. (247 aa)
AKD98349.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (781 aa)
AKD98386.1Ferredoxin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
AKD98532.14Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (107 aa)
ylxHSodium:proton antiporter; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (378 aa)
fdxA_1Ferredoxin; Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. (107 aa)
fbiCFO synthase; 7,8-didemethyl-8-hydroxy-5-deazariboflavin synthase; catalyzes radical-mediated transfer of hydroxybenzyl group from 4-hydroxyphenylpyruvate (HPP) to 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione to form 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO); functions in F420 biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (852 aa)
AKE00839.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (565 aa)
AKE00842.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (525 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (337 aa)
whiB3_2Transcription factor WhiB; Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA. (105 aa)
AKD99079.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (363 aa)
AKD99139.1Indolepyruvate ferredoxin oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1151 aa)
purFAmidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (525 aa)
AKD99390.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (560 aa)
ilvD_1Dihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (564 aa)
AKD99476.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
AKD99505.13-ketosteroid-9-alpha-hydroxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (387 aa)
AKD99627.1(4Fe-4S) protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (506 aa)
AKD99628.1Fe-S osidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
AKD99732.1Rrf2 family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
AKD99851.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
AKD99858.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (149 aa)
AKD99862.1Phenylacetic acid degradation protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AKE01013.1Phenylacetic acid degradation protein PaaD; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
AKD99936.14Fe-4S ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (575 aa)
AKE00003.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
AKE00122.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (378 aa)
AKE00184.1Ferredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (214 aa)
Your Current Organism:
Rhodococcus erythropolis
NCBI taxonomy Id: 1833
Other names: ATCC 4277, Arthrobacter hydrocarboglutamicus, Arthrobacter oxamicetus, Arthrobacter oxamicetus subsp. propiophenicolus, Arthrobacter paraffineus, Arthrobacter picolinophilus, Brevibacterium healii, Brevibacterium ketoglutamicum, Brevibacterium paraffinoliticum, CIP 104179, Corynebacterium alkanum, Corynebacterium aurantiacum, Corynebacterium humiferum, Corynebacterium sp. WS2071, Corynebacterium sp. WS2072, DSM 43066, IEGM 7, IFO 15567, JCM 20419, JCM 3201, LMG 5359, LMG:5359, Mycobacterium erythropolis, NBRC 15567, NCIB 11148, NCIB 9158, NCIB:11148, NCIB:9158, NCIMB 9158, NCTC 13021, NRRL B-16025, Nocardia calcarea, Nocardioides simplex ATCC 13260, Nocardioides simplex ATCC 19565, Nocardioides simplex ATCC 19566, R. erythropolis, Rhodococcus NI86/21, Rhodococcus sp. (strain NI86/21), Rhodococcus sp. ATCC 15108, Rhodococcus sp. ATCC 15961, Rhodococcus sp. ATCC 21035, Rhodococcus sp. BG43, Rhodococcus sp. BZ4, Rhodococcus sp. NCIB 9646, Rhodococcus sp. NI86/21, Rhodococcus sp. strain NI86/21, VKM Ac-858, strain N11
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