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ANU71374.1 ANU71374.1 aroQ aroQ A4V01_00530 A4V01_00530 ANU67527.1 ANU67527.1 ANU67662.1 ANU67662.1 ANU67708.1 ANU67708.1 ANU67709.1 ANU67709.1 ANU67728.1 ANU67728.1 aroC aroC ANU67730.1 ANU67730.1 aroA aroA ANU67732.1 ANU67732.1 ANU71395.1 ANU71395.1 ANU67921.1 ANU67921.1 ANU67923.1 ANU67923.1 dapH dapH dapB dapB dapA dapA dapF dapF ANU68104.1 ANU68104.1 lysA lysA ANU68106.1 ANU68106.1 ANU68304.1 ANU68304.1 ANU68585.1 ANU68585.1 ANU68640.2 ANU68640.2 ANU68648.1 ANU68648.1 ANU68658.1 ANU68658.1 hisZ hisZ hisG hisG hisD hisD ANU68744.1 ANU68744.1 hisB hisB hisH hisH hisA hisA hisF hisF hisI hisI hisE hisE ANU68900.1 ANU68900.1 ANU68904.1 ANU68904.1 fumC fumC ANU68940.1 ANU68940.1 ANU68942.1 ANU68942.1 ANU68981.1 ANU68981.1 ANU69156.1 ANU69156.1 asnA asnA ANU69214.1 ANU69214.1 ANU69252.1 ANU69252.1 ANU69351.1 ANU69351.1 ANU69352.1 ANU69352.1 ANU69353.1 ANU69353.1 ilvC ilvC ilvD ilvD ANU69425.1 ANU69425.1 aspA aspA ANU69495.1 ANU69495.1 ANU69544.1 ANU69544.1 ANU69586.1 ANU69586.1 ANU69623.1 ANU69623.1 aroK aroK aroE aroE aroD aroD argD argD argB argB argJ argJ argC argC argH argH argG argG leuB leuB leuD leuD leuC leuC leuA leuA ANU70456.1 ANU70456.1 ANU70457.1 ANU70457.1 ANU70458.1 ANU70458.1 ANU70624.1 ANU70624.1 ANU70705.1 ANU70705.1 serC serC A4V01_18185 A4V01_18185 ANU70726.1 ANU70726.1 ANU71514.2 ANU71514.2 ANU70727.1 ANU70727.1 ANU70875.1 ANU70875.1 thrB thrB ANU70877.1 ANU70877.1 ANU70878.1 ANU70878.1 ANU70879.1 ANU70879.1 asd asd A4V01_20170 A4V01_20170 trpD trpD trpC trpC trpF trpF trpB trpB trpA trpA ANU71083.1 ANU71083.1 ANU71355.1 ANU71355.1
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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ANU71374.1Rep protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
aroQAAA family ATPase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (156 aa)
A4V01_00530Hypothetical protein; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
ANU67527.1Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology. (573 aa)
ANU67662.1GNAT family N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (250 aa)
ANU67708.1Aspartate/aromatic aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (411 aa)
ANU67709.1Bifunctional chorismate mutase/prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
ANU67728.13-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (337 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa)
ANU67730.13-deoxy-7-phosphoheptulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (420 aa)
ANU67732.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (282 aa)
ANU71395.1Histidinol phosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. (265 aa)
ANU67921.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (310 aa)
ANU67923.14-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
dapH2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. (230 aa)
dapB4-hydroxy-tetrahydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (239 aa)
dapA4-hydroxy-tetrahydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (293 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (273 aa)
ANU68104.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (399 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (457 aa)
ANU68106.1Peptidase M20; Derived by automated computational analysis using gene prediction method: Protein Homology. (369 aa)
ANU68304.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (308 aa)
ANU68585.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (342 aa)
ANU68640.2Histidinol phosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. (257 aa)
ANU68648.1Asparagine synthase (glutamine-hydrolyzing); Derived by automated computational analysis using gene prediction method: Protein Homology. (611 aa)
ANU68658.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (242 aa)
hisZATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. (374 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. (210 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (427 aa)
ANU68744.1Histidinol-phosphate transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (344 aa)
hisBImidazoleglycerol-phosphate dehydratase; Catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (203 aa)
hisHImidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (207 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
hisFImidazole glycerol phosphate synthase cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (253 aa)
hisIphosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (108 aa)
hisEphosphoribosyl-ATP diphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (107 aa)
ANU68900.1L-asparaginase 1; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
ANU68904.1NAD-dependent malic enzyme; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
fumCFumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (454 aa)
ANU68940.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (566 aa)
ANU68942.1Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (399 aa)
ANU68981.1Histidinol phosphate phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. (260 aa)
ANU69156.1Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (355 aa)
asnAAspartate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
ANU69214.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
ANU69252.1Peroxiredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology. (154 aa)
ANU69351.1Threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. (400 aa)
ANU69352.1Acetolactate synthase, large subunit, biosynthetic type; Derived by automated computational analysis using gene prediction method: Protein Homology. (556 aa)
ANU69353.1Acetolactate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. (163 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (331 aa)
ilvDDihydroxy-acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (554 aa)
ANU69425.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
aspAAspartate ammonia-lyase; Catalyzes the formation of fumarate from aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. (477 aa)
ANU69495.1Asparagine synthetase B; Derived by automated computational analysis using gene prediction method: Protein Homology. (526 aa)
ANU69544.1Lactate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (326 aa)
ANU69586.1Dipeptidase PepV; Derived by automated computational analysis using gene prediction method: Protein Homology. (463 aa)
ANU69623.13-deoxy-7-phosphoheptulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (338 aa)
aroKShikimate dehydrogenase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (421 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (290 aa)
aroD3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (253 aa)
argDAspartate aminotransferase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (389 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (290 aa)
argJBifunctional ornithine acetyltransferase/N-acetylglutamate synthase; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (405 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (346 aa)
argHArgininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (464 aa)
argGArgininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (407 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. (359 aa)
leuD3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (164 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (421 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (564 aa)
ANU70456.1Isocitrate dehydrogenase; Catalyzes the formation of 2-oxoglutarate from isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
ANU70457.1Citrate synthase; Catalyzes the formation of citrate from acetyl-CoA and oxaloacetate; Derived by automated computational analysis using gene prediction method: Protein Homology. (444 aa)
ANU70458.1Aconitate hydratase; Catalyzes the conversion of citrate to isocitrate; Derived by automated computational analysis using gene prediction method: Protein Homology. (640 aa)
ANU70624.1N-acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (155 aa)
ANU70705.13-phosphoglycerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (388 aa)
serC3-phosphoserine/phosphohydroxythreonine aminotransferase; Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine. (361 aa)
A4V01_18185Hypothetical protein; Incomplete; partial on complete genome; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
ANU70726.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (290 aa)
ANU71514.2Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (381 aa)
ANU70727.1D-amino-acid transaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (296 aa)
ANU70875.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0735 family. (144 aa)
thrBHomoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily. (293 aa)
ANU70877.1Threonine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
ANU70878.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
ANU70879.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (436 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (341 aa)
A4V01_20170Anthranilate synthase component I; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
trpDAnthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (339 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (255 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (201 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (394 aa)
trpATryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (264 aa)
ANU71083.1Histidinol phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PHP hydrolase family. HisK subfamily. (266 aa)
ANU71355.1Dipeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (453 aa)
Your Current Organism:
Erysipelotrichaceae bacterium I46
NCBI taxonomy Id: 1834207
Other names: E. bacterium I46
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