STRINGSTRING
pmvk pmvk LOC111670130 LOC111670130 ENSSLDP00000033199 ENSSLDP00000033199 mbtps2 mbtps2 r3hdm4 r3hdm4 mvk mvk srebf2 srebf2 ldlr ldlr LOC111666903 LOC111666903 LOC111660199 LOC111660199 srebf1 srebf1 LOC111664553 LOC111664553 pcsk9 pcsk9 LOC111659632 LOC111659632 cln8 cln8 LOC111670516 LOC111670516 insig1 insig1 LOC111670550 LOC111670550 ch25h ch25h npc1 npc1 LOC111665754 LOC111665754 npc2 npc2 LOC111653346 LOC111653346 idh1 idh1 HSD17B7 HSD17B7 LOC111672420 LOC111672420 LOC111667407 LOC111667407 mvd mvd lbr lbr tm7sf2 tm7sf2 scarb1 scarb1 cdcp2 cdcp2 ENSSLDP00000022795 ENSSLDP00000022795 idh3b idh3b apob apob erlin1 erlin1 vldlr vldlr LOC111657606 LOC111657606 fdps fdps rusc1 rusc1 gba gba smpd1 smpd1 prkaa1 prkaa1 lss lss LOC111654496 LOC111654496 LOC111652162 LOC111652162 LOC111656250 LOC111656250 LOC111648008 LOC111648008 LOC111658753 LOC111658753 LOC111666108 LOC111666108 ENSSLDP00000017884 ENSSLDP00000017884 LOC111650147 LOC111650147 cetp cetp LOC111666845 LOC111666845 scap scap mbtps1 mbtps1 dhcr7 dhcr7 ldlrap1 ldlrap1 NPC1L1 NPC1L1 star star LOC111648405 LOC111648405 hmgcr hmgcr LOC111670549 LOC111670549 sqle sqle nsdhl nsdhl cubn cubn LOC111648541 LOC111648541 LOC111670824 LOC111670824 LOC111653799 LOC111653799 apoa4 apoa4 idi1 idi1 ENSSLDP00000009747 ENSSLDP00000009747 LOC111649950 LOC111649950 dhcr24 dhcr24 LOC111661080 LOC111661080 LOC111670231 LOC111670231 LOC111650214 LOC111650214 LOC111653771 LOC111653771 arv1 arv1 gba2 gba2 LOC111671423 LOC111671423 hdlbp hdlbp tmem130 tmem130 LOC111667688 LOC111667688 LOC111667756 LOC111667756 LOC111659144 LOC111659144 ebp ebp LOC111672518 LOC111672518 ENSSLDP00000004142 ENSSLDP00000004142 sc5d sc5d LOC111648965 LOC111648965 lepr lepr LOC111644225 LOC111644225 LOC111644168 LOC111644168 LOC111651125 LOC111651125 LOC111651129 LOC111651129 LOC111651132 LOC111651132 angptl3 angptl3 fdft1 fdft1 insig2 insig2 LOC111645381 LOC111645381 ENSSLDP00000001578 ENSSLDP00000001578 ENSSLDP00000001516 ENSSLDP00000001516 LOC111661577 LOC111661577 ENSSLDP00000001389 ENSSLDP00000001389 ENSSLDP00000001343 ENSSLDP00000001343 disp3 disp3 idh2 idh2 lipe lipe LOC111652406 LOC111652406 LOC111667050 LOC111667050 ENSSLDP00000000228 ENSSLDP00000000228 LOC111667029 LOC111667029 apof apof
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
pmvkPhosphomevalonate kinase. (199 aa)
LOC111670130CLN6 transmembrane ER protein a. (304 aa)
ENSSLDP00000033199Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (264 aa)
mbtps2Membrane-bound transcription factor peptidase, site 2. (499 aa)
r3hdm4R3H domain containing 4. (256 aa)
mvkMevalonate kinase. (366 aa)
srebf2Sterol regulatory element binding transcription factor 2. (1176 aa)
ldlrLow density lipoprotein receptor a. (912 aa)
LOC111666903Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (581 aa)
LOC111660199START domain-containing protein. (222 aa)
srebf1Sterol regulatory element binding transcription factor 1. (1198 aa)
LOC111664553Low density lipoprotein receptor b. (879 aa)
pcsk9Proprotein convertase subtilisin/kexin type 9; Belongs to the peptidase S8 family. (729 aa)
LOC1116596323-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (515 aa)
cln8CLN8 transmembrane ER and ERGIC protein. (288 aa)
LOC111670516Fibrinogen C-terminal domain-containing protein. (526 aa)
insig1Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (276 aa)
LOC111670550Uncharacterized protein. (904 aa)
ch25hCholesterol 25-hydroxylase; Belongs to the sterol desaturase family. (258 aa)
npc1Niemann-Pick disease, type C1. (1257 aa)
LOC111665754High density lipoprotein binding protein b. (1263 aa)
npc2Niemann-Pick disease, type C2. (160 aa)
LOC111653346Uncharacterized protein. (161 aa)
idh1Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (411 aa)
HSD17B7Hydroxysteroid 17-beta dehydrogenase 7. (340 aa)
LOC111672420Si:ch211-113j14.1; Belongs to the cytochrome P450 family. (554 aa)
LOC111667407Cytochrome P450, family 27, subfamily A, polypeptide 7; Belongs to the cytochrome P450 family. (514 aa)
mvdDiphosphomevalonate decarboxylase; Performs the first committed step in the biosynthesis of isoprenes. (402 aa)
lbrLamin B receptor. (622 aa)
tm7sf2Transmembrane 7 superfamily member 2. (425 aa)
scarb1Scavenger receptor class B, member 1; Belongs to the CD36 family. (491 aa)
cdcp2CUB domain containing protein 2. (390 aa)
ENSSLDP00000022795CUB domain-containing protein. (150 aa)
idh3bIsocitrate dehydrogenase [NAD] subunit, mitochondrial. (386 aa)
apobApolipoprotein Ba. (3969 aa)
erlin1ER lipid raft associated 1. (338 aa)
vldlrVery low density lipoprotein receptor. (864 aa)
LOC111657606Cytochrome P450, family 51; Belongs to the cytochrome P450 family. (666 aa)
fdpsUncharacterized protein; Belongs to the FPP/GGPP synthase family. (358 aa)
rusc1Uncharacterized protein. (1622 aa)
gbaGlucosylceramidase. (522 aa)
smpd1Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide. (602 aa)
prkaa1Non-specific serine/threonine protein kinase. (573 aa)
lssTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (735 aa)
LOC111654496Cytochrome P450, family 2, subfamily R, polypeptide 1; Belongs to the cytochrome P450 family. (519 aa)
LOC111652162Cytochrome P450, family 11, subfamily C, polypeptide 1; Belongs to the cytochrome P450 family. (552 aa)
LOC111656250LIM zinc-binding domain-containing protein. (385 aa)
LOC111648008ER lipid raft associated 2. (332 aa)
LOC111658753Lecithin-cholesterol acyltransferase. (434 aa)
LOC111666108Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (285 aa)
ENSSLDP00000017884Cholesterol 25-hydroxylase like 2; Belongs to the sterol desaturase family. (285 aa)
LOC111650147Zgc:92275. (447 aa)
cetpCholesteryl ester transfer protein; Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL; Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. (502 aa)
LOC1116668453-hydroxy-3-methylglutaryl coenzyme A reductase. (883 aa)
scapSREBF chaperone. (1274 aa)
mbtps1Membrane-bound transcription factor peptidase, site 1. (1125 aa)
dhcr77-dehydrocholesterol reductase. (478 aa)
ldlrap1Low density lipoprotein receptor adaptor protein 1b. (312 aa)
NPC1L1NPC1 like intracellular cholesterol transporter 1. (1358 aa)
starSteroidogenic acute regulatory protein, mitochondrial; Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. (286 aa)
LOC111648405Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
hmgcr3-hydroxy-3-methylglutaryl coenzyme A reductase. (844 aa)
LOC111670549Phosphomevalonate kinase. (139 aa)
sqleSqualene epoxidase a. (572 aa)
nsdhlNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (380 aa)
cubnCubilin (intrinsic factor-cobalamin receptor). (3594 aa)
LOC111648541LIM zinc-binding domain-containing protein. (117 aa)
LOC111670824Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (392 aa)
LOC111653799Si:dkey-91i10.3; Belongs to the cytochrome P450 family. (546 aa)
apoa4Apolipoprotein A-Ib. (285 aa)
idi1Isopentenyl-diphosphate delta isomerase 1. (288 aa)
ENSSLDP00000009747Uncharacterized protein. (162 aa)
LOC111649950Non-specific serine/threonine protein kinase. (556 aa)
dhcr2424-dehydrocholesterol reductase. (516 aa)
LOC111661080Lipase, hormone-sensitive a. (697 aa)
LOC111670231Cytochrome P450, family 7, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (499 aa)
LOC111650214Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (296 aa)
LOC111653771Hydroxysteroid (17-beta) dehydrogenase 7. (336 aa)
arv1ARV1 homolog, fatty acid homeostasis modulator. (240 aa)
gba2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (899 aa)
LOC111671423Low density lipoprotein receptor adaptor protein 1a. (281 aa)
hdlbpHigh density lipoprotein binding protein a. (1275 aa)
tmem130Transmembrane protein 130. (314 aa)
LOC111667688Cytochrome P450, family 27, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (511 aa)
LOC111667756LIM zinc-binding domain-containing protein. (729 aa)
LOC111659144Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (453 aa)
ebpEBP cholestenol delta-isomerase. (232 aa)
LOC111672518Cytochrome P450, family 46, subfamily A, polypeptide 1, tandem duplicate 4. (507 aa)
ENSSLDP00000004142LIM zinc-binding domain-containing protein. (1262 aa)
sc5dSterol-C5-desaturase; Belongs to the sterol desaturase family. (302 aa)
LOC111648965Uncharacterized protein. (259 aa)
leprLeptin receptor. (1180 aa)
LOC111644225LIM domain and actin binding 1a. (734 aa)
LOC111644168Isocitrate dehydrogenase [NAD] subunit, mitochondrial. (358 aa)
LOC111651125Apolipoprotein Eb. (276 aa)
LOC111651129Uncharacterized protein. (255 aa)
LOC111651132Uncharacterized protein. (255 aa)
angptl3Angiopoietin-like 3. (473 aa)
fdft1Farnesyl-diphosphate farnesyltransferase 1. (451 aa)
insig2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (235 aa)
LOC111645381Low density lipoprotein receptor-related protein 8, apolipoprotein e receptor. (938 aa)
ENSSLDP00000001578Vitellogenin domain-containing protein. (414 aa)
ENSSLDP00000001516Uncharacterized protein. (2718 aa)
LOC111661577Vitellogenin domain-containing protein. (3338 aa)
ENSSLDP00000001389Vitellogenin domain-containing protein. (390 aa)
ENSSLDP00000001343Uncharacterized protein. (405 aa)
disp3Dispatched RND transporter family member 3. (1311 aa)
idh2Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (452 aa)
lipeLipase, hormone-sensitive b. (837 aa)
LOC111652406Uncharacterized protein. (309 aa)
LOC111667050Cholesterol 25-hydroxylase like 1, tandem duplicate 1; Belongs to the sterol desaturase family. (277 aa)
ENSSLDP00000000228Uncharacterized protein. (237 aa)
LOC111667029Cholesterol 25-hydroxylase like 1, tandem duplicate 2; Belongs to the sterol desaturase family. (276 aa)
apofApolipoprotein F. (443 aa)
Your Current Organism:
Seriola lalandi
NCBI taxonomy Id: 1841481
Other names: S. lalandi dorsalis, Seriola dorsalis, Seriola lalandi dorsalis
Server load: low (16%) [HD]