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APG27766.1 APG27766.1 APG27789.1 APG27789.1 A7E78_08320 A7E78_08320 fabH-2 fabH-2 acpP-2 acpP-2 gpsA gpsA ispD ispD ispF ispF glmU glmU APG28470.1 APG28470.1 APG28554.1 APG28554.1 lipA lipA APG28561.1 APG28561.1 A7E78_12615 A7E78_12615 ispG ispG APG29137.1 APG29137.1 APG28738.1 APG28738.1 APG28749.1 APG28749.1 APG28817.1 APG28817.1 murG murG APG28930.1 APG28930.1 APG28931.1 APG28931.1 APG28938.1 APG28938.1 APG26412.1 APG26412.1 APG26434.1 APG26434.1 APG26443.1 APG26443.1 APG26445.1 APG26445.1 APG26475.1 APG26475.1 ispE ispE APG26550.1 APG26550.1 APG28957.1 APG28957.1 kdsB kdsB kdsA kdsA APG26602.1 APG26602.1 lpxD lpxD fabZ fabZ lpxA lpxA lpxB lpxB APG26630.1 APG26630.1 lpxK lpxK APG28965.1 APG28965.1 APG26632.1 APG26632.1 APG26637.1 APG26637.1 APG26638.1 APG26638.1 APG26647.1 APG26647.1 APG26662.1 APG26662.1 APG28971.1 APG28971.1 plsX plsX fabH fabH APG26708.1 APG26708.1 APG26709.1 APG26709.1 acpP acpP APG26711.1 APG26711.1 pckG pckG APG26840.1 APG26840.1 APG26851.1 APG26851.1 dxs dxs APG26888.1 APG26888.1 APG29004.1 APG29004.1 APG26935.1 APG26935.1 APG26937.1 APG26937.1 APG26962.1 APG26962.1 APG26982.1 APG26982.1 ispH ispH APG27122.1 APG27122.1 APG27233.1 APG27233.1 psd psd dxr dxr APG29025.1 APG29025.1 APG27257.1 APG27257.1 accA accA APG27354.1 APG27354.1 APG27358.1 APG27358.1 acpS acpS APG27486.1 APG27486.1 APG27488.1 APG27488.1 APG27503.1 APG27503.1 APG27504.1 APG27504.1 lpxC lpxC APG27635.1 APG27635.1 accD accD plsY plsY APG27749.1 APG27749.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
APG27766.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
APG27789.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (452 aa)
A7E78_08320Hypothetical protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (289 aa)
fabH-2F0F1 ATP synthase subunit beta; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (329 aa)
acpP-2Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (101 aa)
gpsAGlycerol-3-phosphate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (334 aa)
ispD2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (233 aa)
ispF2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (160 aa)
glmUUDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (460 aa)
APG28470.1Oleate hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
APG28554.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (292 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (289 aa)
APG28561.1Isoprenoid biosynthesis protein ElbB; Derived by automated computational analysis using gene prediction method: Protein Homology. (220 aa)
A7E78_12615Voltage-gated chloride channel protein; Frameshifted; Derived by automated computational analysis using gene prediction method: Protein Homology. (519 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (360 aa)
APG29137.1Phosphatidylserine decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the phosphatidylserine decarboxylase family. (335 aa)
APG28738.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
APG28749.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
APG28817.1Phosphatidylglycerophosphatase A; Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG). (157 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (360 aa)
APG28930.1acetyl-CoA carboxylase, biotin carboxyl carrier protein; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (154 aa)
APG28931.1acetyl-CoA carboxylase biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (445 aa)
APG28938.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (290 aa)
APG26412.1acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
APG26434.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (502 aa)
APG26443.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (219 aa)
APG26445.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (375 aa)
APG26475.1enoyl-ACP reductase; Catalyzes a key regulatory step in fatty acid biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
ispE4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (287 aa)
APG26550.1Octaprenyl diphosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (321 aa)
APG28957.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (235 aa)
kdsB3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (252 aa)
kdsA3-deoxy-8-phosphooctulonate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the KdsA family. (277 aa)
APG26602.1Phenylphosphate carboxylase subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology. (175 aa)
lpxDUDP-3-O-(3-hydroxymyristoyl)glucosamine N-acyltransferase; Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3- hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. Belongs to the transferase hexapeptide repeat family. LpxD subfamily. (343 aa)
fabZ3-hydroxyacyl-[acyl-carrier-protein] dehydratase FabZ; Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. (147 aa)
lpxAacyl-[acyl-carrier-protein]--UDP-N- acetylglucosamine O-acyltransferase; Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (256 aa)
lpxBlipid-A-disaccharide synthase; Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. (382 aa)
APG26630.1Hypothetical protein; Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP- Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A; Belongs to the glycosyltransferase group 1 family. (431 aa)
lpxKTetraacyldisaccharide 4'-kinase; Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). (360 aa)
APG28965.1Lipopolysaccharide heptosyltransferase II; Derived by automated computational analysis using gene prediction method: Protein Homology. (330 aa)
APG26632.1Lipopolysaccharide heptosyltransferase I; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
APG26637.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (495 aa)
APG26638.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (527 aa)
APG26647.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (263 aa)
APG26662.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (430 aa)
APG28971.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (181 aa)
plsXPhosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (339 aa)
fabH3-oxoacyl-ACP synthase; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids; Belongs to the thiolase-like superfamily. FabH family. (326 aa)
APG26708.1Malonyl CoA-acyl carrier protein transacylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (306 aa)
APG26709.13-oxoacyl-[acyl-carrier-protein] reductase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (245 aa)
acpPAcyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa)
APG26711.1Beta-ketoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. (410 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (622 aa)
APG26840.1CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (195 aa)
APG26851.1Polyprenyl synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the FPP/GGPP synthase family. (296 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (634 aa)
APG26888.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
APG29004.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (725 aa)
APG26935.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (85 aa)
APG26937.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (361 aa)
APG26962.1NUDIX hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (177 aa)
APG26982.1Glycosyl transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (311 aa)
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (279 aa)
APG27122.1acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (140 aa)
APG27233.1CDP-diacylglycerol--serine O-phosphatidyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (252 aa)
psdPhosphatidylserine decarboxylase; Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). (214 aa)
dxr1-deoxy-D-xylulose-5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (385 aa)
APG29025.1Di-trans,poly-cis-decaprenylcistransferase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (240 aa)
APG27257.1Diacylglycerol kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (232 aa)
accAacetyl-CoA carboxylase carboxyltransferase subunit alpha; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa)
APG27354.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
APG27358.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (831 aa)
acpSHolo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (129 aa)
APG27486.1acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
APG27488.1butyryl-CoA:acetate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (445 aa)
APG27503.1acyl-CoA thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
APG27504.1acetyl-CoA acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the thiolase-like superfamily. Thiolase family. (393 aa)
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Catalyzes the hydrolysis of UDP-3-O-myristoyl-N- acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis; Belongs to the LpxC family. (308 aa)
APG27635.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (290 aa)
accDacetyl-CoA carboxylase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (282 aa)
plsYAcyl-phosphate glycerol 3-phosphate acyltransferase; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (195 aa)
APG27749.1Acyl-glycerolphosphate acyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (235 aa)
Your Current Organism:
Pelobacter sp. SFB93
NCBI taxonomy Id: 1842532
Other names: P. sp. SFB93
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