STRINGSTRING
BSY17_964 BSY17_964 pcaF pcaF AOF95491.1 AOF95491.1 gmk gmk AOF96674.1 AOF96674.1 thiL thiL AOF96111.1 AOF96111.1 AOF98209.1 AOF98209.1 BSY17_122 BSY17_122 AOF95763.1 AOF95763.1 adk adk coaE coaE AOF98213.1 AOF98213.1 BSY17_145 BSY17_145 BSY17_148 BSY17_148 coaX coaX AOF95556.1 AOF95556.1 AOF98470.1 AOF98470.1 AOF96507.1 AOF96507.1 AOF96767.1 AOF96767.1 prs prs AOF96438.1 AOF96438.1 AOF95596.1 AOF95596.1 AOF95819.1 AOF95819.1 BSY17_176 BSY17_176 pgk pgk gap gap tkt tkt BSY17_191 BSY17_191 AOF96870.1 AOF96870.1 BSY17_981 BSY17_981 argB argB ppk1 ppk1 AOF96355.1 AOF96355.1 ndk ndk pgi pgi AOF97948.1 AOF97948.1 AOF96585.1 AOF96585.1 AOF95914.1 AOF95914.1 AOF95736.1 AOF95736.1 AOF97240.1 AOF97240.1 AOF96621.1 AOF96621.1 AOF97294.1 AOF97294.1 AOF98279.1 AOF98279.1 sucA sucA nnrE nnrE AOF96288.1 AOF96288.1 ispE ispE proB proB thrB thrB pyrH pyrH aroK aroK glk glk AOF95841.1 AOF95841.1 AOF96826.1 AOF96826.1 AOF96722.1 AOF96722.1 AOF97952.1 AOF97952.1 AOF97651.1 AOF97651.1 AOF96008.1 AOF96008.1 AOF96825.1 AOF96825.1 prsK prsK BSY17_257 BSY17_257 BSY17_263 BSY17_263 folK folK AOF96672.1 AOF96672.1 thiD thiD tpiA tpiA AOF98268.1 AOF98268.1 AOF96703.1 AOF96703.1 AOF97616.1 AOF97616.1 AOF96558.1 AOF96558.1 AOF97772.1 AOF97772.1 ppdK ppdK AOF98243.1 AOF98243.1 lpdA-2 lpdA-2 AOF95756.1 AOF95756.1 AOF96688.1 AOF96688.1 tmk tmk AOF97462.1 AOF97462.1 AOF96100.1 AOF96100.1 cmk cmk BSY17_328 BSY17_328 tdk tdk ribF ribF gpmA gpmA BSY17_388 BSY17_388 BSY17_395 BSY17_395 pdhA pdhA eno eno anmK anmK BSY17_436 BSY17_436 BSY17_439 BSY17_439 BSY17_478 BSY17_478 nadK nadK BSY17_556 BSY17_556 BSY17_558 BSY17_558 BSY17_560 BSY17_560 cysC cysC pyk pyk ptsP ptsP BSY17_742 BSY17_742 BSY17_756 BSY17_756 BSY17_757 BSY17_757 BSY17_759 BSY17_759 BSY17_865 BSY17_865 BSY17_892 BSY17_892 BSY17_911 BSY17_911
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
BSY17_964AAA domain protein; [R] COG4240 Predicted kinase. (298 aa)
pcaFpcaF: 3-oxoadipyl-CoA thiolase; [I] COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (400 aa)
AOF95491.1Stringent starvation B family protein; [S] COG3814 Uncharacterized protein conserved in bacteria. (158 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (221 aa)
AOF96674.1Sensory box protein; [T] COG0642 Signal transduction histidine kinase. (807 aa)
thiLThiamine-phosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (304 aa)
AOF96111.1ACT domain protein; [E] COG0527 Aspartokinases. (480 aa)
AOF98209.1Conserved hypothetical protein; [S] COG3205 Predicted membrane protein. (78 aa)
BSY17_122[T] COG0642 Signal transduction histidine kinase. (571 aa)
AOF95763.1Polyphosphate kinase 2 family protein; [S] COG2326 Uncharacterized conserved protein. (263 aa)
adkAdenylate kinase family protein; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (218 aa)
coaEdephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (197 aa)
AOF98213.1Kinase/pyrophosphorylase family protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (275 aa)
BSY17_145Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein; [T] COG0642 Signal transduction histidine kinase. (457 aa)
BSY17_148Hypothetical protein. (104 aa)
coaXPantothenate kinase, type III family protein; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (259 aa)
AOF95556.1FIST N domain protein; [S] COG3287 Uncharacterized conserved protein. (386 aa)
AOF98470.1Sensory box protein; [T] COG0642 Signal transduction histidine kinase. (749 aa)
AOF96507.1Cobinamide kinase / cobinamide phosphate guanyltransferase family protein; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (183 aa)
AOF96767.1Histidine phosphatase super family protein; [G] COG0406 Fructose-2,6-bisphosphatase. (189 aa)
prsRibose-phosphate diphosphokinase family protein; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (311 aa)
AOF96438.1pfkB carbohydrate kinase family protein; [G] COG0524 Sugar kinases, ribokinase family. (333 aa)
AOF95596.1GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (935 aa)
AOF95819.1Hypothetical protein. (164 aa)
BSY17_176Fructose-bisphosphate aldolase class-I family protein; [G] COG3588 Fructose-1,6-bisphosphate aldolase. (301 aa)
pgk[G] COG0126 3-phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (400 aa)
gapGAPDH-I: glyceraldehyde-3-phosphate dehydrogenase, type I; [G] COG0057 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (336 aa)
tktTransketolase; Tktlase_bact: transketolase; [G] COG0021 Transketolase; Belongs to the transketolase family. (655 aa)
BSY17_191Dehydrogenase E1 component family protein; [C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (432 aa)
AOF96870.1Sensory box protein; [T] COG2202 FOG: PAS/PAC domain. (508 aa)
BSY17_981HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (467 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (305 aa)
ppk1Polyphosphate kinase 1; Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). Belongs to the polyphosphate kinase 1 (PPK1) family. (712 aa)
AOF96355.1Trm112p-like family protein; [S] COG2835 Uncharacterized conserved protein; Belongs to the UPF0434 family. (60 aa)
ndkNucleoside diphosphate kinase family protein; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
pgiPhosphoglucose isomerase family protein; [G] COG0166 Glucose-6-phosphate isomerase; Belongs to the GPI family. (501 aa)
AOF97948.1Sensory box protein; [T] COG0642 Signal transduction histidine kinase. (428 aa)
AOF96585.1Putative hpr(Ser) kinase/phosphatase. (287 aa)
AOF95914.1Diacylglycerol kinase catalytic domain protein. (322 aa)
AOF95736.1Diacylglycerol kinase catalytic domain protein; [IR] COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase. (306 aa)
AOF97240.1cheW-like domain protein; [NT] COG0643 Chemotaxis protein histidine kinase and related kinases. (793 aa)
AOF96621.1Histidine kinase family protein; [T] COG2972 Predicted signal transduction protein with a C-terminal ATPase domain. (368 aa)
AOF97294.1HIT domain protein; [FGR] COG0537 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases. (146 aa)
AOF98279.1HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (438 aa)
sucA2oxo_dh_E1: oxoglutarate dehydrogenase (succinyl-transferring), E1 component; [C] COG0567 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes. (931 aa)
nnrEyjeF-related family protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of b [...] (460 aa)
AOF96288.1[T] COG0642 Signal transduction histidine kinase. (663 aa)
ispE4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (293 aa)
proBGlutamate 5-kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (376 aa)
thrBthrB_alt: homoserine kinase; [R] COG2334 Putative homoserine kinase type II (protein kinase fold); Belongs to the pseudomonas-type ThrB family. (325 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (241 aa)
aroKAAA domain protein; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (197 aa)
glkGlk: glucokinase; [G] COG0837 Glucokinase; Belongs to the bacterial glucokinase family. (326 aa)
AOF95841.1Hypothetical protein. (136 aa)
AOF96826.1Eps_fam: capsular exopolysaccharide family domain protein; [M] COG3206 Uncharacterized protein involved in exopolysaccharide biosynthesis. (696 aa)
AOF96722.1GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (553 aa)
AOF97952.1Conserved hypothetical protein; [S] COG5385 Uncharacterized protein conserved in bacteria. (215 aa)
AOF97651.1Response regulator; [T] COG0642 Signal transduction histidine kinase. (1119 aa)
AOF96008.1GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (660 aa)
AOF96825.1HWE histidine kinase family protein; [T] COG3920 Signal transduction histidine kinase. (530 aa)
prsKPEP_his_kin: putative PEP-CTERM system histidine kinase; [T] COG0642 Signal transduction histidine kinase. (688 aa)
BSY17_257GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (767 aa)
BSY17_263acCoA-C-Actrans: acetyl-CoA C-acyltransferase family protein; [I] COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (390 aa)
folKfolK: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase; [H] COG0801 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase. (165 aa)
AOF96672.1acCoA-C-Actrans: acetyl-CoA C-acyltransferase family protein; [I] COG0183 Acetyl-CoA acetyltransferase; Belongs to the thiolase-like superfamily. Thiolase family. (402 aa)
thiDHMP-P_kinase: hydroxymethylpyrimidine kinase/phosphomethylpyrimidine kinase; [H] COG0351 Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. (251 aa)
tpiATriose-phosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (250 aa)
AOF98268.1Sensory box protein; [T] COG0642 Signal transduction histidine kinase. (671 aa)
AOF96703.1PAS fold family protein; [T] COG3920 Signal transduction histidine kinase. (329 aa)
AOF97616.1Sensory box protein; [T] COG2202 FOG: PAS/PAC domain. (654 aa)
AOF96558.1pfkB carbohydrate kinase family protein; [G] COG0524 Sugar kinases, ribokinase family. (302 aa)
AOF97772.1Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein; [T] COG0642 Signal transduction histidine kinase. (441 aa)
ppdKPyru_phos_dikin: pyruvate, phosphate dikinase; [G] COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. (900 aa)
AOF98243.1Pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (431 aa)
lpdA-2lipoamide_DH: dihydrolipoyl dehydrogenase; [C] COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes. (471 aa)
AOF95756.1Sensory box protein; [T] COG2202 FOG: PAS/PAC domain. (782 aa)
AOF96688.1Aminoglycoside/hydroxyurea antibiotic resistance kinase family protein; [R] COG3178 Predicted phosphotransferase related to Ser/Thr protein kinases. (332 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (208 aa)
AOF97462.1HAMP domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. (756 aa)
AOF96100.1[T] COG3852 Signal transduction histidine kinase, nitrogen specific. (369 aa)
cmkCmk: cytidylate kinase; [F] COG0283 Cytidylate kinase. (211 aa)
BSY17_328Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein; [T] COG3920 Signal transduction histidine kinase. (339 aa)
tdk[F] COG1435 Thymidine kinase. (192 aa)
ribFribF: riboflavin biosynthesis protein RibF; [H] COG0196 FAD synthase; Belongs to the ribF family. (318 aa)
gpmA2,3-bisphosphoglycerate-dependent phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (228 aa)
BSY17_388Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein; [T] COG0642 Signal transduction histidine kinase. (460 aa)
BSY17_395Hypothetical protein; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (456 aa)
pdhAPyruvate dehydrogenase (acetyl-transferring) E1 component, alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (357 aa)
enoPhosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (424 aa)
anmKHypothetical protein; Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the anhydro-N-acetylmuramic acid kinase family. (361 aa)
BSY17_436Histidine kinase family protein; [T] COG3275 Putative regulator of cell autolysis. (370 aa)
BSY17_439RIO1 family protein. (291 aa)
BSY17_478[T] COG0642 Signal transduction histidine kinase. (1119 aa)
nadKATP-NAD kinase family protein; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (258 aa)
BSY17_556Thiolase, C-terminal domain protein; [I] COG0183 Acetyl-CoA acetyltransferase. (381 aa)
BSY17_558Hypothetical protein; Thiamine pyrophosphate enzyme, C-terminal TPP binding domain protein; [C] COG1071 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit. (320 aa)
BSY17_5602-oxoacid dehydrogenases acyltransferase family protein; [C] COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes. (489 aa)
cysCAdenylyl-sulfate kinase; Catalyzes the synthesis of activated sulfate. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. CysN/NodQ subfamily. (641 aa)
pykPyruv_kin: pyruvate kinase; [G] COG0469 Pyruvate kinase; Belongs to the pyruvate kinase family. (483 aa)
ptsPPTS_I_fam: phosphoenolpyruvate-protein phosphotransferase; [T] COG3605 Signal transduction protein containing GAF and PtsI domains; Belongs to the PEP-utilizing enzyme family. (757 aa)
BSY17_742Asp_kinase: aspartate kinase domain protein; [E] COG0527 Aspartokinases; Belongs to the aspartokinase family. (421 aa)
BSY17_756HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (517 aa)
BSY17_757Hypothetical protein; HPr Serine kinase C-terminal domain protein; [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism. (144 aa)
BSY17_759[G] COG2893 Phosphotransferase system, mannose/fructose-specific component IIA. (134 aa)
BSY17_865HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (447 aa)
BSY17_892GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (569 aa)
BSY17_911HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (448 aa)
Your Current Organism:
Sphingobium sp. RAC03
NCBI taxonomy Id: 1843368
Other names: S. sp. RAC03
Server load: low (12%) [HD]