(81 nodes) Protein modification process network (Sphingobium sp. RAC03)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AOF96288.1	[T] COG0642 Signal transduction histidine kinase. (663 aa)
	AOF95998.1	Putative membrane protein. (632 aa)
	AOF96134.1	[O] COG3823 Glutamine cyclotransferase. (255 aa)
	AOF96674.1	Sensory box protein; [T] COG0642 Signal transduction histidine kinase. (807 aa)
	AOF96916.1	Winged helix-turn-helix DNA-binding family protein; [S] COG3177 Uncharacterized conserved protein. (377 aa)
	AOF97920.1	[O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family. (225 aa)
	BSY17_122	[T] COG0642 Signal transduction histidine kinase. (571 aa)
	AOF96995.1	Hypothetical protein. (77 aa)
	AOF96695.1	[NT] COG2201 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain. (140 aa)
	AOF97400.1	Cupin superfamily protein; [S] COG2850 Uncharacterized conserved protein. (383 aa)
	prmC	protein-(glutamine-N5) methyltransferase, release factor-specific; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (271 aa)
	AOF98213.1	Kinase/pyrophosphorylase family protein; Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. (275 aa)
	BSY17_145	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein; [T] COG0642 Signal transduction histidine kinase. (457 aa)
	AOF97621.1	Low molecular weight phosphotyrosine phosphatase family protein; [T] COG0394 Protein-tyrosine-phosphatase; Belongs to the low molecular weight phosphotyrosine protein phosphatase family. (183 aa)
	AOF98378.1	Dolichyl-phosphate-mannose-mannosyltransferase family protein. (503 aa)
	AOF95556.1	FIST N domain protein; [S] COG3287 Uncharacterized conserved protein. (386 aa)
	AOF98470.1	Sensory box protein; [T] COG0642 Signal transduction histidine kinase. (749 aa)
	acpS	Holo-[acyl-carrier-protein] synthase; Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein; Belongs to the P-Pant transferase superfamily. AcpS family. (133 aa)
	BSY17_981	HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (467 aa)
	BSY17_915	[O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family. (309 aa)
	BSY17_911	HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (448 aa)
	BSY17_892	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (569 aa)
	BSY17_865	HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (447 aa)
	lipB	Lipoyl(octanoyl) transferase; Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate- dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate. (231 aa)
	BSY17_761	[O] COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family. (196 aa)
	BSY17_757	Hypothetical protein; HPr Serine kinase C-terminal domain protein; [T] COG1493 Serine kinase of the HPr protein, regulates carbohydrate metabolism. (144 aa)
	BSY17_756	HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (517 aa)
	BSY17_71	Hypothetical protein; [S] COG2135 Uncharacterized conserved protein. (63 aa)
	BSY17_703	[J] COG2264 Ribosomal protein L11 methylase. (332 aa)
	BSY17_683	Sugar-transfer associated ATP-grasp family protein. (362 aa)
	BSY17_640	apbE family protein; Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. Belongs to the ApbE family. (289 aa)
	map-2	Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (275 aa)
	BSY17_598	[O] COG3555 Aspartyl/asparaginyl beta-hydroxylase and related dioxygenases. (379 aa)
	BSY17_591	Hypothetical protein. (465 aa)
	map	Methionine aminopeptidase, type I; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (259 aa)
	BSY17_509	portal_HK97: phage portal protein, HK97 family; [S] COG4695 Phage-related protein. (381 aa)
	BSY17_478	[T] COG0642 Signal transduction histidine kinase. (1119 aa)
	BSY17_47	Hypothetical protein. (220 aa)
	BSY17_46	Hypothetical protein; Belongs to the SOS response-associated peptidase family. (216 aa)
	BSY17_436	Histidine kinase family protein; [T] COG3275 Putative regulator of cell autolysis. (370 aa)
	BSY17_388	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein; [T] COG0642 Signal transduction histidine kinase. (460 aa)
	AOF96088.1	2OG-Fe(II) oxygenase superfamily protein. (215 aa)
	rimO	Ribosomal protein S12 methylthiotransferase RimO; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (460 aa)
	lipA	Lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (313 aa)
	AOF96100.1	[T] COG3852 Signal transduction histidine kinase, nitrogen specific. (369 aa)
	AOF97462.1	HAMP domain protein; [T] COG5000 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation. (756 aa)
	AOF95756.1	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain. (782 aa)
	rimI	rimI: ribosomal-protein-alanine acetyltransferase; [R] COG0456 Acetyltransferases. (159 aa)
	ccmE	ccmE family protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (148 aa)
	AOF97772.1	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase family protein; [T] COG0642 Signal transduction histidine kinase. (441 aa)
	AOF97616.1	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain. (654 aa)
	AOF96703.1	PAS fold family protein; [T] COG3920 Signal transduction histidine kinase. (329 aa)
	AOF98268.1	Sensory box protein; [T] COG0642 Signal transduction histidine kinase. (671 aa)
	bpt	Hypothetical protein; Functions in the N-end rule pathway of protein degradation where it conjugates Leu from its aminoacyl-tRNA to the N-termini of proteins containing an N-terminal aspartate or glutamate. Belongs to the R-transferase family. Bpt subfamily. (272 aa)
	AOF95987.1	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD family protein; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (246 aa)
	AOF96938.1	Hypothetical protein; Belongs to the SOS response-associated peptidase family. (216 aa)
	BSY17_257	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (767 aa)
	prsK	PEP_his_kin: putative PEP-CTERM system histidine kinase; [T] COG0642 Signal transduction histidine kinase. (688 aa)
	AOF96008.1	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (660 aa)
	AOF97651.1	Response regulator; [T] COG0642 Signal transduction histidine kinase. (1119 aa)
	AOF97952.1	Conserved hypothetical protein; [S] COG5385 Uncharacterized protein conserved in bacteria. (215 aa)
	cobB	Sir2 family protein; [K] COG0846 NAD-dependent protein deacetylases, SIR2 family; Belongs to the sirtuin family. Class III subfamily. (233 aa)
	AOF96722.1	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (553 aa)
	AOF96826.1	Eps_fam: capsular exopolysaccharide family domain protein; [M] COG3206 Uncharacterized protein involved in exopolysaccharide biosynthesis. (696 aa)
	AOF95841.1	Hypothetical protein. (136 aa)
	AOF96376.1	fkbM_fam: methyltransferase, FkbM family domain protein; [QR] COG0500 SAM-dependent methyltransferases. (242 aa)
	AOF98279.1	HAMP domain protein; [T] COG0642 Signal transduction histidine kinase. (438 aa)
	AOF96621.1	Histidine kinase family protein; [T] COG2972 Predicted signal transduction protein with a C-terminal ATPase domain. (368 aa)
	AOF96482.1	cheR methyltransferase, SAM binding domain protein; [NT] COG1352 Methylase of chemotaxis methyl-accepting proteins. (291 aa)
	AOF97423.1	cheB methylesterase family protein; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family. (360 aa)
	AOF97240.1	cheW-like domain protein; [NT] COG0643 Chemotaxis protein histidine kinase and related kinases. (793 aa)
	AOF97194.1	lemA family protein; [S] COG1704 Uncharacterized conserved protein. (200 aa)
	AOF96585.1	Putative hpr(Ser) kinase/phosphatase. (287 aa)
	AOF97948.1	Sensory box protein; [T] COG0642 Signal transduction histidine kinase. (428 aa)
	AOF96208.1	-L-isoaspartate family protein; [O] COG2518 Protein-L-isoaspartate carboxylmethyltransferase. (208 aa)
	AOF96870.1	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain. (508 aa)
	AOF95819.1	Hypothetical protein. (164 aa)
	AOF95596.1	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain. (935 aa)
	AOF96306.1	Cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD family protein; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (150 aa)
	AOF97960.1	Putative membrane protein. (590 aa)
	hemC	Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (285 aa)

Your Current Organism:

Sphingobium sp. RAC03

NCBI taxonomy Id: 1843368
Other names: S. sp. RAC03

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AOF95556.1	AOF96288.1	BSY17_1613	BSY17_2312	FIST N domain protein; [S] COG3287 Uncharacterized conserved protein.	[T] COG0642 Signal transduction histidine kinase.	0.703
AOF95556.1	AOF98470.1	BSY17_1613	BSY17_1614	FIST N domain protein; [S] COG3287 Uncharacterized conserved protein.	Sensory box protein; [T] COG0642 Signal transduction histidine kinase.	0.959
AOF95596.1	AOF96008.1	BSY17_1736	BSY17_2557	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	0.406
AOF95596.1	AOF96288.1	BSY17_1736	BSY17_2312	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	[T] COG0642 Signal transduction histidine kinase.	0.880
AOF95596.1	AOF96674.1	BSY17_1736	BSY17_1120	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	Sensory box protein; [T] COG0642 Signal transduction histidine kinase.	0.620
AOF95596.1	AOF96722.1	BSY17_1736	BSY17_2511	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	0.777
AOF95596.1	AOF96870.1	BSY17_1736	BSY17_1911	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain.	0.732
AOF95596.1	AOF97240.1	BSY17_1736	BSY17_2132	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	cheW-like domain protein; [NT] COG0643 Chemotaxis protein histidine kinase and related kinases.	0.661
AOF95596.1	AOF97616.1	BSY17_1736	BSY17_2859	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain.	0.863
AOF95596.1	AOF97651.1	BSY17_1736	BSY17_2555	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	Response regulator; [T] COG0642 Signal transduction histidine kinase.	0.750
AOF95596.1	AOF98268.1	BSY17_1736	BSY17_2815	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	Sensory box protein; [T] COG0642 Signal transduction histidine kinase.	0.705
AOF95596.1	AOF98470.1	BSY17_1736	BSY17_1614	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	Sensory box protein; [T] COG0642 Signal transduction histidine kinase.	0.863
AOF95596.1	BSY17_257	BSY17_1736	BSY17_257	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	0.717
AOF95596.1	BSY17_478	BSY17_1736	BSY17_478	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	[T] COG0642 Signal transduction histidine kinase.	0.543
AOF95596.1	BSY17_756	BSY17_1736	BSY17_756	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	HAMP domain protein; [T] COG0642 Signal transduction histidine kinase.	0.526
AOF95596.1	BSY17_892	BSY17_1736	BSY17_892	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	GGDEF: diguanylate cyclase domain protein; [T] COG5001 Predicted signal transduction protein containing a membrane domain, an EAL and a GGDEF domain.	0.501
AOF95756.1	AOF96100.1	BSY17_2974	BSY17_3009	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain.	[T] COG3852 Signal transduction histidine kinase, nitrogen specific.	0.432
AOF95756.1	AOF96288.1	BSY17_2974	BSY17_2312	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain.	[T] COG0642 Signal transduction histidine kinase.	0.929
AOF95756.1	AOF96674.1	BSY17_2974	BSY17_1120	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain.	Sensory box protein; [T] COG0642 Signal transduction histidine kinase.	0.780
AOF95756.1	AOF97616.1	BSY17_2974	BSY17_2859	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain.	Sensory box protein; [T] COG2202 FOG: PAS/PAC domain.	0.484