(13 nodes) RNA Polymerase II Transcription Elongation, and Activator network (Giardia lamblia ATCC 50803)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	GL50803_20633	Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (130 aa)
	GL50803_14413	DNA-directed RNA polymerase RPB10. (122 aa)
	GL50803_15000	TFIIH P44. (406 aa)
	GL50803_5158	Transcription factor TFIIS. (346 aa)
	GL50803_11290	Kinase, CMGC CDK. (554 aa)
	GL50803_16512	DNA repair helicase TFIIH P90. (765 aa)
	GL50803_4328	TFIIH basal transcription factor complex helicase subunit. (840 aa)
	GL50803_15955	DNA-directed RNA polymerase II RPB6. (104 aa)
	GL50803_89347	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (2076 aa)
	GL50803_3036	RNA polymerase II subunit Rpb11. (131 aa)
	GL50803_7474	DNA-directed RNA polymerase RPB3. (326 aa)
	GL50803_17448	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1293 aa)
	GL50803_15144	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. (150 aa)

Your Current Organism:

Giardia lamblia ATCC 50803

NCBI taxonomy Id: 184922
Other names: G. lamblia ATCC 50803, Giardia intestinalis ATCC 50803

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GL50803_11290	GL50803_14413	A8BMI3	A8BAL6	Kinase, CMGC CDK.	DNA-directed RNA polymerase RPB10.	0.824
GL50803_11290	GL50803_15000	A8BMI3	A8BAS0	Kinase, CMGC CDK.	TFIIH P44.	0.990
GL50803_11290	GL50803_15144	A8BMI3	E2RU32	Kinase, CMGC CDK.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.834
GL50803_11290	GL50803_15955	A8BMI3	E2RTN0	Kinase, CMGC CDK.	DNA-directed RNA polymerase II RPB6.	0.848
GL50803_11290	GL50803_16512	A8BMI3	A8BMI7	Kinase, CMGC CDK.	DNA repair helicase TFIIH P90.	0.986
GL50803_11290	GL50803_17448	A8BMI3	E2RU19	Kinase, CMGC CDK.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.899
GL50803_11290	GL50803_20633	A8BMI3	A8B8I7	Kinase, CMGC CDK.	Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.774
GL50803_11290	GL50803_3036	A8BMI3	E2RTX5	Kinase, CMGC CDK.	RNA polymerase II subunit Rpb11.	0.844
GL50803_11290	GL50803_4328	A8BMI3	A8BYS3	Kinase, CMGC CDK.	TFIIH basal transcription factor complex helicase subunit.	0.999
GL50803_11290	GL50803_5158	A8BMI3	A8BI36	Kinase, CMGC CDK.	Transcription factor TFIIS.	0.712
GL50803_11290	GL50803_7474	A8BMI3	E2RTY7	Kinase, CMGC CDK.	DNA-directed RNA polymerase RPB3.	0.941
GL50803_11290	GL50803_89347	A8BMI3	E2RTQ5	Kinase, CMGC CDK.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.901
GL50803_14413	GL50803_11290	A8BAL6	A8BMI3	DNA-directed RNA polymerase RPB10.	Kinase, CMGC CDK.	0.824
GL50803_14413	GL50803_15000	A8BAL6	A8BAS0	DNA-directed RNA polymerase RPB10.	TFIIH P44.	0.976
GL50803_14413	GL50803_15144	A8BAL6	E2RU32	DNA-directed RNA polymerase RPB10.	DNA-directed RNA polymerases I, II, and III subunit RPABC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non- coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively.	0.999
GL50803_14413	GL50803_15955	A8BAL6	E2RTN0	DNA-directed RNA polymerase RPB10.	DNA-directed RNA polymerase II RPB6.	0.999
GL50803_14413	GL50803_16512	A8BAL6	A8BMI7	DNA-directed RNA polymerase RPB10.	DNA repair helicase TFIIH P90.	0.976
GL50803_14413	GL50803_17448	A8BAL6	E2RU19	DNA-directed RNA polymerase RPB10.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.999
GL50803_14413	GL50803_20633	A8BAL6	A8B8I7	DNA-directed RNA polymerase RPB10.	Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.999
GL50803_14413	GL50803_3036	A8BAL6	E2RTX5	DNA-directed RNA polymerase RPB10.	RNA polymerase II subunit Rpb11.	0.999