STRINGSTRING
GL50803_137745 GL50803_137745 GL50803_4369 GL50803_4369 GL50803_24636 GL50803_24636 GL50803_5631 GL50803_5631 GL50803_14195 GL50803_14195 GL50803_9487 GL50803_9487 GL50803_17073 GL50803_17073 GL50803_7615 GL50803_7615 GL50803_17291 GL50803_17291 GL50803_6918 GL50803_6918 GL50803_6980 GL50803_6980 MCM7 MCM7 GL50803_8423 GL50803_8423 FEN1 FEN1 BIVM BIVM GL50803_34058 GL50803_34058 GL50803_137731 GL50803_137731 GL50803_23185 GL50803_23185 GL50803_17465 GL50803_17465 GL50803_15239 GL50803_15239 GL50803_16127 GL50803_16127 GL50803_9287 GL50803_9287 GL50803_16747 GL50803_16747 GL50803_7207 GL50803_7207 GL50803_33433 GL50803_33433 GL50803_35094 GL50803_35094 GL50803_17438 GL50803_17438 GL50803_16805 GL50803_16805 GL50803_23064 GL50803_23064 GL50803_16810 GL50803_16810 GL50803_13075 GL50803_13075 GL50803_9184 GL50803_9184 GL50803_9834 GL50803_9834 GL50803_6564 GL50803_6564 GL50803_17103 GL50803_17103 MCM7-3 MCM7-3 GL50803_10775 GL50803_10775 GL50803_17390 GL50803_17390 GL50803_15392 GL50803_15392 GL50803_89112 GL50803_89112 GL50803_16214 GL50803_16214 GL50803_112076 GL50803_112076 NTH1 NTH1 GL50803_16188 GL50803_16188 GL50803_9922 GL50803_9922 GL50803_14493 GL50803_14493 GL50803_14095 GL50803_14095 GL50803_7890 GL50803_7890 GL50803_27326 GL50803_27326 GL50803_16149 GL50803_16149 GL50803_7648 GL50803_7648 GL50803_7649 GL50803_7649 GL50803_114670 GL50803_114670 GL50803_22138 GL50803_22138 GL50803_14208 GL50803_14208 GL50803_32879 GL50803_32879 GL50803_5925 GL50803_5925 GL50803_115464 GL50803_115464 GL50803_15145 GL50803_15145 GL50803_113252 GL50803_113252 GL50803_13346 GL50803_13346 GL50803_17495 GL50803_17495 GL50803_13104 GL50803_13104 GL50803_27735 GL50803_27735 GL50803_103935 GL50803_103935 GL50803_33083 GL50803_33083
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GL50803_137745Structural maintenance of chromosomes protein. (1231 aa)
GL50803_4369Dual specificity phosphatase Cdc25, putative. (120 aa)
GL50803_24636Replication factor C, subunit 3. (321 aa)
GL50803_5631TFIIH basal transcription factor complex helicase subunit. (1059 aa)
GL50803_14195Pms1-like protein. (727 aa)
GL50803_9487Kinase. (925 aa)
GL50803_17073Kinase. (799 aa)
GL50803_7615DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (896 aa)
GL50803_17291Orc4. (463 aa)
GL50803_6918DNA damage repair protein. (867 aa)
GL50803_6980DNA pol/primase, large sub. (539 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (1075 aa)
GL50803_8423Enkurin domain-containing protein. (293 aa)
FEN1Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (361 aa)
BIVMBasic immunoglobulin-like variable motif-containing protein; Belongs to the BIVM family. (271 aa)
GL50803_34058DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1106 aa)
GL50803_137731Uncharacterized protein. (1043 aa)
GL50803_23185Uncharacterized protein. (1576 aa)
GL50803_17465Structural maintenance of chromosomes protein. (1435 aa)
GL50803_15239Uncharacterized protein. (490 aa)
GL50803_16127Replication factor C, subunit 5. (373 aa)
GL50803_9287Replication factor C, sub 2. (351 aa)
GL50803_16747ATP-dependent DNA helicase; Belongs to the helicase family. (772 aa)
GL50803_7207Uncharacterized protein. (1058 aa)
GL50803_33433Uncharacterized protein. (233 aa)
GL50803_35094DNA polymerase. (1329 aa)
GL50803_17438ATP-dependent DNA helicase recQ. (850 aa)
GL50803_16805Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2633 aa)
GL50803_23064DNA polymerase epsilon, catalytic subunit. (2590 aa)
GL50803_16810DINP protein, human muc B family. (675 aa)
GL50803_13075Uncharacterized protein. (483 aa)
GL50803_9184Transducin. (776 aa)
GL50803_9834DNA-(apurinic or apyrimidinic site) lyase; Belongs to the DNA repair enzymes AP/ExoA family. (322 aa)
GL50803_6564Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (299 aa)
GL50803_17103Orc1/CDC6. (372 aa)
MCM7-3DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (704 aa)
GL50803_10775Uncharacterized protein. (450 aa)
GL50803_17390DNA helicase; Belongs to the MCM family. (954 aa)
GL50803_15392Replication factor C, subunit 1. (890 aa)
GL50803_89112DNA helicase; Belongs to the MCM family. (730 aa)
GL50803_16214MCM3; Belongs to the MCM family. (927 aa)
GL50803_112076Kinase, CDC7. (1697 aa)
NTH1Endonuclease III homolog; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. (323 aa)
GL50803_16188SMC1 beta-like protein. (1353 aa)
GL50803_9922Exonuclease 1. (705 aa)
GL50803_14493Mre11, putative. (274 aa)
GL50803_14095Replication factor C, subunit 4. (322 aa)
GL50803_7890Transcriptional regulator ATRX, putative. (1367 aa)
GL50803_27326DNA polymerase. (1730 aa)
GL50803_16149Mlh1-like protein. (786 aa)
GL50803_7648SMC6 protein. (1305 aa)
GL50803_7649DNA ligase. (810 aa)
GL50803_114670DNA primase; Belongs to the eukaryotic-type primase small subunit family. (449 aa)
GL50803_22138ATPase, AAA family. (509 aa)
GL50803_14208XPGN domain-containing protein. (832 aa)
GL50803_32879SMC_N domain-containing protein. (1387 aa)
GL50803_5925ERCC4 domain-containing protein. (881 aa)
GL50803_115464Uncharacterized protein. (472 aa)
GL50803_15145AAA domain-containing protein. (664 aa)
GL50803_113252Msh2-like protein. (963 aa)
GL50803_13346Dmc1b; Belongs to the RecA family. (368 aa)
GL50803_17495RAD50 DNA repair protein, putative. (1387 aa)
GL50803_13104DNA repair protein RAD51; Belongs to the RecA family. (389 aa)
GL50803_27735Mre11. (817 aa)
GL50803_103935DNA repair protein RAD52. (341 aa)
GL50803_33083Mlh2-like protein. (1474 aa)
Your Current Organism:
Giardia lamblia ATCC 50803
NCBI taxonomy Id: 184922
Other names: G. lamblia ATCC 50803, Giardia intestinalis ATCC 50803
Server load: low (18%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.