(27 nodes) Mitotic cell cycle, and Spindle midzone network (Giardia lamblia ATCC 50803)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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protein homology

Your Input:
	GL50803_102890	BUB3. (363 aa)
	GL50803_16802	Kinase, CMGC CDK; Belongs to the protein kinase superfamily. (291 aa)
	GL50803_17139	Kinase, CMGC CMGC-GL1. (613 aa)
	GL50803_16224	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (905 aa)
	GL50803_17505	Cyclin B-like protein; Belongs to the cyclin family. (557 aa)
	MCM7-2	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (824 aa)
	GL50803_10908	WD-40 repeat protein family. (711 aa)
	GL50803_15397	Kinase, CMGC CDK; Belongs to the protein kinase superfamily. (340 aa)
	GL50803_3977	G2/mitotic-specific cyclin B; Belongs to the cyclin family. (341 aa)
	GL50803_4405	Kinase, TTK. (684 aa)
	GL50803_2661	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (85 aa)
	GL50803_90767	Separase. (1642 aa)
	GL50803_9422	Kinase, CMGC CDK; Belongs to the protein kinase superfamily. (351 aa)
	GL50803_12095	Kinase, NEK-frag. (576 aa)
	GL50803_16425	Kinesin-5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1066 aa)
	GL50803_8827	Protein required for cell viability, possible role in assembly of the ribosome. (505 aa)
	GL50803_90575	Kinase. (847 aa)
	GL50803_15962	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (923 aa)
	GL50803_91480	STU2-like protein. (1712 aa)
	GL50803_104150	Serine/threonine-protein kinase PLK. (678 aa)
	GL50803_100955	Mitotic spindle checkpoint protein MAD2. (203 aa)
	GL50803_14488	Cyclin A; Belongs to the cyclin family. (354 aa)
	GL50803_96399	Spindle pole body protein, putative. (1670 aa)
	GL50803_8037	Kinase, CMGC CDK; Belongs to the protein kinase superfamily. (308 aa)
	GL50803_16945	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (714 aa)
	GL50803_5358	Aurora kinase; Belongs to the protein kinase superfamily. (311 aa)
	GL50803_14048	EB1. (238 aa)

Your Current Organism:

Giardia lamblia ATCC 50803

NCBI taxonomy Id: 184922
Other names: G. lamblia ATCC 50803, Giardia intestinalis ATCC 50803

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GL50803_100955	GL50803_102890	A8BQB1	A8B1Y9	Mitotic spindle checkpoint protein MAD2.	BUB3.	0.999
GL50803_100955	GL50803_104150	A8BQB1	A8BPK8	Mitotic spindle checkpoint protein MAD2.	Serine/threonine-protein kinase PLK.	0.879
GL50803_100955	GL50803_10908	A8BQB1	A8B802	Mitotic spindle checkpoint protein MAD2.	WD-40 repeat protein family.	0.705
GL50803_100955	GL50803_12095	A8BQB1	A8BFQ4	Mitotic spindle checkpoint protein MAD2.	Kinase, NEK-frag.	0.591
GL50803_100955	GL50803_14048	A8BQB1	E2RU10	Mitotic spindle checkpoint protein MAD2.	EB1.	0.889
GL50803_100955	GL50803_14488	A8BQB1	A8BSI6	Mitotic spindle checkpoint protein MAD2.	Cyclin A; Belongs to the cyclin family.	0.784
GL50803_100955	GL50803_15397	A8BQB1	A8B8J3	Mitotic spindle checkpoint protein MAD2.	Kinase, CMGC CDK; Belongs to the protein kinase superfamily.	0.723
GL50803_100955	GL50803_15962	A8BQB1	A8BN58	Mitotic spindle checkpoint protein MAD2.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.614
GL50803_100955	GL50803_16224	A8BQB1	A8B4E4	Mitotic spindle checkpoint protein MAD2.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.756
GL50803_100955	GL50803_16425	A8BQB1	A8BH36	Mitotic spindle checkpoint protein MAD2.	Kinesin-5; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.756
GL50803_100955	GL50803_16802	A8BQB1	A8B2A9	Mitotic spindle checkpoint protein MAD2.	Kinase, CMGC CDK; Belongs to the protein kinase superfamily.	0.723
GL50803_100955	GL50803_16945	A8BQB1	E2RTQ2	Mitotic spindle checkpoint protein MAD2.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.694
GL50803_100955	GL50803_17139	A8BQB1	A8B4B8	Mitotic spindle checkpoint protein MAD2.	Kinase, CMGC CMGC-GL1.	0.723
GL50803_100955	GL50803_17505	A8BQB1	A8B6X7	Mitotic spindle checkpoint protein MAD2.	Cyclin B-like protein; Belongs to the cyclin family.	0.784
GL50803_100955	GL50803_2661	A8BQB1	A8BC79	Mitotic spindle checkpoint protein MAD2.	Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.	0.728
GL50803_100955	GL50803_3977	A8BQB1	A8B940	Mitotic spindle checkpoint protein MAD2.	G2/mitotic-specific cyclin B; Belongs to the cyclin family.	0.868
GL50803_100955	GL50803_4405	A8BQB1	A8BA50	Mitotic spindle checkpoint protein MAD2.	Kinase, TTK.	0.985
GL50803_100955	GL50803_5358	A8BQB1	E2RTQ7	Mitotic spindle checkpoint protein MAD2.	Aurora kinase; Belongs to the protein kinase superfamily.	0.909
GL50803_100955	GL50803_8037	A8BQB1	A8BZ95	Mitotic spindle checkpoint protein MAD2.	Kinase, CMGC CDK; Belongs to the protein kinase superfamily.	0.723
GL50803_100955	GL50803_8827	A8BQB1	A8BJ39	Mitotic spindle checkpoint protein MAD2.	Protein required for cell viability, possible role in assembly of the ribosome.	0.705