(18 nodes) Mixed, incl. Nucleotidyltransferase superfamily, and Gene silencing by RNA network (Giardia lamblia ATCC 50803)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

Your Input:
	GL50803_11540	Hexose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (512 aa)
	GL50803_6417	Gmyb11. (2085 aa)
	GL50803_10403	Uncharacterized protein. (131 aa)
	GL50803_16180	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated. (419 aa)
	GL50803_17166	Uncharacterized protein. (731 aa)
	Ago	Protein argonaute; Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity). Belongs to the argonaute family. Ago subfamily. (900 aa)
	GL50803_95880	Uncharacterized protein. (403 aa)
	GL50803_16568	Transcription factor, putative. (945 aa)
	GL50803_16285	Topoisomerase I-related protein. (520 aa)
	GL50803_97820	VSP, putative. (102 aa)
	GL50803_23756	Uncharacterized protein. (422 aa)
	GL50803_103887	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. (754 aa)
	GL50803_36493	VSP. (194 aa)
	GL50803_16863	Caffeine-induced death protein 1-like protein. (677 aa)
	GL50803_11912	Uncharacterized protein. (2013 aa)
	GL50803_87577	Uncharacterized protein. (302 aa)
	GL50803_102515	RNA-directed RNA polymerase, putative. (2001 aa)
	GL50803_137614	VSP AS12. (547 aa)

Your Current Organism:

Giardia lamblia ATCC 50803

NCBI taxonomy Id: 184922
Other names: G. lamblia ATCC 50803, Giardia intestinalis ATCC 50803

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Ago	GL50803_103887	A8BCK6	A8BQJ3	Protein argonaute; Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity). Belongs to the argonaute family. Ago subfamily.	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	0.608
Ago	GL50803_16568	A8BCK6	A8BJJ3	Protein argonaute; Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity). Belongs to the argonaute family. Ago subfamily.	Transcription factor, putative.	0.917
GL50803_102515	GL50803_103887	E2RTV4	A8BQJ3	RNA-directed RNA polymerase, putative.	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	0.964
GL50803_102515	GL50803_11912	E2RTV4	D3KG10	RNA-directed RNA polymerase, putative.	Uncharacterized protein.	0.640
GL50803_102515	GL50803_16180	E2RTV4	A8BA82	RNA-directed RNA polymerase, putative.	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	0.677
GL50803_103887	Ago	A8BQJ3	A8BCK6	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Protein argonaute; Plays an essential role in growth and, with Dicer, also involved in microRNA (miRNA)-mediated translational repression. The RNA interference pathway is implicated in antigenic variation having a role in regulation of variant-specific surface protein (VSP)-coding gene expression. Several VSP genes are transcribed but only transcripts encoding the VSP to be expressed accumulate. Antisense RNAs corresponding to the silenced VSP genes are detected (By similarity). Belongs to the argonaute family. Ago subfamily.	0.608
GL50803_103887	GL50803_102515	A8BQJ3	E2RTV4	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	RNA-directed RNA polymerase, putative.	0.964
GL50803_103887	GL50803_11540	A8BQJ3	A8B299	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Hexose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	0.429
GL50803_103887	GL50803_137614	A8BQJ3	E2RU01	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	VSP AS12.	0.822
GL50803_103887	GL50803_16180	A8BQJ3	A8BA82	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Protein phosphatase methylesterase 1; Demethylates proteins that have been reversibly carboxymethylated.	0.838
GL50803_103887	GL50803_16568	A8BQJ3	A8BJJ3	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Transcription factor, putative.	0.592
GL50803_103887	GL50803_16863	A8BQJ3	A8BVU1	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	Caffeine-induced death protein 1-like protein.	0.640
GL50803_103887	GL50803_36493	A8BQJ3	A8BVQ2	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	VSP.	0.826
GL50803_103887	GL50803_97820	A8BQJ3	A8BPN5	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	VSP, putative.	0.822
GL50803_10403	GL50803_16568	A8B873	A8BJJ3	Uncharacterized protein.	Transcription factor, putative.	0.826
GL50803_10403	GL50803_23756	A8B873	A8BQ51	Uncharacterized protein.	Uncharacterized protein.	0.826
GL50803_10403	GL50803_87577	A8B873	D3KI75	Uncharacterized protein.	Uncharacterized protein.	0.826
GL50803_11540	GL50803_103887	A8B299	A8BQJ3	Hexose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	0.429
GL50803_11540	GL50803_6417	A8B299	A8B4I7	Hexose transporter; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.	Gmyb11.	0.826
GL50803_11912	GL50803_102515	D3KG10	E2RTV4	Uncharacterized protein.	RNA-directed RNA polymerase, putative.	0.640