(134 nodes) Ribonucleoprotein complex biogenesis network (Giardia lamblia ATCC 50803)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GL50803_17335	Kinase, CMGC SRPK. (902 aa)
	GL50803_32297	Small nuclear ribonucleoprotein Sm D2, putative. (124 aa)
	GL50803_15538	Eukaryotic translation initiation factor 5. (337 aa)
	GL50803_14174	Glutamate-rich WD-repeat protein. (531 aa)
	GL50803_17387	ATP-dependent RNA helicase DHR1, putative. (1478 aa)
	GL50803_17244	Ribosomal protein L7a. (225 aa)
	GL50803_5947	Ribosomal protein L35a. (123 aa)
	GL50803_4652	Ribosomal protein S16; Belongs to the universal ribosomal protein uS9 family. (158 aa)
	GL50803_10193	WD-repeat membrane protein, putative. (960 aa)
	GL50803_10577	Nucleolar protein NOP5. (498 aa)
	GL50803_10569	Kri1_C domain-containing protein. (505 aa)
	GL50803_8892	Uncharacterized protein. (468 aa)
	GL50803_3589	Ribosome biogenesis protein Brix. (348 aa)
	GL50803_10755	Splicing factor 3A subunit 2. (222 aa)
	GL50803_2825	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (122 aa)
	GL50803_17112	U3 small nucleolar ribonucleoprotein protein IMP4, putative. (366 aa)
	GL50803_8827	Protein required for cell viability, possible role in assembly of the ribosome. (505 aa)
	GL50803_137690	Helicase C-terminal domain-containing protein. (263 aa)
	GL50803_33022	Uncharacterized protein. (262 aa)
	GL50803_95898	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (560 aa)
	GL50803_4257	CBF domain-containing protein. (792 aa)
	GL50803_8794	H/ACA ribonucleoprotein complex subunit; Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs. (183 aa)
	GL50803_2400	Ribonuclease P protein subunit p29; Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. (198 aa)
	GL50803_9825	RuvB-like helicase; Belongs to the RuvB family. (468 aa)
	GL50803_15046	Ribosomal protein L26. (135 aa)
	GL50803_12055	Elongation factor 2. (1198 aa)
	GL50803_13220	ATP-dependent RNA helicase. (756 aa)
	GL50803_14098	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (771 aa)
	GL50803_6211	Protein required for cell viability. (746 aa)
	GL50803_4954	Small nuclear ribonucleoprotein F, putative. (107 aa)
	GL50803_7766	40S ribosomal protein SA; Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. (245 aa)
	GL50803_16718	Partner of Nob1. (201 aa)
	GL50803_15026	Src-associated protein-like protein. (593 aa)
	GL50803_13897	MCT-1 protein-like protein. (237 aa)
	GL50803_13616	Glycine-rich protein. (484 aa)
	GL50803_16042	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (632 aa)
	GL50803_42442	Transitional endoplasmic reticulum ATPase. (808 aa)
	GL50803_1894	U3 small nucleolar RNA-associated protein 11, putative. (227 aa)
	GL50803_6835	Brix domain containing protein. (332 aa)
	GL50803_13791	ATP-dependent RNA helicase. (625 aa)
	GL50803_16173	U3 small nucleolar ribonucleoprotein protein IMP4, putative. (283 aa)
	GL50803_13926	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (171 aa)
	GL50803_15260	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. (145 aa)
	GL50803_16993	FtsJ cell division protein, putative. (1084 aa)
	GL50803_5359	Nucleolar protein NOP5. (613 aa)
	GL50803_16882	Bystin. (479 aa)
	GL50803_10810	Uncharacterized protein. (279 aa)
	GL50803_2750	Uncharacterized protein. (182 aa)
	GL50803_9274	U3 small nucleolar ribonucleoprotein protein MPP10, putative. (374 aa)
	GL50803_34141	Nin one binding protein-like protein; Belongs to the NOB1 family. (461 aa)
	GL50803_17449	RIO1-like protein. (434 aa)
	GL50803_97219	Fibrillarin-like pre-rRNA processing protein Narcisi et al. (327 aa)
	GL50803_15581	WD_REPEATS_REGION domain-containing protein. (342 aa)
	EIF6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. (246 aa)
	GL50803_11755	Uncharacterized protein. (260 aa)
	GL50803_15495	RRM domain-containing protein. (871 aa)
	GL50803_11319	U3 small nucleolar ribonucleoprotein protein IMP3, putative. (184 aa)
	GL50803_9119	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (450 aa)
	GL50803_14869	Ribosomal protein L24. (189 aa)
	GL50803_17541	WD-repeat domain 17 isoform 1. (1616 aa)
	GL50803_103285	Protein BAP28. (2381 aa)
	GL50803_10459	CGI-35 protein, putative. (190 aa)
	GL50803_22802	Shwachman-Bodian-Diamond syndrome protein-like protein. (251 aa)
	GL50803_8243	Uncharacterized protein. (674 aa)
	GL50803_8782	Protein required for cell viability. (569 aa)
	GL50803_89887	Nucleolar GTP-binding protein 2; GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation. Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily. (737 aa)
	GL50803_5786	Ribosome biogenesis protein NEP1, putative. (231 aa)
	GL50803_15513	WD-repeat protein BING4. (562 aa)
	GL50803_102722	Ribosome biogenesis protein BMS1. (1293 aa)
	GL50803_6054	RNA binding putative. (188 aa)
	GL50803_17146	Helicase. (1361 aa)
	GL50803_5632	Exosome complex exonuclease, putative. (314 aa)
	GL50803_10297	U3 small nucleolar RNA interacting protein, putative. (449 aa)
	GL50803_14091	Ribosomal protein L14. (131 aa)
	GL50803_14089	WD_REPEATS_REGION domain-containing protein. (506 aa)
	GL50803_24860	60S ribosomal export protein NMD3; Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit; Belongs to the NMD3 family. (491 aa)
	GL50803_113971	Transducin. (481 aa)
	GL50803_15531	Periodic tryptophan protein 1, putative. (504 aa)
	GL50803_17395	Ribosomal protein L5. (297 aa)
	GL50803_8035	Ribosome biogenesis protein BOP1 homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the WD repeat BOP1/ERB1 family. (755 aa)
	GL50803_14451	ATP-dependent RNA helicase. (554 aa)
	GL50803_7662	RNase L inhibitor. (674 aa)
	GL50803_3294	Uncharacterized protein. (197 aa)
	GL50803_5522	Uncharacterized protein. (1007 aa)
	GL50803_17245	Uncharacterized protein. (72 aa)
	GL50803_7517	CLP1_P domain-containing protein. (607 aa)
	GL50803_11190	Uncharacterized protein. (538 aa)
	GL50803_137724	Uncharacterized protein. (380 aa)
	GL50803_12981	Ribosomal protein S5. (190 aa)
	GL50803_16313	Pescadillo homolog; Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit; Belongs to the pescadillo family. (581 aa)
	GL50803_11984	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family. (176 aa)
	GL50803_91398	Eukaryotic translation initiation factor 2 beta subunit. (330 aa)
	GL50803_14842	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (316 aa)
	GL50803_14277	N-acetyltransferase-like protein. (1025 aa)
	GL50803_5661	Protein MAK16 homolog; Belongs to the MAK16 family. (236 aa)
	GL50803_15555	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. (730 aa)
	GL50803_1830	Ribosomal large subunit pseudouridine synthase D. (250 aa)
	GL50803_17565	RuvB-like helicase; Belongs to the RuvB family. (483 aa)
	GL50803_40521	SBDS domain-containing protein. (292 aa)
	GL50803_112114	Splicing factor-like protein, putative. (2309 aa)
	GL50803_19867	Uncharacterized protein. (129 aa)
	GL50803_113655	Uncharacterized protein. (561 aa)
	GL50803_14329	40S ribosomal protein S7; Belongs to the eukaryotic ribosomal protein eS7 family. (190 aa)
	GL50803_14327	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (304 aa)
	GL50803_9352	U5 small nuclear ribonucleoprotein 200 kDa helicase, putative. (1594 aa)
	GL50803_21512	S-adenosylmethionine-dependent methyltransferase, putative. (291 aa)
	GL50803_14702	rRNA biogenesis protein RRP5. (1842 aa)
	GL50803_16264	WD-40 repeat protein. (1041 aa)
	GL50803_19436	Ribosomal protein L7. (235 aa)
	GL50803_8361	SOF1 protein. (516 aa)
	GL50803_6177	Ribosome subunit biogenesis protein NIP7. (231 aa)
	GL50803_13661	Eukaryotic translation initiation factor 3 subunit 2. (350 aa)
	GL50803_14119	Zinc finger domain protein. (268 aa)
	GL50803_6133	Ribosomal protein L35. (152 aa)
	GL50803_5294	Protein F10G7.1. (826 aa)
	GL50803_90950	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (900 aa)
	GL50803_16463	Probable ribosome biogenesis protein GL50803_16463; Probable pre-rRNA processing protein involved in ribosome biogenesis. (320 aa)
	GL50803_103887	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs. (754 aa)
	GL50803_5811	Serine/threonine protein kinase. (416 aa)
	GL50803_16658	Uncharacterized protein. (542 aa)
	GL50803_23767	Uncharacterized protein. (494 aa)
	GL50803_16299	Protein SDA1; Required for 60S pre-ribosomal subunits export to the cytoplasm; Belongs to the SDA1 family. (863 aa)
	GL50803_17054	60S acidic ribosomal protein P0; Ribosomal protein P0 is the functional equivalent of E.coli protein L10. (326 aa)
	GL50803_91476	Uncharacterized protein. (1068 aa)
	GL50803_16328	DRAP deaminase. (568 aa)
	GL50803_13412	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes. (251 aa)
	GL50803_14641	Transducin. (545 aa)
	GL50803_96537	ATP-dependent RNA helicase. (616 aa)
	GL50803_7870	Ribosomal protein L23A; Belongs to the universal ribosomal protein uL23 family. (141 aa)
	GL50803_16371	Nucleolar GTP-binding protein 1; Involved in the biogenesis of the 60S ribosomal subunit. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily. (676 aa)
	GL50803_11287	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family. (122 aa)
	GL50803_10428	Ribosomal protein L10. (210 aa)
	GL50803_12598	KRR1 small subunit processome component; Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. (328 aa)
	GL50803_15487	WD-40 repeat protein. (960 aa)

Your Current Organism:

Giardia lamblia ATCC 50803

NCBI taxonomy Id: 184922
Other names: G. lamblia ATCC 50803, Giardia intestinalis ATCC 50803

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
EIF6	GL50803_103887	A8B8Z3	A8BQJ3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Endoribonuclease Dicer-like; Involved in cleaving double-stranded RNA in the RNA interference (RNAi) pathway. It produces 21 to 23 bp dsRNAs (siRNAs) which target the selective destruction of homologous RNAs.	0.643
EIF6	GL50803_10428	A8B8Z3	A8BM86	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L10.	0.999
EIF6	GL50803_10810	A8B8Z3	A8BB01	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.990
EIF6	GL50803_11287	A8B8Z3	A8BMJ0	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.834
EIF6	GL50803_113655	A8B8Z3	A8BTA3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.443
EIF6	GL50803_113971	A8B8Z3	A8B4P5	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Transducin.	0.999
EIF6	GL50803_11755	A8B8Z3	A8B8T6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Uncharacterized protein.	0.999
EIF6	GL50803_11984	A8B8Z3	A8BZ40	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosome biogenesis regulatory protein; Involved in ribosomal large subunit assembly. Belongs to the RRS1 family.	0.757
EIF6	GL50803_12055	A8B8Z3	A8BFK6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Elongation factor 2.	0.845
EIF6	GL50803_12981	A8B8Z3	A8BZD3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein S5.	0.641
EIF6	GL50803_13412	A8B8Z3	A8BN05	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosome assembly factor mrt4; Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.	0.999
EIF6	GL50803_13661	A8B8Z3	A8BRM0	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Eukaryotic translation initiation factor 3 subunit 2.	0.714
EIF6	GL50803_137690	A8B8Z3	A8BIQ2	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Helicase C-terminal domain-containing protein.	0.443
EIF6	GL50803_13791	A8B8Z3	A8BCX9	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	ATP-dependent RNA helicase.	0.443
EIF6	GL50803_13926	A8B8Z3	A8BCB6	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribonucloprotein; Common component of the spliceosome and rRNA processing machinery; Belongs to the eukaryotic ribosomal protein eL8 family.	0.812
EIF6	GL50803_14091	A8B8Z3	A8B4F8	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L14.	0.999
EIF6	GL50803_14098	A8B8Z3	A8BEM9	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family.	0.434
EIF6	GL50803_14869	A8B8Z3	A8B7P2	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L24.	0.999
EIF6	GL50803_15046	A8B8Z3	A8BFT3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein L26.	0.999
EIF6	GL50803_15260	A8B8Z3	A8BBP3	Eukaryotic translation initiation factor 6; Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.	Ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family.	0.517