(44 nodes) Methylation network (Giardia lamblia ATCC 50803)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GL50803_4538	Uncharacterized protein. (66 aa)
	GL50803_19867	Uncharacterized protein. (129 aa)
	GL50803_14327	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (304 aa)
	GL50803_21512	S-adenosylmethionine-dependent methyltransferase, putative. (291 aa)
	GL50803_17013	Protein-S-isoprenylcysteine O-methyltransferase. (215 aa)
	GL50803_13889	Maf-like protein yhdE. (193 aa)
	GL50803_100959	Uncharacterized protein. (323 aa)
	GL50803_12235	tRNA (guanine(26)-N(2))-dimethyltransferase. (532 aa)
	GL50803_12215	S-adenosylmethionine-dependent methyltransferase, putative. (264 aa)
	GL50803_10516	Leucine carboxyl methyltransferase 1; Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha- leucine ester residues; Belongs to the methyltransferase superfamily. LCMT family. (364 aa)
	GL50803_8191	TsaA-like domain-containing protein. (395 aa)
	GL50803_15280	SAM-dependent MTase TRM10-type domain-containing protein. (253 aa)
	GL50803_22338	mRNA cap guanine-N7 methyltransferase. (422 aa)
	GL50803_1903	DNA methyltransferase. (220 aa)
	GL50803_17199	Sun/nucleolar protein family protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (742 aa)
	GL50803_32741	TAR RNA loop binding protein, putative. (1127 aa)
	GL50803_4246	PRIP-interacting protein PIPMT. (300 aa)
	GL50803_5013	Endothelin-converting enzyme 2. (208 aa)
	GL50803_24111	Phosphorylated CTD interacting factor PCIF1. (599 aa)
	GL50803_13838	Uncharacterized protein. (380 aa)
	GL50803_28666	Diphthine synthase. (290 aa)
	GL50803_8921	Set-2, putative. (692 aa)
	GL50803_16993	FtsJ cell division protein, putative. (1084 aa)
	GL50803_3985	tRNA/rRNA cytosine-C5-methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (458 aa)
	GL50803_2323	Uncharacterized protein. (538 aa)
	GL50803_97219	Fibrillarin-like pre-rRNA processing protein Narcisi et al. (327 aa)
	GL50803_93103	TRMT2A-like protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (705 aa)
	GL50803_16948	Nucleolar protein NOP2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (502 aa)
	GL50803_13525	RNA methylase, putative. (496 aa)
	GL50803_4164	tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family. (447 aa)
	GL50803_6055	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (268 aa)
	GL50803_5786	Ribosome biogenesis protein NEP1, putative. (231 aa)
	GL50803_10335	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family. (258 aa)
	GL50803_4349	Endothelin-converting enzyme 2. (213 aa)
	GL50803_103058	Methyltransferase, putative. (416 aa)
	GL50803_9130	Histone methyltransferase HMT1. (298 aa)
	GL50803_5820	Uncharacterized protein. (496 aa)
	GL50803_3948	Methyltransf_11 domain-containing protein. (189 aa)
	GL50803_13196	Uncharacterized protein. (699 aa)
	GL50803_100887	Methyltransferase, putative. (416 aa)
	GL50803_14842	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. (316 aa)
	GL50803_7416	Methyltransferase, putative. (275 aa)
	GL50803_8691	tRNA (adenine(58)-N(1))-methyltransferase. (350 aa)
	GL50803_5613	Uncharacterized protein. (258 aa)

Your Current Organism:

Giardia lamblia ATCC 50803

NCBI taxonomy Id: 184922
Other names: G. lamblia ATCC 50803, Giardia intestinalis ATCC 50803

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GL50803_100959	GL50803_13889	A8BQA4	A8BRB1	Uncharacterized protein.	Maf-like protein yhdE.	0.512
GL50803_100959	GL50803_5786	A8BQA4	A8B2J7	Uncharacterized protein.	Ribosome biogenesis protein NEP1, putative.	0.405
GL50803_10335	GL50803_12235	A8B2F8	A8BPX4	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	tRNA (guanine(26)-N(2))-dimethyltransferase.	0.854
GL50803_10335	GL50803_13525	A8B2F8	A8B5G5	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	RNA methylase, putative.	0.785
GL50803_10335	GL50803_14327	A8B2F8	A8BT31	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family.	0.410
GL50803_10335	GL50803_14842	A8B2F8	A8BXW1	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	rRNA adenine N(6)-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.	0.893
GL50803_10335	GL50803_15280	A8B2F8	A8BJI6	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	SAM-dependent MTase TRM10-type domain-containing protein.	0.843
GL50803_10335	GL50803_16948	A8B2F8	A8B636	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	Nucleolar protein NOP2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.726
GL50803_10335	GL50803_16993	A8B2F8	A8BBN3	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	FtsJ cell division protein, putative.	0.874
GL50803_10335	GL50803_17199	A8B2F8	A8BIF9	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	Sun/nucleolar protein family protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.805
GL50803_10335	GL50803_1903	A8B2F8	A8BJ23	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	DNA methyltransferase.	0.407
GL50803_10335	GL50803_19867	A8B2F8	A8BTN3	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	Uncharacterized protein.	0.748
GL50803_10335	GL50803_21512	A8B2F8	A8BSU4	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	S-adenosylmethionine-dependent methyltransferase, putative.	0.736
GL50803_10335	GL50803_2323	A8B2F8	A8B9U9	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	Uncharacterized protein.	0.947
GL50803_10335	GL50803_32741	A8B2F8	A8BHT7	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	TAR RNA loop binding protein, putative.	0.838
GL50803_10335	GL50803_3985	A8B2F8	A8BA69	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	tRNA/rRNA cytosine-C5-methylase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.577
GL50803_10335	GL50803_6055	A8B2F8	A8B3D0	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs.	0.873
GL50803_10335	GL50803_8691	A8B2F8	A8BWP1	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	tRNA (adenine(58)-N(1))-methyltransferase.	0.959
GL50803_10335	GL50803_93103	A8B2F8	A8B660	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	TRMT2A-like protein; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.	0.869
GL50803_10335	GL50803_97219	A8B2F8	A8B9Q3	tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.	Fibrillarin-like pre-rRNA processing protein Narcisi et al.	0.444